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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 1, 259-266

https://doi.org/10.37358/RC.18.1.6085

Gheorghe Maria, Andreea Georgiana Scoban

Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II

Abstract:

While in the first part of the study, general concepts of the novel whole-cell simulation of metabolic processes in living cells are presented, by considering a variable-volume modelling framework, in the present paper exemplification is made for approaching several case studies when building-up modular model structures, for instance by developing modular kinetic representations of the homeostatic gene expression regulatory modules (GERM) that control the protein synthesis and homeostasis of metabolic processes. Past and current experience with GERM linking rules is presented in order to point-out how optimized globally efficient kinetic models for the genetic regulatory circuits (GRC) can be obtained to reproduce experimental observations. Based on quantitative regulatory indices evaluated vs. simulated dynamic and stationary environmental perturbations, the paper exemplifies with GERM-s from E. coli, at a generic level, how this methodology can be extended to characterize the GERM module efficiency, species connectivity, and system stability.
Keywords:
kinetic modelling of cell protein synthesis; homeostatic regulation; gene expression regulatory modules (GERM); linking GERM-s

Issue: 2018, Volume 69, Issue 1
Pages: 259-266
Publication date: 15/02/2018
https://doi.org/10.37358/RC.18.1.6085
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MARIA, G., SCOBAN, A.G., Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II, Rev. Chim., 69(1), 2018, 259-266.

Vancouver
Maria G, Scoban AG. Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II. Rev. Chim.[internet]. 2018 Jan;69(1):259-266. Available from: https://doi.org/10.37358/RC.18.1.6085


APA 6th edition
Maria, G., Scoban, A.G. (2018). Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II. Revista de Chimie, 69(1), 259-266. https://doi.org/10.37358/RC.18.1.6085


Harvard
Maria, G., Scoban, A.G. (2018). 'Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II', Revista de Chimie, 69(1), pp. 259-266. https://doi.org/10.37358/RC.18.1.6085


IEEE
G. Maria, A.G. Scoban, "Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II". Revista de Chimie, vol. 69, no. 1, pp. 259-266, 2018. [online]. https://doi.org/10.37358/RC.18.1.6085


Text
Gheorghe Maria, Andreea Georgiana Scoban,
Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II,
Revista de Chimie,
Volume 69, Issue 1,
2018,
Pages 259-266,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.1.6085.
(https://revistadechimie.ro/Articles.asp?ID=6085)
Keywords: kinetic modelling of cell protein synthesis; homeostatic regulation; gene expression regulatory modules (GERM); linking GERM-s


RIS
TY - JOUR
T1 - Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II
A1 - Maria, Gheorghe
A2 - Scoban, Andreea Georgiana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 1
SP - 259
EP - 266
UR - https://doi.org/10.37358/RC.18.1.6085
KW - kinetic modelling of cell protein synthesis; homeostatic regulation; gene expression regulatory modules (GERM); linking GERM-s
ER -


BibTex
@article{RevCh2018P259,
author = {Maria Gheorghe and Scoban Andreea Georgiana},
title = {Setting Some Milestones when Modelling Cell Gene Expression Regulatory Circuits Under Variable-volume Whole-cell Modelling Framework. II},
journal = {Revista de Chimie},
volume = {69},
number = {1},
pages = {259-266},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.1.6085},
url = {https://revistadechimie.ro/Articles.asp?ID=6085}
}
 
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