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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 1, 241-247

https://doi.org/10.37358/RC.18.1.6081

Claudia Plesca, Carmen Manciuc, Egidia Miftode, Catalina Luca, Aida Badescu, Olivia Dorneanu, Luminita Smaranda Iancu

Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis

Abstract:

Nowadays opportunistic infections are not the only threat in the case of HIV-infected patients, being upstaged by microbial or fungal severe infections, especially after the introduction of ultimate generation antiretroviral therapy. The aim of this study is to investigate the factors that are predictive for an unfavourable prognosis and the causality of severe sepsis in HIV-immuno-depressed hosts. The study included 42 HIV-seropositive patients, found out in the evidence of HIV/AIDS Regional Centre from Iasi, that have been diagnosed with severe sepsis with confirmed etiology between the January 2012 and December 2016. The study group was subdivided in two subgroups: the first batch represented by twenty patients HIV-infected in childhood (pediatric cohort) and the second batch represented by 22 patients HIV-infected in adulthood. The medium age at the time of the sepsis diagnosis was significantly lower in the first group compared to the second one (25.0±2.58 vs 34.9±11.8). The lowest CD4 cells levels were noted in the case of patients infected in childhood, being in C2/C3 disease stage. The bacterial etiology was variate in both studied subgroups, with the predominance of Escherichia coli (33.3%), Staphylococcus aureus meticilino-rezistent (26.2%) and Streptococcus pneumoniae (19%) strains. The liver and kidney disfunctions were frecvently present in HIV-infected patients with severe sepsis (n=28 respectiv 31). A high percentage of patients associated criptocococcosis meningoencephalitis (33.3%), the most affected were those from the second subgroup (40.9%). Systemic infections in HIV-seropositive patients presumes an additional risk of unfavourable outcome, especially in the context of non-adherence and non-compliance to ARV-therapy and a long-term HIV infection history.
Keywords:
Severe sepsis; HIV Immunodepression; Antibiotherapy

Issue: 2018, Volume 69, Issue 1
Pages: 241-247
Publication date: 15/02/2018
https://doi.org/10.37358/RC.18.1.6081
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PLESCA, C., MANCIUC, C., MIFTODE, E., LUCA, C., BADESCU, A., DORNEANU, O., IANCU, L.S., Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis, Rev. Chim., 69(1), 2018, 241-247.

Vancouver
Plesca C, Manciuc C, Miftode E, Luca C, Badescu A, Dorneanu O, Iancu LS. Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis. Rev. Chim.[internet]. 2018 Jan;69(1):241-247. Available from: https://doi.org/10.37358/RC.18.1.6081


APA 6th edition
Plesca, C., Manciuc, C., Miftode, E., Luca, C., Badescu, A., Dorneanu, O. & Iancu, L.S. (2018). Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis. Revista de Chimie, 69(1), 241-247. https://doi.org/10.37358/RC.18.1.6081


Harvard
Plesca, C., Manciuc, C., Miftode, E., Luca, C., Badescu, A., Dorneanu, O., Iancu, L.S. (2018). 'Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis', Revista de Chimie, 69(1), pp. 241-247. https://doi.org/10.37358/RC.18.1.6081


IEEE
C. Plesca, C. Manciuc, E. Miftode, C. Luca, A. Badescu, O. Dorneanu, L.S. Iancu, "Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis". Revista de Chimie, vol. 69, no. 1, pp. 241-247, 2018. [online]. https://doi.org/10.37358/RC.18.1.6081


Text
Claudia Plesca, Carmen Manciuc, Egidia Miftode, Catalina Luca, Aida Badescu, Olivia Dorneanu, Luminita Smaranda Iancu,
Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis,
Revista de Chimie,
Volume 69, Issue 1,
2018,
Pages 241-247,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.1.6081.
(https://revistadechimie.ro/Articles.asp?ID=6081)
Keywords: Severe sepsis; HIV Immunodepression; Antibiotherapy


RIS
TY - JOUR
T1 - Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis
A1 - Plesca, Claudia
A2 - Manciuc, Carmen
A3 - Miftode, Egidia
A4 - Luca, Catalina
A5 - Badescu, Aida
A6 - Dorneanu, Olivia
A7 - Iancu, Luminita Smaranda
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 1
SP - 241
EP - 247
UR - https://doi.org/10.37358/RC.18.1.6081
KW - Severe sepsis
KW - HIV Immunodepression
KW - Antibiotherapy
ER -


BibTex
@article{RevCh2018P241,
author = {Plesca Claudia and Manciuc Carmen and Miftode Egidia and Luca Catalina and Badescu Aida and Dorneanu Olivia and Iancu Luminita Smaranda},
title = {Predictive Value of Laboratory Markers in HIV-Positive Patient Diagnosed With Severe Sepsis},
journal = {Revista de Chimie},
volume = {69},
number = {1},
pages = {241-247},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.1.6081},
url = {https://revistadechimie.ro/Articles.asp?ID=6081}
}
 
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