Collagen-the Ultrastructural Element of the Bone Matrix

Dumitru, Nicoleta; Cocolos, Andra; Caragheorgheopol, Andra; Dumitrache, Constantin; Bratu, Ovidiu Gabriel; Neagu, Tiberiu Paul; Diaconu, Camelia Cristina; Ghemigian, Adina

Nicoleta Dumitru, Andra Cocolos, Andra Caragheorgheopol, Constantin Dumitrache, Ovidiu Gabriel Bratu, Tiberiu Paul Neagu, Camelia Cristina Diaconu, Adina Ghemigian

Collagen-the Ultrastructural Element of the Bone Matrix

Abstract:

There is an increased interest and more studies highlight the fact that bone strength depends not only on bone tissue quantity, but also on its quality, which is characterized by the geometry and shape of bones, trabecular bone microarchitecture, mineral content, organic matrix and bone turnover. Fibrillar type I collagen is the major organic component of bone matrix, providing form and a stable template for mineralization. The biomedical importance of collagen as a biomaterial for medical and cosmetic purposes and the improvement of the molecular, cellular biology and analytical technologies, led to increasing interest in establishing the structure of this protein and in setting of the relationships between sequence, structure, and function. Bone collagen crosslinking chemistry and its molecular packing structure are considered to be distinct features. This unique post-translational modifications provide to the fibrillar collagen matrices properties such as tensile strength and viscoelasticity. Understanding the complex structure of bone type I collagen as well as the dynamic nature of bone tissues will help to manage new therapeutic approaches to bone diseases.

Keywords:
bone matrix; structural protein; type I collagen; cross-links; osteoporosis

Issue: 2018, Volume 69, Issue 7

Pages: 1706-1709

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6400

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Citation Styles

Cite this article as:
DUMITRU, N., COCOLOS, A., CARAGHEORGHEOPOL, A., DUMITRACHE, C., BRATU, O.G., NEAGU, T.P., DIACONU, C.C., GHEMIGIAN, A., Collagen-the Ultrastructural Element of the Bone Matrix, Rev. Chim., 69(7), 2018, 1706-1709.

Vancouver
Dumitru N, Cocolos A, Caragheorgheopol A, Dumitrache C, Bratu OG, Neagu TP, Diaconu CC, Ghemigian A. Collagen-the Ultrastructural Element of the Bone Matrix. Rev. Chim.[internet]. 2018 Jul;69(7):1706-1709. Available from: https://doi.org/10.37358/RC.18.7.6400

APA 6th edition
Dumitru, N., Cocolos, A., Caragheorgheopol, A., Dumitrache, C., Bratu, O.G., Neagu, T.P., Diaconu, C.C. & Ghemigian, A. (2018). Collagen-the Ultrastructural Element of the Bone Matrix. Revista de Chimie, 69(7), 1706-1709. https://doi.org/10.37358/RC.18.7.6400

Harvard
Dumitru, N., Cocolos, A., Caragheorgheopol, A., Dumitrache, C., Bratu, O.G., Neagu, T.P., Diaconu, C.C., Ghemigian, A. (2018). 'Collagen-the Ultrastructural Element of the Bone Matrix', Revista de Chimie, 69(7), pp. 1706-1709. https://doi.org/10.37358/RC.18.7.6400

IEEE
N. Dumitru, A. Cocolos, A. Caragheorgheopol, C. Dumitrache, O.G. Bratu, T.P. Neagu, C.C. Diaconu, A. Ghemigian, "Collagen-the Ultrastructural Element of the Bone Matrix". Revista de Chimie, vol. 69, no. 7, pp. 1706-1709, 2018. [online]. https://doi.org/10.37358/RC.18.7.6400

Text
Nicoleta Dumitru, Andra Cocolos, Andra Caragheorgheopol, Constantin Dumitrache, Ovidiu Gabriel Bratu, Tiberiu Paul Neagu, Camelia Cristina Diaconu, Adina Ghemigian,
Collagen-the Ultrastructural Element of the Bone Matrix,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1706-1709,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6400.
(https://revistadechimie.ro/Articles.asp?ID=6400)
Keywords: bone matrix; structural protein; type I collagen; cross-links; osteoporosis

RIS
TY - JOUR
T1 - Collagen-the Ultrastructural Element of the Bone Matrix
A1 - Dumitru, Nicoleta
A2 - Cocolos, Andra
A3 - Caragheorgheopol, Andra
A4 - Dumitrache, Constantin
A5 - Bratu, Ovidiu Gabriel
A6 - Neagu, Tiberiu Paul
A7 - Diaconu, Camelia Cristina
A8 - Ghemigian, Adina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1706
EP - 1709
UR - https://doi.org/10.37358/RC.18.7.6400
KW - bone matrix
KW - structural protein
KW - type I collagen
KW - cross-links
KW - osteoporosis
ER -

BibTex
@article{RevCh2018P1706,
author = {Dumitru Nicoleta and Cocolos Andra and Caragheorgheopol Andra and Dumitrache Constantin and Bratu Ovidiu Gabriel and Neagu Tiberiu Paul and Diaconu Camelia Cristina and Ghemigian Adina},
title = {Collagen-the Ultrastructural Element of the Bone Matrix},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1706-1709},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6400},
url = {https://revistadechimie.ro/Articles.asp?ID=6400}
}

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