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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 1, 232-235

https://doi.org/10.37358/RC.18.1.6079

Ciprian Ioan Roi, Pusa Nela Gaje, Raluca Amalia Ceausu, Ramona Amina Popovici, Marius Raica

Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease

Abstract:

Langerhans cells are antigen presenting cells, located in the stratified squamous epithelium of the skin and oral epithelium. A high density of Langerhans cells in gingival epithelium associated with an inflammatory process has been demonstrated in the literature by numerous studies, although the relationship with inflammation was less investigated.The aim of our study was to evaluate the distribution, density, morphology of Langerhans cells in both gingival epithelium and the associated inflammatory infiltrate in the lamina propria of the gingiva. The relationship between Langerhans cells and inflamatory process was also assesed. The present study included a number of 51 gingival biopsies. 12 of these didn’ t show significant changes on routine examination. In all of the other 39 cases the presence of inflammatory lesions was noticed. The inflamatory infiltrate was described by using hematoxylin eosin staining and quantitative score, with values between 0 and 3. Langerhans cells were immunohistochemicaly highlighted by using S100 antibody and quantified with hot spot method.We found an increase of Langerhans cells density in all cases of inflammation as compared with healthy gingival tissue. The highest density was found in the 13 cases with severe inflammation. At these last cases was noticed a migration tendency of Langerhans cells from infiltrate inflamatory area to basal layer of the epithelium. The results of this study indicated that Langerhans cells number is higher in inflamatory gingival tissue comparative with normal tissue, and the density of these cells is in relation with the severity of the inflammatory process.
Keywords:
Langerhans cells; antigen presenting cells; S100 protein; human gingival epithelium

Issue: 2018, Volume 69, Issue 1
Pages: 232-235
Publication date: 15/02/2018
https://doi.org/10.37358/RC.18.1.6079
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ROI, C.I., GAJE, P.N., CEAUSU, R.A., POPOVICI, R.A., RAICA, M., Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease, Rev. Chim., 69(1), 2018, 232-235.

Vancouver
Roi CI, Gaje PN, Ceausu RA, Popovici RA, Raica M. Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease. Rev. Chim.[internet]. 2018 Jan;69(1):232-235. Available from: https://doi.org/10.37358/RC.18.1.6079


APA 6th edition
Roi, C.I., Gaje, P.N., Ceausu, R.A., Popovici, R.A. & Raica, M. (2018). Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease. Revista de Chimie, 69(1), 232-235. https://doi.org/10.37358/RC.18.1.6079


Harvard
Roi, C.I., Gaje, P.N., Ceausu, R.A., Popovici, R.A., Raica, M. (2018). 'Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease', Revista de Chimie, 69(1), pp. 232-235. https://doi.org/10.37358/RC.18.1.6079


IEEE
C.I. Roi, P.N. Gaje, R.A. Ceausu, R.A. Popovici, M. Raica, "Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease". Revista de Chimie, vol. 69, no. 1, pp. 232-235, 2018. [online]. https://doi.org/10.37358/RC.18.1.6079


Text
Ciprian Ioan Roi, Pusa Nela Gaje, Raluca Amalia Ceausu, Ramona Amina Popovici, Marius Raica,
Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease,
Revista de Chimie,
Volume 69, Issue 1,
2018,
Pages 232-235,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.1.6079.
(https://revistadechimie.ro/Articles.asp?ID=6079)
Keywords: Langerhans cells; antigen presenting cells; S100 protein; human gingival epithelium


RIS
TY - JOUR
T1 - Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease
A1 - Roi, Ciprian Ioan
A2 - Gaje, Pusa Nela
A3 - Ceausu, Raluca Amalia
A4 - Popovici, Ramona Amina
A5 - Raica, Marius
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 1
SP - 232
EP - 235
UR - https://doi.org/10.37358/RC.18.1.6079
KW - Langerhans cells
KW - antigen presenting cells
KW - S100 protein
KW - human gingival epithelium
ER -


BibTex
@article{RevCh2018P232,
author = {Roi Ciprian Ioan and Gaje Pusa Nela and Ceausu Raluca Amalia and Popovici Ramona Amina and Raica Marius},
title = {Immunohistochemical Analysis of S100-Positive Langerhans Cells in the Healthy Gingiva and Periodontal Disease},
journal = {Revista de Chimie},
volume = {69},
number = {1},
pages = {232-235},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.1.6079},
url = {https://revistadechimie.ro/Articles.asp?ID=6079}
}
 
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