Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy

Jugulete, Gheorghita; Iacob, Simona; Merisescu, Madalina; Luminos, Monica

Gheorghita Jugulete, Simona Iacob, Madalina Merisescu, Monica Luminos

Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy

Abstract:

In this paper we propose to present the biochemical modifications in children and adolescents with HIV infection/AIDS undergoing antiretroviral therapy (ART). We have carried out a retrospective study on 200 HIV-seropositive children registered in our department, without any prior workup modifications, in which antiretroviral therapy was initiated. In all patients we have monitored serum glucose, amylasemia, natremia, and liver enzymes. Most of the biochemical modifications were mild and moderate and did not necessitate cessation of therapy. In only 2 cases, modifications were severe enough to impose a temporary interruption of the ART: one case with elevated triglycerides and one case with elevated liver enzymes. After 24 months of ART, approximately 11.5% (23/200) of the monitored patients had biochemical modifications: 3.5 % elevated triglycerides, 5% elevated liver enzymes, 2.5 % hyperamylasemia, and 0.5 % hypernatremia. Biochemical modifications were more significant in patients who received prior antiretroviral therapy, particularly those who received protease inhibitors (PIs) in comparison to patients naive to ART.

Keywords:
biochemical modifications; HIV; child

Issue: 2017, Volume 68, Issue 11

Pages: 2578-2581

Publication date: 2017/12/15

https://doi.org/10.37358/RC.17.11.5932

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
JUGULETE, G., IACOB, S., MERISESCU, M., LUMINOS, M., Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy, Rev. Chim., 68(11), 2017, 2578-2581.

Vancouver
Jugulete G, Iacob S, Merisescu M, Luminos M. Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy. Rev. Chim.[internet]. 2017 Nov;68(11):2578-2581. Available from: https://doi.org/10.37358/RC.17.11.5932

APA 6th edition
Jugulete, G., Iacob, S., Merisescu, M. & Luminos, M. (2017). Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy. Revista de Chimie, 68(11), 2578-2581. https://doi.org/10.37358/RC.17.11.5932

Harvard
Jugulete, G., Iacob, S., Merisescu, M., Luminos, M. (2017). 'Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy', Revista de Chimie, 68(11), pp. 2578-2581. https://doi.org/10.37358/RC.17.11.5932

IEEE
G. Jugulete, S. Iacob, M. Merisescu, M. Luminos, "Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy". Revista de Chimie, vol. 68, no. 11, pp. 2578-2581, 2017. [online]. https://doi.org/10.37358/RC.17.11.5932

Text
Gheorghita Jugulete, Simona Iacob, Madalina Merisescu, Monica Luminos,
Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy,
Revista de Chimie,
Volume 68, Issue 11,
2017,
Pages 2578-2581,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.11.5932.
(https://revistadechimie.ro/Articles.asp?ID=5932)
Keywords: biochemical modifications; HIV; child

RIS
TY - JOUR
T1 - Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy
A1 - Jugulete, Gheorghita
A2 - Iacob, Simona
A3 - Merisescu, Madalina
A4 - Luminos, Monica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 11
SP - 2578
EP - 2581
UR - https://doi.org/10.37358/RC.17.11.5932
KW - biochemical modifications
KW - HIV
KW - child
ER -

BibTex
@article{RevCh2017P2578,
author = {Jugulete Gheorghita and Iacob Simona and Merisescu Madalina and Luminos Monica},
title = {Biochemical Modifications in HIV-Infected Children and Adolescents Under Antiretroviral Therapy},
journal = {Revista de Chimie},
volume = {68},
number = {11},
pages = {2578-2581},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.11.5932},
url = {https://revistadechimie.ro/Articles.asp?ID=5932}
}

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