The Effect of Some Natural Cytotoxic Peptides on Tumor Cells

Diaconescu, Bogdan Mihail; Jitaru, Daniela; Dragos, Mihaiela Loredana; Badescu, Magda; Stefanache, Teodor; Ciocoiu, Manuela; Mocanu, Madalina; Badescu, Codruta

Bogdan Mihail Diaconescu, Daniela Jitaru, Mihaiela Loredana Dragos, Magda Badescu, Teodor Stefanache, Manuela Ciocoiu, Madalina Mocanu, Codruta Badescu

The Effect of Some Natural Cytotoxic Peptides on Tumor Cells

Abstract:

Many studies have highlighted the anti-tumor properties of some natural peptides known to have antimicrobial virtues. In this study, we evaluated the tumoricidal potential of dermaseptin, defensin, cecropin A and B on tumor cell lines: M14K (human mesothelioma). The viability study was performed using PE V Annexin and 7-AAD (7-amino-actinomycin D) (BD Pharmingen). This test was used to detect and measure apoptosis by flow cytometry technique. The experimental results of our study revealed that the cytotoxic effects of the four peptides depend on their concentration. In this in vitro experimental study, we found that the cytotoxic effect of the four cytotoxic peptides used depended on their concentration in the tumor cell culture medium, being significant at concentrations of 120mM and maintained at concentrations of 60ìM. At 30ìM concentrations these tumoricidal effects were insignificant. Of all the studied peptides, dermaseptin has the most powerful effect and the weakest effect b - defensin - 1.

Keywords:
dermaseptin; defensin; cecropin; human mesothelioma

Issue: 2018, Volume 69, Issue 3

Pages: 597-601

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6157

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DIACONESCU, B.M., JITARU, D., DRAGOS, M.L., BADESCU, M., STEFANACHE, T., CIOCOIU, M., MOCANU, M., BADESCU, C., The Effect of Some Natural Cytotoxic Peptides on Tumor Cells, Rev. Chim., 69(3), 2018, 597-601.

Vancouver
Diaconescu BM, Jitaru D, Dragos ML, Badescu M, Stefanache T, Ciocoiu M, Mocanu M, Badescu C. The Effect of Some Natural Cytotoxic Peptides on Tumor Cells. Rev. Chim.[internet]. 2018 Mar;69(3):597-601. Available from: https://doi.org/10.37358/RC.18.3.6157

APA 6th edition
Diaconescu, B.M., Jitaru, D., Dragos, M.L., Badescu, M., Stefanache, T., Ciocoiu, M., Mocanu, M. & Badescu, C. (2018). The Effect of Some Natural Cytotoxic Peptides on Tumor Cells. Revista de Chimie, 69(3), 597-601. https://doi.org/10.37358/RC.18.3.6157

Harvard
Diaconescu, B.M., Jitaru, D., Dragos, M.L., Badescu, M., Stefanache, T., Ciocoiu, M., Mocanu, M., Badescu, C. (2018). 'The Effect of Some Natural Cytotoxic Peptides on Tumor Cells', Revista de Chimie, 69(3), pp. 597-601. https://doi.org/10.37358/RC.18.3.6157

IEEE
B.M. Diaconescu, D. Jitaru, M.L. Dragos, M. Badescu, T. Stefanache, M. Ciocoiu, M. Mocanu, C. Badescu, "The Effect of Some Natural Cytotoxic Peptides on Tumor Cells". Revista de Chimie, vol. 69, no. 3, pp. 597-601, 2018. [online]. https://doi.org/10.37358/RC.18.3.6157

Text
Bogdan Mihail Diaconescu, Daniela Jitaru, Mihaiela Loredana Dragos, Magda Badescu, Teodor Stefanache, Manuela Ciocoiu, Madalina Mocanu, Codruta Badescu,
The Effect of Some Natural Cytotoxic Peptides on Tumor Cells,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 597-601,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6157.
(https://revistadechimie.ro/Articles.asp?ID=6157)
Keywords: dermaseptin; defensin; cecropin; human mesothelioma

RIS
TY - JOUR
T1 - The Effect of Some Natural Cytotoxic Peptides on Tumor Cells
A1 - Diaconescu, Bogdan Mihail
A2 - Jitaru, Daniela
A3 - Dragos, Mihaiela Loredana
A4 - Badescu, Magda
A5 - Stefanache, Teodor
A6 - Ciocoiu, Manuela
A7 - Mocanu, Madalina
A8 - Badescu, Codruta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 597
EP - 601
UR - https://doi.org/10.37358/RC.18.3.6157
KW - dermaseptin
KW - defensin
KW - cecropin
KW - human mesothelioma
ER -

BibTex
@article{RevCh2018P597,
author = {Diaconescu Bogdan Mihail and Jitaru Daniela and Dragos Mihaiela Loredana and Badescu Magda and Stefanache Teodor and Ciocoiu Manuela and Mocanu Madalina and Badescu Codruta},
title = {The Effect of Some Natural Cytotoxic Peptides on Tumor Cells},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {597-601},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6157},
url = {https://revistadechimie.ro/Articles.asp?ID=6157}
}

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