Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus

Stanescu, Iulia Ioana; Calenic, Bogdan; Dima, Alina; Miricescu, Daniela; Badita, Daniela Gabriela; Baicus, Cristian; Balanescu, Paul; Balanescu, Eugenia; Perlea, Paula; Greabu, Maria

Iulia Ioana Stanescu, Bogdan Calenic, Alina Dima, Daniela Miricescu, Daniela Gabriela Badita, Cristian Baicus, Paul Balanescu, Eugenia Balanescu, Paula Perlea, Maria Greabu

Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus

Abstract:

Saliva is a remarkable diagnostic fluid being used to monitor a wide range of local and systemic diseases. Autoimmune diseases represent a major health threat to women worldwide with sexual hormones acting as co-factors for these pathologies and interfering with the normal immune response. The main aim of our study was to evaluate salivary levels of testosterone (T2) and 17-b estradiol (E2) in several autoimmune diseases with a special focus on systemic lupus erythematosus (SLE). The study included 45 SLE patients, 15 patients with other autoimmune diseases and 10 healthy subjects. Salivary T2 and E2 levels were determined using ELISA assays. Salivary E2 levels in female SLE patients were significantly increased versus vasculitis female patients. Positive correlations have been found between salivary E2 levels and important clinical parameters such as age at inclusion and duration of corticosteroid treatment. E2 salivary level was also identified as an independent predictor of lupus renal nephritis. Regarding T2, salivary levels were found to be significantly lower in SLE female patients compared to respective controls. Furthermore, positive statistical correlations were found between T2 and E2 salivary levels. Collectively, these results promote the use of saliva as a monitoring fluid for hormonal activity in SLE.

Keywords:
saliva; autoimmune diseases; 17-b estradiol; testosterone

Issue: 2018, Volume 69, Issue 3

Pages: 654-659

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6169

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STANESCU, I.I., CALENIC, B., DIMA, A., MIRICESCU, D., BADITA, D.G., BAICUS, C., BALANESCU, P., BALANESCU, E., PERLEA, P., GREABU, M., Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus, Rev. Chim., 69(3), 2018, 654-659.

Vancouver
Stanescu II, Calenic B, Dima A, Miricescu D, Badita DG, Baicus C, Balanescu P, Balanescu E, Perlea P, Greabu M. Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus. Rev. Chim.[internet]. 2018 Mar;69(3):654-659. Available from: https://doi.org/10.37358/RC.18.3.6169

APA 6th edition
Stanescu, I.I., Calenic, B., Dima, A., Miricescu, D., Badita, D.G., Baicus, C.,... Greabu, M. (2018). Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus. Revista de Chimie, 69(3), 654-659. https://doi.org/10.37358/RC.18.3.6169

Harvard
Stanescu, I.I., Calenic, B., Dima, A., Miricescu, D., Badita, D.G., Baicus, C., Balanescu, P., Balanescu, E., Perlea, P., Greabu, M. (2018). 'Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus', Revista de Chimie, 69(3), pp. 654-659. https://doi.org/10.37358/RC.18.3.6169

IEEE
I.I. Stanescu, B. Calenic, A. Dima, D. Miricescu, D.G. Badita, C. Baicus, P. Balanescu, E. Balanescu, P. Perlea, M. Greabu, "Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus". Revista de Chimie, vol. 69, no. 3, pp. 654-659, 2018. [online]. https://doi.org/10.37358/RC.18.3.6169

Text
Iulia Ioana Stanescu, Bogdan Calenic, Alina Dima, Daniela Miricescu, Daniela Gabriela Badita, Cristian Baicus, Paul Balanescu, Eugenia Balanescu, Paula Perlea, Maria Greabu,
Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 654-659,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6169.
(https://revistadechimie.ro/Articles.asp?ID=6169)
Keywords: saliva; autoimmune diseases; 17-b estradiol; testosterone

RIS
TY - JOUR
T1 - Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus
A1 - Stanescu, Iulia Ioana
A2 - Calenic, Bogdan
A3 - Dima, Alina
A4 - Miricescu, Daniela
A5 - Badita, Daniela Gabriela
A6 - Baicus, Cristian
A7 - Balanescu, Paul
A8 - Balanescu, Eugenia
A9 - Perlea, Paula
A10 - Greabu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 654
EP - 659
UR - https://doi.org/10.37358/RC.18.3.6169
KW - saliva
KW - autoimmune diseases
KW - 17-b estradiol
KW - testosterone
ER -

BibTex
@article{RevCh2018P654,
author = {Stanescu Iulia Ioana and Calenic Bogdan and Dima Alina and Miricescu Daniela and Badita Daniela Gabriela and Baicus Cristian and Balanescu Paul and Balanescu Eugenia and Perlea Paula and Greabu Maria},
title = {Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {654-659},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6169},
url = {https://revistadechimie.ro/Articles.asp?ID=6169}
}

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