The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women

Mihalceanu, Elena; Dimitriu, Daniela Cristina; Lazar, Ioan Tudor; Petre, Brindusa Alina; Constantinescu, Gabriel; Nemescu, Dragos; Scripcariu, Ioana

Elena Mihalceanu, Daniela Cristina Dimitriu, Ioan Tudor Lazar, Brindusa Alina Petre, Gabriel Constantinescu, Dragos Nemescu, Ioana Scripcariu

The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women

Abstract:

The objectives of the research herein are to detect if the modifications of sFlt-1 and PlGF can be correlated with the clinical and biochemical status of the hypertensive pregnant woman and if the sFlt-1/PlGF ratio is a good predictor for preeclampsia in case of the investigated patients. In the study herein, 100 pregnant women were evaluated; they were distributed in the following groups: The group of pregnant women diagnosed with HTN at the time of hospital admission - including 50 pregnant women, of which 16 pregnant women presented medium and severe forms of preeclampsia and 34 pregnant women with pregnancy-induced hypertension and 50 pregnant women with normal pregnancy evolution as control group. We have performed hematological and biochemical tests, using serum samples from all analyzed patients and measured the serum concentrations of sFlt-1 and PlGF angiogenic factors. We found a significant correlation between the value of the arterial blood pressure, the proteinuria, the serum creatinine and the AST, on one hand, and the sFlt-1/PlGF ratio, on the other hand. The ROC curve has emphasized the fact that the proteinuria (AUC = 0.849), the AST (AUC = 0.664), the value of the arterial blood pressure SBP/DBP (AUC = 0.683/0.631), the serum creatinine (AUC = 0.674) and the sFlt-1/PlGF ratio, at a cut off value = 200, are effective preeclampsia predictors. Similarly, statistically significant increase (p = 0.001) of the sFlt-1 serum concentration in case of the pregnant women from the PE group (14365±6464 pg/mL) and from the PIH group (9892±8443 pg/mL), compared to the control group (3278±1444 pg/mL) and, respectively, a significant decrease (p = 0.003) of the PlGF pro-angiogenic marker for the group of pregnant women suffering from preeclampsia (119.30±56.63 pg/mL) and from PIH (129.12±21.41 pg/mL), compared to the control group (327.57±59.62 pg/mL). The results obtained within this research show that sFlt-1/PlGF ratio represents an effective preeclampsia predictor, confirming the fact that the study of the angiogenic factors may help to analyze the stratification of the risk degree in HTN pregnant women.

Keywords:
soluble fms-like tyrosine kinase-1(sFlt-1); pro-angiogenic placental growth (PlGF); preeclampsia; gestational hypertension

Issue: 2018, Volume 69, Issue 6

Pages: 1509-1514

Publication date: 2018/7/15

https://doi.org/10.37358/RC.18.6.6357

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Citation Styles

Cite this article as:
MIHALCEANU, E., DIMITRIU, D.C., LAZAR, I.T., PETRE, B.A., CONSTANTINESCU, G., NEMESCU, D., SCRIPCARIU, I., The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women, Rev. Chim., 69(6), 2018, 1509-1514.

Vancouver
Mihalceanu E, Dimitriu DC, Lazar IT, Petre BA, Constantinescu G, Nemescu D, Scripcariu I. The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women. Rev. Chim.[internet]. 2018 Jun;69(6):1509-1514. Available from: https://doi.org/10.37358/RC.18.6.6357

APA 6th edition
Mihalceanu, E., Dimitriu, D.C., Lazar, I.T., Petre, B.A., Constantinescu, G., Nemescu, D. & Scripcariu, I. (2018). The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women. Revista de Chimie, 69(6), 1509-1514. https://doi.org/10.37358/RC.18.6.6357

Harvard
Mihalceanu, E., Dimitriu, D.C., Lazar, I.T., Petre, B.A., Constantinescu, G., Nemescu, D., Scripcariu, I. (2018). 'The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women', Revista de Chimie, 69(6), pp. 1509-1514. https://doi.org/10.37358/RC.18.6.6357

IEEE
E. Mihalceanu, D.C. Dimitriu, I.T. Lazar, B.A. Petre, G. Constantinescu, D. Nemescu, I. Scripcariu, "The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women". Revista de Chimie, vol. 69, no. 6, pp. 1509-1514, 2018. [online]. https://doi.org/10.37358/RC.18.6.6357

Text
Elena Mihalceanu, Daniela Cristina Dimitriu, Ioan Tudor Lazar, Brindusa Alina Petre, Gabriel Constantinescu, Dragos Nemescu, Ioana Scripcariu,
The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women,
Revista de Chimie,
Volume 69, Issue 6,
2018,
Pages 1509-1514,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.6.6357.
(https://revistadechimie.ro/Articles.asp?ID=6357)
Keywords: soluble fms-like tyrosine kinase-1(sFlt-1); pro-angiogenic placental growth (PlGF); preeclampsia; gestational hypertension

RIS
TY - JOUR
T1 - The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women
A1 - Mihalceanu, Elena
A2 - Dimitriu, Daniela Cristina
A3 - Lazar, Ioan Tudor
A4 - Petre, Brindusa Alina
A5 - Constantinescu, Gabriel
A6 - Nemescu, Dragos
A7 - Scripcariu, Ioana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 6
SP - 1509
EP - 1514
UR - https://doi.org/10.37358/RC.18.6.6357
KW - soluble fms-like tyrosine kinase-1(sFlt-1)
KW - pro-angiogenic placental growth (PlGF)
KW - preeclampsia
KW - gestational hypertension
ER -

BibTex
@article{RevCh2018P1509,
author = {Mihalceanu Elena and Dimitriu Daniela Cristina and Lazar Ioan Tudor and Petre Brindusa Alina and Constantinescu Gabriel and Nemescu Dragos and Scripcariu Ioana},
title = {The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women},
journal = {Revista de Chimie},
volume = {69},
number = {6},
pages = {1509-1514},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.6.6357},
url = {https://revistadechimie.ro/Articles.asp?ID=6357}
}

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