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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 1, 140-143

https://doi.org/10.37358/RC.18.1.6060

Gabi Dumitrescu, Ioan Pet, Dorel Dronca, Mirela Ahmadi, Liliana Petculescu Ciochina, Nicoleta Marioara Filimon, Roxana Popescu

New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice

Abstract:

The reproductive system of the vertebrates - mainly of the adult males -seems to be vulnerable to the action of endocrine disruptors. The aim of this study was to evaluate the effect of octylphenol (OP) on histological structure of testis in NMRI mice. The mice were divided in three groups (5 mice for each group) such as: control group (C - untreated); vehicle group (V - treated with a mixture of ethanol and corn oil 1:10) and experimental group (E - treated with OP in concentration of 160 mg/kg body weight). The solution of OP was prepared in ethanol, administered by subcutaneous injection in the thigh region (1 ml total volume), for seven consecutive days. For histological examination, after slaughtering, the testes were fixed in 10% neutral formalin, embedded in paraffin, sectioned to a thickness of 5 µm and stained with Mallory’s trichrome method. Microscopic analysis reveals in the individuals from the C and V groups, the normal morphology of the seminiferous tubules. In the case of individuals in the E group, treated with OP, in the testicular parenchyma occurs changes consisting in: detachment of the seminiferous tubule epithelium, mild proliferation of germ cells, the presence of apoptotic bodies among the cells of seminal line, diffuse hyperplasia of the Leydig interstitial cells and hypertrophy of the peritubular capillary. Experimental data obtained in this study demonstrated that the treatment with octylphenol induces irreversible changes in the testicular parenchyma with the disruption of spermatogenesis process.
Keywords:
octylphenol; testis; mice; histology

Issue: 2018, Volume 69, Issue 1
Pages: 140-143
Publication date: 15/02/2018
https://doi.org/10.37358/RC.18.1.6060
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
DUMITRESCU, G., PET, I., DRONCA, D., AHMADI, M., CIOCHINA, L.P., FILIMON, N.M., POPESCU, R., New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice, Rev. Chim., 69(1), 2018, 140-143.

Vancouver
Dumitrescu G, Pet I, Dronca D, Ahmadi M, Ciochina LP, Filimon NM, Popescu R. New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice. Rev. Chim.[internet]. 2018 Jan;69(1):140-143. Available from: https://doi.org/10.37358/RC.18.1.6060


APA 6th edition
Dumitrescu, G., Pet, I., Dronca, D., Ahmadi, M., Ciochina, L.P., Filimon, N.M. & Popescu, R. (2018). New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice. Revista de Chimie, 69(1), 140-143. https://doi.org/10.37358/RC.18.1.6060


Harvard
Dumitrescu, G., Pet, I., Dronca, D., Ahmadi, M., Ciochina, L.P., Filimon, N.M., Popescu, R. (2018). 'New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice', Revista de Chimie, 69(1), pp. 140-143. https://doi.org/10.37358/RC.18.1.6060


IEEE
G. Dumitrescu, I. Pet, D. Dronca, M. Ahmadi, L.P. Ciochina, N.M. Filimon, R. Popescu, "New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice". Revista de Chimie, vol. 69, no. 1, pp. 140-143, 2018. [online]. https://doi.org/10.37358/RC.18.1.6060


Text
Gabi Dumitrescu, Ioan Pet, Dorel Dronca, Mirela Ahmadi, Liliana Petculescu Ciochina, Nicoleta Marioara Filimon, Roxana Popescu,
New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice,
Revista de Chimie,
Volume 69, Issue 1,
2018,
Pages 140-143,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.1.6060.
(https://revistadechimie.ro/Articles.asp?ID=6060)
Keywords: octylphenol; testis; mice; histology


RIS
TY - JOUR
T1 - New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice
A1 - Dumitrescu, Gabi
A2 - Pet, Ioan
A3 - Dronca, Dorel
A4 - Ahmadi, Mirela
A5 - Ciochina, Liliana Petculescu
A6 - Filimon, Nicoleta Marioara
A7 - Popescu, Roxana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 1
SP - 140
EP - 143
UR - https://doi.org/10.37358/RC.18.1.6060
KW - octylphenol
KW - testis
KW - mice
KW - histology
ER -


BibTex
@article{RevCh2018P140,
author = {Dumitrescu Gabi and Pet Ioan and Dronca Dorel and Ahmadi Mirela and Ciochina Liliana Petculescu and Filimon Nicoleta Marioara and Popescu Roxana},
title = {New Research about the Effect of Octylphenol (4-tOP) on Histological Structure of Testis in Mice},
journal = {Revista de Chimie},
volume = {69},
number = {1},
pages = {140-143},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.1.6060},
url = {https://revistadechimie.ro/Articles.asp?ID=6060}
}
 
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