The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure

Puiac, Claudiu; Jung, Ioan; Puscasiu, Lucian; Szederjesi, Janos

Claudiu Puiac, Ioan Jung, Lucian Puscasiu, Janos Szederjesi

The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure

Abstract:

The aim of this study was to evaluate the correlation between serum and tissue level of the Neutrophil gelatinase-associated lipocalin (NGAL), a peptide that seems to be predict the postoperative evolution of patients with high abdominal pressure. From 30 consecutive patients hospitalized in the Intensive Care Unit, we have randomly selected five cases that undergo abdominal surgical interventions, received postoperative mechanical ventilation and abdominal pressure was monitorized for at least 48 hours. In all of these cases, the plasmatic level of NGAL was measured using the Elisa method and immunohistochemical (IHC) stains with the anti-NGAL biomarker were performed in the surgically removed tissues. All of the five patients were overweight, showed high serum level of NGAL (over 950 ng/ml) and died with postoperative or septic shock. The NGAL serum level was not correlated with the abdominal pressure. No IHC positivity was observed in the examined tissues, except NGAL positivity for intravascular neutrophils. In conclusion, the postoperative high serum NGAL level may indicate unfavorable evolution. NGAL seems to be syntesized by the circulating neutrophils and its preoperative tissue expression does not reflect the serum value.

Keywords:
NGAL; peptide; lipocalin; ELISA

Issue: 2017, Volume 68, Issue 12

Pages: 2850-2852

Publication date: 2018/1/15

https://doi.org/10.37358/RC.17.12.5992

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PUIAC, C., JUNG, I., PUSCASIU, L., SZEDERJESI, J., The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure, Rev. Chim., 68(12), 2017, 2850-2852.

Vancouver
Puiac C, Jung I, Puscasiu L, Szederjesi J. The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure. Rev. Chim.[internet]. 2017 Dec;68(12):2850-2852. Available from: https://doi.org/10.37358/RC.17.12.5992

APA 6th edition
Puiac, C., Jung, I., Puscasiu, L. & Szederjesi, J. (2017). The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure. Revista de Chimie, 68(12), 2850-2852. https://doi.org/10.37358/RC.17.12.5992

Harvard
Puiac, C., Jung, I., Puscasiu, L., Szederjesi, J. (2017). 'The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure', Revista de Chimie, 68(12), pp. 2850-2852. https://doi.org/10.37358/RC.17.12.5992

IEEE
C. Puiac, I. Jung, L. Puscasiu, J. Szederjesi, "The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure". Revista de Chimie, vol. 68, no. 12, pp. 2850-2852, 2017. [online]. https://doi.org/10.37358/RC.17.12.5992

Text
Claudiu Puiac, Ioan Jung, Lucian Puscasiu, Janos Szederjesi,
The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 2850-2852,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.5992.
(https://revistadechimie.ro/Articles.asp?ID=5992)
Keywords: NGAL; peptide; lipocalin; ELISA

RIS
TY - JOUR
T1 - The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure
A1 - Puiac, Claudiu
A2 - Jung, Ioan
A3 - Puscasiu, Lucian
A4 - Szederjesi, Janos
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 2850
EP - 2852
UR - https://doi.org/10.37358/RC.17.12.5992
KW - NGAL
KW - peptide
KW - lipocalin
KW - ELISA
ER -

BibTex
@article{RevCh2017P2850,
author = {Puiac Claudiu and Jung Ioan and Puscasiu Lucian and Szederjesi Janos},
title = {The Postoperative Plasmatic Level of Neutrophil Gelatinase-associated Lipocalin Does not Reflect its Tissue Expression in Critically ill Patients with High Abdominal Pressure},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {2850-2852},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.5992},
url = {https://revistadechimie.ro/Articles.asp?ID=5992}
}

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