Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease

Decusara, Mioara; Romila, Aurelia; Pavel, Liliana; Andrei, Lucian Laurentiu; Negraia, Magdalena Rusu; Macovei, Luana Andreea

Mioara Decusara, Aurelia Romila, Liliana Pavel, Lucian Laurentiu Andrei, Magdalena Rusu Negraia, Luana Andreea Macovei

Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease

Abstract:

Calcium is involved in many biological processes. Hydroxyapatite provides bone mineralization, maintains cellular signaling, enzyme activity, nerve impulse transmission, muscle contraction and regulates blood clotting and membrane permeability. Calcium depositions may be caused by necrosis following trauma, connective tissue diseases, metabolic diseases, sarcoidosis, myeloma, metastases, chondrocalcinosis or calcium pyrophosphate dihydrate crystal deposition disease, cervical spondylosis, ankylosing spondylitis, ossification of the posterior longitudinal ligament of the spine and Forestier’s disease. Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier-Rotes-Querrol’s disease is characterized by calcification of ligaments and entheses of the anterior vertebrae in the thoracic spine and sacroiliac joint bridging caused by abnormal proliferation of osteoblasts. At least four consecutive thoracic vertebrae are affected and the intervertebral disc space is preserved. Peripheral joints of heels, knees, elbows and pelvis may be also affected. Diagnosis is confirmed by radiographic findings with a candlewax-like appearance down the spine, on C2-C6 vertebrae. A total number of 37 patients with a median age of 63 years, of which 24 were male (64.86%) and 13 female (35.14%), were diagnosed with DISH at the Clinic of Geriatry of Galati County Emergency Clinical Hospital Sf. Apostol Andrei between 2006-2016. Differential diagnosis included ankylosing spondylitis and spondylosis deformans. DISH was found in patients aged over 50 years, with obesity and diabetes, based on radiographic findings. Drug therapy and physical therapy successfully provided pain relief, increased axial and peripheral mobility, improved physical function and optimal quality of life. None of our patients required surgery, as there were no cases with compromised airways and digestive tract involvement. Our study confirms that old age, obesity and type 2 diabetes are risk factors for diffuse idiopathic skeletal hyperostosis.

Keywords:
hydroxyapatite; calcium deposits; Forestier’s disease; hyperostosis

Issue: 2018, Volume 69, Issue 5

Pages: 1254-1256

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6301

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DECUSARA, M., ROMILA, A., PAVEL, L., ANDREI, L.L., NEGRAIA, M.R., MACOVEI, L.A., Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease, Rev. Chim., 69(5), 2018, 1254-1256.

Vancouver
Decusara M, Romila A, Pavel L, Andrei LL, Negraia MR, Macovei LA. Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease. Rev. Chim.[internet]. 2018 May;69(5):1254-1256. Available from: https://doi.org/10.37358/RC.18.5.6301

APA 6th edition
Decusara, M., Romila, A., Pavel, L., Andrei, L.L., Negraia, M.R. & Macovei, L.A. (2018). Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease. Revista de Chimie, 69(5), 1254-1256. https://doi.org/10.37358/RC.18.5.6301

Harvard
Decusara, M., Romila, A., Pavel, L., Andrei, L.L., Negraia, M.R., Macovei, L.A. (2018). 'Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease', Revista de Chimie, 69(5), pp. 1254-1256. https://doi.org/10.37358/RC.18.5.6301

IEEE
M. Decusara, A. Romila, L. Pavel, L.L. Andrei, M.R. Negraia, L.A. Macovei, "Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease". Revista de Chimie, vol. 69, no. 5, pp. 1254-1256, 2018. [online]. https://doi.org/10.37358/RC.18.5.6301

Text
Mioara Decusara, Aurelia Romila, Liliana Pavel, Lucian Laurentiu Andrei, Magdalena Rusu Negraia, Luana Andreea Macovei,
Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1254-1256,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6301.
(https://revistadechimie.ro/Articles.asp?ID=6301)
Keywords: hydroxyapatite; calcium deposits; Forestier’s disease; hyperostosis

RIS
TY - JOUR
T1 - Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease
A1 - Decusara, Mioara
A2 - Romila, Aurelia
A3 - Pavel, Liliana
A4 - Andrei, Lucian Laurentiu
A5 - Negraia, Magdalena Rusu
A6 - Macovei, Luana Andreea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1254
EP - 1256
UR - https://doi.org/10.37358/RC.18.5.6301
KW - hydroxyapatite
KW - calcium deposits
KW - Forestier’s disease
KW - hyperostosis
ER -

BibTex
@article{RevCh2018P1254,
author = {Decusara Mioara and Romila Aurelia and Pavel Liliana and Andrei Lucian Laurentiu and Negraia Magdalena Rusu and Macovei Luana Andreea},
title = {Chemical Changes Caused by Calcium Deposition in Forestier - Rotes - Querrol’s Disease},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1254-1256},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6301},
url = {https://revistadechimie.ro/Articles.asp?ID=6301}
}

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