Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia

Ivan, Viviana Mihaela; Georgescu, Marius; Apostol, Adrian; Albulescu, Nicolae; Serb, Alina Florina; Tatu, Carmen Sofica

Viviana Mihaela Ivan, Marius Georgescu, Adrian Apostol, Nicolae Albulescu, Alina Florina Serb, Carmen Sofica Tatu

Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia

Abstract:

Metabolic therapy constitutes a relatively new therapeutic option for ischemic heart disease (IHD). Metabolic agents including Trimetazidine [1-(2,3,4-trimethoxybenzyl) piperazine] (TMZ) are currently used as anti-ischemic cardiac drugs to alleviate this internal metabolic disturbance. The present study focused on the assessment of the beneficial effects of TMZ as additional medication to the conventional medical therapy in patients with myocardial infarction. The obtained results showed an increase of superoxide dismutase (SOD) activities and a faster normalization of total sialic acid (TSA) levels in patients with TMZ add-on therapy, in comparison to the control group, indicating a stabilization of the ischemic process under TMZ therapy, with decreased free radical production and restoration of the antioxidant capacity and of the membrane lesions. The present findings emphasize the importance of TMZ administration to prevent reperfusion-mediated cardiac injury and dysfunction and demonstrate that this promising therapeutic approach is worthy of further research.

Keywords:
Trimetazidine (TMZ); myocardial infarction; sialic acid; superoxide dismutase; metabolic modulators

Issue: 2018, Volume 69, Issue 7

Pages: 1616-1620

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6382

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IVAN, V.M., GEORGESCU, M., APOSTOL, A., ALBULESCU, N., SERB, A.F., TATU, C.S., Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia, Rev. Chim., 69(7), 2018, 1616-1620.

Vancouver
Ivan VM, Georgescu M, Apostol A, Albulescu N, Serb AF, Tatu CS. Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia. Rev. Chim.[internet]. 2018 Jul;69(7):1616-1620. Available from: https://doi.org/10.37358/RC.18.7.6382

APA 6th edition
Ivan, V.M., Georgescu, M., Apostol, A., Albulescu, N., Serb, A.F. & Tatu, C.S. (2018). Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia. Revista de Chimie, 69(7), 1616-1620. https://doi.org/10.37358/RC.18.7.6382

Harvard
Ivan, V.M., Georgescu, M., Apostol, A., Albulescu, N., Serb, A.F., Tatu, C.S. (2018). 'Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia', Revista de Chimie, 69(7), pp. 1616-1620. https://doi.org/10.37358/RC.18.7.6382

IEEE
V.M. Ivan, M. Georgescu, A. Apostol, N. Albulescu, A.F. Serb, C.S. Tatu, "Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia". Revista de Chimie, vol. 69, no. 7, pp. 1616-1620, 2018. [online]. https://doi.org/10.37358/RC.18.7.6382

Text
Viviana Mihaela Ivan, Marius Georgescu, Adrian Apostol, Nicolae Albulescu, Alina Florina Serb, Carmen Sofica Tatu,
Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1616-1620,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6382.
(https://revistadechimie.ro/Articles.asp?ID=6382)
Keywords: Trimetazidine (TMZ); myocardial infarction; sialic acid; superoxide dismutase; metabolic modulators

RIS
TY - JOUR
T1 - Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia
A1 - Ivan, Viviana Mihaela
A2 - Georgescu, Marius
A3 - Apostol, Adrian
A4 - Albulescu, Nicolae
A5 - Serb, Alina Florina
A6 - Tatu, Carmen Sofica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1616
EP - 1620
UR - https://doi.org/10.37358/RC.18.7.6382
KW - Trimetazidine (TMZ)
KW - myocardial infarction
KW - sialic acid
KW - superoxide dismutase
KW - metabolic modulators
ER -

BibTex
@article{RevCh2018P1616,
author = {Ivan Viviana Mihaela and Georgescu Marius and Apostol Adrian and Albulescu Nicolae and Serb Alina Florina and Tatu Carmen Sofica},
title = {Trimetazidine, a Metabolic Modulator, with Cardioprotective Effects Against Myocardial Ischemia},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1616-1620},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6382},
url = {https://revistadechimie.ro/Articles.asp?ID=6382}
}

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