Mihaela Pertea, Vladimir Poroch, Oxana Madalina Grosu, Sorinel Lunca
Study on Epinephrine Used in Local Anesthesia Controversy and certainty
Abstract:
Epinephrine (adrenaline) - C9H13NO3 - was synthesized for the first time by Fredrich Stelz in 1904 from phenylalanine. After a hydrolysis and decarboxylation process, active dopamine is obtained. Following the pathway of other hydroxylation followed by N-methylation, epinephrine synthesis is achieved. Epinephrine has initially been administrated together with procaine in local anesthesia in hand surgery. Epinephrine has been considered to be one of causes of ischemia and necrosis in hand and especially fingers surgery. Over time, studies have shown the efficacy and safety of using lidocaine-associated epinephrine in local hand surgery anesthesia. Numerous advantages regarding the use of lidocaine 1% with epinephrine, solution at a concentration of 1:100,000 have been reported, starting with increasing the duration of anesthesia, avoiding the use of tourniquet, leading to increased patient comfort and to the advantage of a much lower cost in terms of surgery as a whole. Our study group consisted of fifty patients with hand and fingers different patologies. In all cases surgery was performed under local anesthesia using lidocaine 1% with epinephrine, solution at a concentration of 1:100,000. The decrease of doses mentioned in the literature was attempted and in some cases the decrease was up to 30%. There have not been reported any ischemic or necrosis complication in the immediate postoperative period.
Keywords: lidocaine; epinephrine; local anesthesia; hand surgery
Cite this article as: PERTEA, M., POROCH, V., GROSU, O.M., LUNCA, S., Study on Epinephrine Used in Local Anesthesia Controversy and certainty, Rev. Chim., 69(1), 2018, 169-171.
Vancouver Pertea M, Poroch V, Grosu OM, Lunca S. Study on Epinephrine Used in Local Anesthesia Controversy and certainty. Rev. Chim.[internet]. 2018 Jan;69(1):169-171. Available from: https://doi.org/10.37358/RC.18.1.6067
APA 6th edition Pertea, M., Poroch, V., Grosu, O.M. & Lunca, S. (2018). Study on Epinephrine Used in Local Anesthesia Controversy and certainty. Revista de Chimie, 69(1), 169-171. https://doi.org/10.37358/RC.18.1.6067
Harvard Pertea, M., Poroch, V., Grosu, O.M., Lunca, S. (2018). 'Study on Epinephrine Used in Local Anesthesia Controversy and certainty', Revista de Chimie, 69(1), pp. 169-171. https://doi.org/10.37358/RC.18.1.6067
IEEE M. Pertea, V. Poroch, O.M. Grosu, S. Lunca, "Study on Epinephrine Used in Local Anesthesia Controversy and certainty". Revista de Chimie, vol. 69, no. 1, pp. 169-171, 2018. [online]. https://doi.org/10.37358/RC.18.1.6067
Text Mihaela Pertea, Vladimir Poroch, Oxana Madalina Grosu, Sorinel Lunca, Study on Epinephrine Used in Local Anesthesia Controversy and certainty, Revista de Chimie, Volume 69, Issue 1, 2018, Pages 169-171, ISSN 2668-8212, https://doi.org/10.37358/RC.18.1.6067. (https://revistadechimie.ro/Articles.asp?ID=6067) Keywords: lidocaine; epinephrine; local anesthesia; hand surgery
RIS TY - JOUR T1 - Study on Epinephrine Used in Local Anesthesia Controversy and certainty A1 - Pertea, Mihaela A2 - Poroch, Vladimir A3 - Grosu, Oxana Madalina A4 - Lunca, Sorinel JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2018 VL - 69 IS - 1 SP - 169 EP - 171 UR - https://doi.org/10.37358/RC.18.1.6067 KW - lidocaine KW - epinephrine KW - local anesthesia KW - hand surgery ER -
BibTex @article{RevCh2018P169, author = {Pertea Mihaela and Poroch Vladimir and Grosu Oxana Madalina and Lunca Sorinel}, title = {Study on Epinephrine Used in Local Anesthesia Controversy and certainty}, journal = {Revista de Chimie}, volume = {69}, number = {1}, pages = {169-171}, year = {2018}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.18.1.6067}, url = {https://revistadechimie.ro/Articles.asp?ID=6067} }
