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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 1, 236-240

https://doi.org/10.37358/RC.18.1.6080

Simona Constantinescu, Claudia Elena Plesca, Paraschiva Postolache, Mihaela Catalina Luca

Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry

Abstract:

Methicillin-resistance phenomenon regarding Staphylococcus aureus which is often met as etiologic agent of severe systemic infections with oral-maxillofacial portal of entry imposes the first-line therapeutic schemes readjustment in patients with significant risk factors. Minimum inhibitory concentration (MIC) determination for every isolated S.aureus strain is useful for the antibiotherapy guiding, in order to choose the appropriate antimicrobial substances and to avoid the selection of resistant mutants. There have been studied and tested 9036 bacterial strains isolated from patients hospitalized in the Sf.Spiridon Emergency County Hospital between 2013-2016. Minimum inhibitory concentrations (MIC), MIC 50 and MIC 90 values were determined for the following antibiotics: Penycilline, Erithromycin, Oxacylline, Tetracycline, Gentamycin, Tobramycine, Kanamycin, Ryfampicyn, Trimethoprim-Sulfamethoxazole, Ofloxacine, Ciprofloxacine and Vancomycin.The classification of each identified bacterial strain into sensitive or resistant was accomplished according to the breakpoints recommended by CLSI 2016 (Clinical and Laboratory Standard Institute). We considered intermediately susceptible isolates as being resistant. S.aureus antibioresistance was high to tetracycline, erythromycin and kanamycin, with elevated MIC 90 values (64µg). The rate of resistance to penicillin in the case of S.aureus was 94.7%. The lowest MIC values regarding Pseudomonas aeruginosa were for imipenem, meropenem and colistin and the highest ones for piperacillin-tazobactam, ceftazidime and amikacin. Third generation cephalosporins demonstrated their inefficiency in the staphylococcal infections’ treatment as a consequence of an increasing resistance to this category of betalactams. Vancomycin remains a saving in-hospital therapeutic option in the case of MRSA implication, next to teicoplanin and linezolid.
Keywords:
antibioresistance; oro-dental sepsis; minimum inhibitory concentration

Issue: 2018, Volume 69, Issue 1
Pages: 236-240
Publication date: 2018/2/15
https://doi.org/10.37358/RC.18.1.6080
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CONSTANTINESCU, S., PLESCA, C.E., POSTOLACHE, P., LUCA, M.C., Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry, Rev. Chim., 69(1), 2018, 236-240.

Vancouver
Constantinescu S, Plesca CE, Postolache P, Luca MC. Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry. Rev. Chim.[internet]. 2018 Jan;69(1):236-240. Available from: https://doi.org/10.37358/RC.18.1.6080


APA 6th edition
Constantinescu, S., Plesca, C.E., Postolache, P. & Luca, M.C. (2018). Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry. Revista de Chimie, 69(1), 236-240. https://doi.org/10.37358/RC.18.1.6080


Harvard
Constantinescu, S., Plesca, C.E., Postolache, P., Luca, M.C. (2018). 'Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry', Revista de Chimie, 69(1), pp. 236-240. https://doi.org/10.37358/RC.18.1.6080


IEEE
S. Constantinescu, C.E. Plesca, P. Postolache, M.C. Luca, "Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry". Revista de Chimie, vol. 69, no. 1, pp. 236-240, 2018. [online]. https://doi.org/10.37358/RC.18.1.6080


Text
Simona Constantinescu, Claudia Elena Plesca, Paraschiva Postolache, Mihaela Catalina Luca,
Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry,
Revista de Chimie,
Volume 69, Issue 1,
2018,
Pages 236-240,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.1.6080.
(https://revistadechimie.ro/Articles.asp?ID=6080)
Keywords: antibioresistance; oro-dental sepsis; minimum inhibitory concentration


RIS
TY - JOUR
T1 - Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry
A1 - Constantinescu, Simona
A2 - Plesca, Claudia Elena
A3 - Postolache, Paraschiva
A4 - Luca, Mihaela Catalina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 1
SP - 236
EP - 240
UR - https://doi.org/10.37358/RC.18.1.6080
KW - antibioresistance
KW - oro-dental sepsis
KW - minimum inhibitory concentration
ER -


BibTex
@article{RevCh2018P236,
author = {Constantinescu Simona and Plesca Claudia Elena and Postolache Paraschiva and Luca Mihaela Catalina},
title = {Antibioresistance of Microbial Strains Implicated in the Etiology of Sepsis with Oro-Maxillofacial Portal of Entry},
journal = {Revista de Chimie},
volume = {69},
number = {1},
pages = {236-240},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.1.6080},
url = {https://revistadechimie.ro/Articles.asp?ID=6080}
}
 
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