Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment

Ageu, Luminita; Talpos, Cristina; Kanalas, Ghizela; Crisan, Simina; Zamfir, Carmen Lacramioara; Poroch, Vladimir; Anghel, Mirela

Luminita Ageu, Cristina Talpos, Ghizela Kanalas, Simina Crisan, Carmen Lacramioara Zamfir, Vladimir Poroch, Mirela Anghel

Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment

Abstract:

We approach the theme of modern investigation and treatment strategies, based on biochemical, clinical-biological, metabolic, pharmacogenetic, neuro-imagistic, and neuroendocrine integrative correlations in the management of depressive disorders. Our main objective was to investigate: the biochemical brain metabolites [N-acetyl-aspartate (NAA), gamma-aminobutyric acid (GABA), aspartate (Asp), creatine (CR), glutamine (Gln), glicerophosphocholine (GPC), phosphocholine (PC), phosphocreatine (PCr), taurine (Tau), N-methyl-D-aspartate (N-MDA), serine, glycine, choline (Cho)]; the neuroimagistic and neurobiological markers and the metabolic abnormalities in correlation with the molecular pharmacogenetic testing in children and adolescents treated with antidepressant medication. Our research was conducted between 2009-2016 on 90 children and adolescents with depressive disorders -45 children-G1, who benefited of pharmacogenetic testing tailored pharmacotherapy, and 45 without pharmacogenetic testing-G2. The patients were also evaluated by MR spectroscopy at baseline and after pharmacotherapy. The efficacy of the chosen therapy in correlation with the pharmacogenetic testing was evaluated by the mean change in the CDRS (Child Depression Rating Scale) total scores, in the CGI-S/I (Clinical Global Impression Severity/Improvement), CGAS (Clinical Global Assessment of Functioning) and by the change of the relevant neurobiological markers and MR spectroscopy biochemical brain metabolites. Our results showed statistically significant differences in the clinical scores between the studied groups. Our research could represent a proof that the biochemical brain metabolites registered in depressive disorders modified values in the MR spectroscopy and the administration of antidepressants could determine metabolic and neuroendocrine abnormalities (changed lipid profiles, high insulin and plasma glucose levels, weight gain, obesity), especially when chosen without prior pharmacogenetic testing.

Keywords:
biochemical metabolites; N-acetyl aspartate (NAA); gama-aminobutyric acid (GABA); metabolic abnormalities; antidepressants; pharmacogenetic testing

Issue: 2018, Volume 69, Issue 3

Pages: 621-626

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6162

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
AGEU, L., TALPOS, C., KANALAS, G., CRISAN, S., ZAMFIR, C.L., POROCH, V., ANGHEL, M., Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment, Rev. Chim., 69(3), 2018, 621-626.

Vancouver
Ageu L, Talpos C, Kanalas G, Crisan S, Zamfir CL, Poroch V, Anghel M. Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment. Rev. Chim.[internet]. 2018 Mar;69(3):621-626. Available from: https://doi.org/10.37358/RC.18.3.6162

APA 6th edition
Ageu, L., Talpos, C., Kanalas, G., Crisan, S., Zamfir, C.L., Poroch, V. & Anghel, M. (2018). Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment. Revista de Chimie, 69(3), 621-626. https://doi.org/10.37358/RC.18.3.6162

Harvard
Ageu, L., Talpos, C., Kanalas, G., Crisan, S., Zamfir, C.L., Poroch, V., Anghel, M. (2018). 'Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment', Revista de Chimie, 69(3), pp. 621-626. https://doi.org/10.37358/RC.18.3.6162

IEEE
L. Ageu, C. Talpos, G. Kanalas, S. Crisan, C.L. Zamfir, V. Poroch, M. Anghel, "Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment". Revista de Chimie, vol. 69, no. 3, pp. 621-626, 2018. [online]. https://doi.org/10.37358/RC.18.3.6162

Text
Luminita Ageu, Cristina Talpos, Ghizela Kanalas, Simina Crisan, Carmen Lacramioara Zamfir, Vladimir Poroch, Mirela Anghel,
Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 621-626,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6162.
(https://revistadechimie.ro/Articles.asp?ID=6162)
Keywords: biochemical metabolites; N-acetyl aspartate (NAA); gama-aminobutyric acid (GABA); metabolic abnormalities; antidepressants; pharmacogenetic testing

RIS
TY - JOUR
T1 - Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment
A1 - Ageu, Luminita
A2 - Talpos, Cristina
A3 - Kanalas, Ghizela
A4 - Crisan, Simina
A5 - Zamfir, Carmen Lacramioara
A6 - Poroch, Vladimir
A7 - Anghel, Mirela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 621
EP - 626
UR - https://doi.org/10.37358/RC.18.3.6162
KW - biochemical metabolites
KW - N-acetyl aspartate (NAA)
KW - gama-aminobutyric acid (GABA)
KW - metabolic abnormalities
KW - antidepressants
KW - pharmacogenetic testing
ER -

BibTex
@article{RevCh2018P621,
author = {Ageu Luminita and Talpos Cristina and Kanalas Ghizela and Crisan Simina and Zamfir Carmen Lacramioara and Poroch Vladimir and Anghel Mirela},
title = {Correlations Between Neuroendocrine Disorders and Biochemical Brain Metabolites Alterations in Antidepressant Treatment},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {621-626},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6162},
url = {https://revistadechimie.ro/Articles.asp?ID=6162}
}

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