New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity

Socea, Laura Ileana; Barbuceanu, Stefania Felicia; Socea, Bogdan; Draghici, Constantin; Apostol, Theodora Venera; Pahontu, Elena Mihaela; Olaru, Octavian Tudorel

Laura Ileana Socea, Stefania Felicia Barbuceanu, Bogdan Socea, Constantin Draghici, Theodora Venera Apostol, Elena Mihaela Pahontu, Octavian Tudorel Olaru

New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity

Abstract:

Acylhydrazinecarbothioamides (2a,b) were synthesized by addition of 2-(5H-dibenzo[a,d][7]annulen-5-yl)acetohydrazide to different isothiocyanates. The new 1,2,4-triazol-3-thioles (3a,b) were synthesized by cyclization of new 2- acylhydrazinecarbothioamides (3a,b) in basic media. Alkylation of 1,2,4-triazole-3-thiols (3a-c) with ethyl bromide gave only S-substituted derivatives (4a-c). The structures of the synthesized compounds have been established on spectral data (IR, 1H-NMR and 13C-NMR spectroscopy) and elemental analysis. The cytotoxic effect of new compounds was evaluated using two alternative models on plant and invertebrate organisms.

Keywords:
acylhydrazinecarbothioamide; 1;2;4-triazol-3-thiole; dibenzo<7>annulene; alkylation; cytotoxicity

Issue: 2017, Volume 68, Issue 11

Pages: 2503-2508

Publication date: 2017/12/15

https://doi.org/10.37358/RC.17.11.5916

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SOCEA, L.I., BARBUCEANU, S.F., SOCEA, B., DRAGHICI, C., APOSTOL, T.V., PAHONTU, E.M., OLARU, O.T., New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity, Rev. Chim., 68(11), 2017, 2503-2508.

Vancouver
Socea LI, Barbuceanu SF, Socea B, Draghici C, Apostol TV, Pahontu EM, Olaru OT. New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity. Rev. Chim.[internet]. 2017 Nov;68(11):2503-2508. Available from: https://doi.org/10.37358/RC.17.11.5916

APA 6th edition
Socea, L.I., Barbuceanu, S.F., Socea, B., Draghici, C., Apostol, T.V., Pahontu, E.M. & Olaru, O.T. (2017). New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity. Revista de Chimie, 68(11), 2503-2508. https://doi.org/10.37358/RC.17.11.5916

Harvard
Socea, L.I., Barbuceanu, S.F., Socea, B., Draghici, C., Apostol, T.V., Pahontu, E.M., Olaru, O.T. (2017). 'New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity', Revista de Chimie, 68(11), pp. 2503-2508. https://doi.org/10.37358/RC.17.11.5916

IEEE
L.I. Socea, S.F. Barbuceanu, B. Socea, C. Draghici, T.V. Apostol, E.M. Pahontu, O.T. Olaru, "New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity". Revista de Chimie, vol. 68, no. 11, pp. 2503-2508, 2017. [online]. https://doi.org/10.37358/RC.17.11.5916

Text
Laura Ileana Socea, Stefania Felicia Barbuceanu, Bogdan Socea, Constantin Draghici, Theodora Venera Apostol, Elena Mihaela Pahontu, Octavian Tudorel Olaru,
New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity,
Revista de Chimie,
Volume 68, Issue 11,
2017,
Pages 2503-2508,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.11.5916.
(https://revistadechimie.ro/Articles.asp?ID=5916)
Keywords: acylhydrazinecarbothioamide; 1;2;4-triazol-3-thiole; dibenzo<7>annulene; alkylation; cytotoxicity

RIS
TY - JOUR
T1 - New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity
A1 - Socea, Laura Ileana
A2 - Barbuceanu, Stefania Felicia
A3 - Socea, Bogdan
A4 - Draghici, Constantin
A5 - Apostol, Theodora Venera
A6 - Pahontu, Elena Mihaela
A7 - Olaru, Octavian Tudorel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 11
SP - 2503
EP - 2508
UR - https://doi.org/10.37358/RC.17.11.5916
KW - acylhydrazinecarbothioamide; 1
KW - 2
KW - 4-triazol-3-thiole; dibenzoKW - d><7>annulene; alkylation; cytotoxicity
ER -

BibTex
@article{RevCh2017P2503,
author = {Socea Laura Ileana and Barbuceanu Stefania Felicia and Socea Bogdan and Draghici Constantin and Apostol Theodora Venera and Pahontu Elena Mihaela and Olaru Octavian Tudorel},
title = {New Heterocyclic Compounds from 1,2,4-triazoles Class with Potential Cytotoxic Activity},
journal = {Revista de Chimie},
volume = {68},
number = {11},
pages = {2503-2508},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.11.5916},
url = {https://revistadechimie.ro/Articles.asp?ID=5916}
}

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