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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 4, 815-822

https://doi.org/10.37358/RC.18.4.6207

Lucia Pintilie, Amalia Stefaniu, Alina Ioana Nicu, Maria Maganu, Miron Teodor Caproiu

Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity

Abstract:

A new series of fluoroquinolone compounds have been obtained by Gould-Jacobs method. The compounds have been characterized by physic-chemical methods (elemental analysis, FTIR, NMR, UV-Vis) and by antimicrobial activity against Gram-positive and Gram-negative microorganisms. For the synthesized compounds have been performed calculations of characteristics and molecular properties, using Spartan’14 Software from Wavefunction, Inc. Irvine, CA. and molecular docking studies using CLC Drug Discovery Workbench 2.4 software, to identify and visualize the most likely interaction ligand (fluoroquinolone) with the receptor protein.
Keywords:
quinolones; fluoroquinolones; antimicrobial activity; molecular docking

Issue: 2018, Volume 69, Issue 4
Pages: 815-822
Publication date: 2018/5/15
https://doi.org/10.37358/RC.18.4.6207
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PINTILIE, L., STEFANIU, A., NICU, A.I., MAGANU, M., CAPROIU, M.T., Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity, Rev. Chim., 69(4), 2018, 815-822.

Vancouver
Pintilie L, Stefaniu A, Nicu AI, Maganu M, Caproiu MT. Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity. Rev. Chim.[internet]. 2018 Apr;69(4):815-822. Available from: https://doi.org/10.37358/RC.18.4.6207


APA 6th edition
Pintilie, L., Stefaniu, A., Nicu, A.I., Maganu, M. & Caproiu, M.T. (2018). Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity. Revista de Chimie, 69(4), 815-822. https://doi.org/10.37358/RC.18.4.6207


Harvard
Pintilie, L., Stefaniu, A., Nicu, A.I., Maganu, M., Caproiu, M.T. (2018). 'Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity', Revista de Chimie, 69(4), pp. 815-822. https://doi.org/10.37358/RC.18.4.6207


IEEE
L. Pintilie, A. Stefaniu, A.I. Nicu, M. Maganu, M.T. Caproiu, "Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity". Revista de Chimie, vol. 69, no. 4, pp. 815-822, 2018. [online]. https://doi.org/10.37358/RC.18.4.6207


Text
Lucia Pintilie, Amalia Stefaniu, Alina Ioana Nicu, Maria Maganu, Miron Teodor Caproiu,
Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 815-822,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6207.
(https://revistadechimie.ro/Articles.asp?ID=6207)
Keywords: quinolones; fluoroquinolones; antimicrobial activity; molecular docking


RIS
TY - JOUR
T1 - Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity
A1 - Pintilie, Lucia
A2 - Stefaniu, Amalia
A3 - Nicu, Alina Ioana
A4 - Maganu, Maria
A5 - Caproiu, Miron Teodor
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 815
EP - 822
UR - https://doi.org/10.37358/RC.18.4.6207
KW - quinolones
KW - fluoroquinolones
KW - antimicrobial activity
KW - molecular docking
ER -


BibTex
@article{RevCh2018P815,
author = {Pintilie Lucia and Stefaniu Amalia and Nicu Alina Ioana and Maganu Maria and Caproiu Miron Teodor},
title = {Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {815-822},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6207},
url = {https://revistadechimie.ro/Articles.asp?ID=6207}
}
 
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