Andreea Dana Neacsu, Elena Pincu, Gabriel Munteanu, Cornel Munteanu, Viorica Meltzer
Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil
Abstract:
The objective of the present work was to obtain and evaluate the solid inclusion complexes of a-, b-cyclodextrins and hydroxypropyl-a-, hydroxypropyl-b-cyclodextrins derivatives with uracil (U) and anti-cancer agent 5-fluorouracil (5FU). The thermogravimetry (TG), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy in attenuated total reflectance mode (FTIR-ATR) and scanning electron microscopy (SEM) were used to characterize these inclusion compounds. New information on the physicochemical behavior of these solid state complexes synthesized by melting in solution was obtained. Corelating the experimental data we found that the complexation occurs for each host:guest system thus, the preparation method exhibited a real efficiency to interaction achievements. The inclusion capability and the thermal stability of the studied complexes were due to both the flexibility and the size of the cyclodextrin ring as well the stereoelectronic effect of the U or 5FU molecule. We appreciated that the complexes between U or 5FU with 2-hydroxypropyl derivatives of a- and b- CD have the largest content of guest and are the most stable. The obtained results could be useful in formulation of the pharmaceutical products and also in drug delivery.
Cite this article as: NEACSU, A.D., PINCU, E., MUNTEANU, G., MUNTEANU, C., MELTZER, V., Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil, Rev. Chim., 68(12), 2017, 2756-2760.
Vancouver Neacsu AD, Pincu E, Munteanu G, Munteanu C, Meltzer V. Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil. Rev. Chim.[internet]. 2017 Dec;68(12):2756-2760. Available from: https://doi.org/10.37358/RC.17.12.5971
APA 6th edition Neacsu, A.D., Pincu, E., Munteanu, G., Munteanu, C. & Meltzer, V. (2017). Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil. Revista de Chimie, 68(12), 2756-2760. https://doi.org/10.37358/RC.17.12.5971
Harvard Neacsu, A.D., Pincu, E., Munteanu, G., Munteanu, C., Meltzer, V. (2017). 'Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil', Revista de Chimie, 68(12), pp. 2756-2760. https://doi.org/10.37358/RC.17.12.5971
IEEE A.D. Neacsu, E. Pincu, G. Munteanu, C. Munteanu, V. Meltzer, "Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil". Revista de Chimie, vol. 68, no. 12, pp. 2756-2760, 2017. [online]. https://doi.org/10.37358/RC.17.12.5971
Text Andreea Dana Neacsu, Elena Pincu, Gabriel Munteanu, Cornel Munteanu, Viorica Meltzer, Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil, Revista de Chimie, Volume 68, Issue 12, 2017, Pages 2756-2760, ISSN 2668-8212, https://doi.org/10.37358/RC.17.12.5971. (https://revistadechimie.ro/Articles.asp?ID=5971) Keywords: Cyclodextrin; Uracil; 5-Fluorouracil; Inclusion Complexes; Thermal Behavior
RIS TY - JOUR T1 - Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil A1 - Neacsu, Andreea Dana A2 - Pincu, Elena A3 - Munteanu, Gabriel A4 - Munteanu, Cornel A5 - Meltzer, Viorica JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2017 VL - 68 IS - 12 SP - 2756 EP - 2760 UR - https://doi.org/10.37358/RC.17.12.5971 KW - Cyclodextrin KW - Uracil KW - 5-Fluorouracil KW - Inclusion Complexes KW - Thermal Behavior ER -
BibTex @article{RevCh2017P2756, author = {Neacsu Andreea Dana and Pincu Elena and Munteanu Gabriel and Munteanu Cornel and Meltzer Viorica}, title = {Characterization and Comparison of the Solid State Inclusion Compounds of alfa-, beta-Cyclodextrins and its 2-Hydroxypropyl Derivatives with Uracil and 5-fluorouracil}, journal = {Revista de Chimie}, volume = {68}, number = {12}, pages = {2756-2760}, year = {2017}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.17.12.5971}, url = {https://revistadechimie.ro/Articles.asp?ID=5971} }
