The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children

Puiac, Mariana Anisoara(Ciorba); Suciu, Horatiu; Ciorba, Marius Ilie; Opris, Mihaela Maria; Hussein, Hussam Al; Hussein, Hamida Al; Brinzaniuc, Klara

Mariana Anisoara (Ciorba) Puiac, Horatiu Suciu, Marius Ilie Ciorba, Mihaela Maria Opris, Hussam Al Hussein, Hamida Al Hussein, Klara Brinzaniuc

The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children

Abstract:

The purpose of the study was to prove to efficacy of Milrinone in the management of open heart surgery in children with congenital heart malformations, the link between Milrinone efficacy and the prevention of low cardiac output syndrome and Milrinone side effects. We conducted a retrospective study on a group of 24 patients, admitted to the Tg Mures Emergency Institute for Cardiovascular Diseases and Transplant, between August 2016 and February 2017. Milrinone was administered to children that underwent open heart surgery for different congenital heart malformations, using doses between 0.25 and 0.75 mcg per kg bodyweight, in continuous intravenous drip, before de-clamping of the Aorta, the procedures being conducted in extracorporeal circulation. We recorded demographic data, biological parameters of renal function, myocardial function and hemodynamic parameters, before and after surgery. The administration of Milrinone determined a reduction of incidence of low cardiac output syndrome, registering only 4 deaths, the survival rate being 83.33%, 13 cases presenting complications. Postoperatively we registered a significant improvement of the mean heart rate. Milrinone proved efficient in the re-establishment of hemodynamic parameters in patients with this type of clinical manifestations. Using Milrinone in children that undergo open heart surgery determines a decrease in incidence of low cardiac output syndrome, its’ presence in the pharma market being necessary.

Keywords:
phosphodiesterase inhibitors; positive inotropes; milrinone; low cardiac output syndrome; pediatric cardiac surgery

Issue: 2017, Volume 68, Issue 11

Pages: 2658-2661

Publication date: 2017/12/15

https://doi.org/10.37358/RC.17.11.5949

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PUIAC, M.A., SUCIU, H., CIORBA, M.I., OPRIS, M.M., HUSSEIN, H.A., HUSSEIN, H.A., BRINZANIUC, K., The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children, Rev. Chim., 68(11), 2017, 2658-2661.

Vancouver
Puiac MA, Suciu H, Ciorba MI, Opris MM, Hussein HA, Hussein HA, Brinzaniuc K. The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children. Rev. Chim.[internet]. 2017 Nov;68(11):2658-2661. Available from: https://doi.org/10.37358/RC.17.11.5949

APA 6th edition
Puiac, M.A., Suciu, H., Ciorba, M.I., Opris, M.M., Hussein, H.A., Hussein, H.A. & Brinzaniuc, K. (2017). The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children. Revista de Chimie, 68(11), 2658-2661. https://doi.org/10.37358/RC.17.11.5949

Harvard
Puiac, M.A., Suciu, H., Ciorba, M.I., Opris, M.M., Hussein, H.A., Hussein, H.A., Brinzaniuc, K. (2017). 'The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children', Revista de Chimie, 68(11), pp. 2658-2661. https://doi.org/10.37358/RC.17.11.5949

IEEE
M.A. Puiac, H. Suciu, M.I. Ciorba, M.M. Opris, H.A. Hussein, H.A. Hussein, K. Brinzaniuc, "The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children". Revista de Chimie, vol. 68, no. 11, pp. 2658-2661, 2017. [online]. https://doi.org/10.37358/RC.17.11.5949

Text
Mariana Anisoara(Ciorba) Puiac, Horatiu Suciu, Marius Ilie Ciorba, Mihaela Maria Opris, Hussam Al Hussein, Hamida Al Hussein, Klara Brinzaniuc,
The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children,
Revista de Chimie,
Volume 68, Issue 11,
2017,
Pages 2658-2661,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.11.5949.
(https://revistadechimie.ro/Articles.asp?ID=5949)
Keywords: phosphodiesterase inhibitors; positive inotropes; milrinone; low cardiac output syndrome; pediatric cardiac surgery

RIS
TY - JOUR
T1 - The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children
A1 - Puiac, Mariana Anisoara(Ciorba)
A2 - Suciu, Horatiu
A3 - Ciorba, Marius Ilie
A4 - Opris, Mihaela Maria
A5 - Hussein, Hussam Al
A6 - Hussein, Hamida Al
A7 - Brinzaniuc, Klara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 11
SP - 2658
EP - 2661
UR - https://doi.org/10.37358/RC.17.11.5949
KW - phosphodiesterase inhibitors
KW - positive inotropes
KW - milrinone
KW - low cardiac output syndrome
KW - pediatric cardiac surgery
ER -

BibTex
@article{RevCh2017P2658,
author = {Puiac Mariana Anisoara(Ciorba) and Suciu Horatiu and Ciorba Marius Ilie and Opris Mihaela Maria and Hussein Hussam Al and Hussein Hamida Al and Brinzaniuc Klara},
title = {The implications of Milrinone Lactate in the Postoperative Clinical Management of Surgical Interventions for Congenital Heart Malformations in Children},
journal = {Revista de Chimie},
volume = {68},
number = {11},
pages = {2658-2661},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.11.5949},
url = {https://revistadechimie.ro/Articles.asp?ID=5949}
}

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