Dental  Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study

Lucaciu, Ondine; Campian, Radu Septimiu; Soritau, Olga; Berce, Cristian; Mester, Alexandru; Apostu, Dragos; Tabaran, Flaviu; Manole, Marius; Bordea, Roxana; Ionel, Dan Cristian; Ionel, Anca

Ondine Lucaciu, Radu Septimiu Campian, Olga Soritau, Cristian Berce, Alexandru Mester, Dragos Apostu, Flaviu Tabaran, Marius Manole, Roxana Bordea, Dan Cristian Ionel, Anca Ionel

Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study

Abstract:

The goal of periodontal therapy is to regenerate the periodontal structures: cement, periodontal ligament and alveolar bone. Stem cell-based tissue engineering raised novel therapeutic strategies for periodontal repair. In vivo dental follicle stem (DFSC) cells give rise to cementoblasts, osteoblasts and fibroblasts. Based on this idea, we have assessed DFSC potential to regenerate the periodontal structures, and by that to elaborate a new biomaterial. An experimental study was performed on male Wistar rats which were subjected to a procedure of periodontitis induction through placing silk thread ligatures around the lower incisors, under general anesthesia. Clinically, the changes of the periodontal tissue (bleeding on probing, dental mobility, dental plaque, presence of pus) induced by the periodontitis progression were daily assessed. The subjects were divided in two groups: a control and a study group. After 7 days from placing silk thread ligatures, subjects from the study group received an injection in the gingival sulcus. The injected biomaterial contained dental follicle stem cells seeded on fibrinogen. Bleeding on probing at the end of the treatment period was significantly reduced in the study group (study vs control group - 0% vs 100%, p=0.01.). In terms of dental mobility statistical significant results were obtained (p=0.04): for 20% from the subjects from the study group dental mobility was absent, while in the control group all subjects presented different degrees of mobility (33.3% degree II- v-o/m-d, 66.6% degree III-v-o/m-d/ax). In the control group pus was present in 66.7% from the subjects, and absent in the study group (p=0.10). Dental plaque was present in 40% of the subjects from the study group and in 100% in the control group. The clinical and histological results of our study demonstrate that dental follicle stem cells are a valuable cell source for tissue engineering the periodontal tissue.

Keywords:
biomaterial for periodontal regeneration; dental follicle stem cells

Issue: 2018, Volume 69, Issue 7

Pages: 1785-1790

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6417

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUCACIU, O., CAMPIAN, R.S., SORITAU, O., BERCE, C., MESTER, A., APOSTU, D., TABARAN, F., MANOLE, M., BORDEA, R., IONEL, D.C., IONEL, A., Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study, Rev. Chim., 69(7), 2018, 1785-1790.

Vancouver
Lucaciu O, Campian RS, Soritau O, Berce C, Mester A, Apostu D, Tabaran F, Manole M, Bordea R, Ionel DC, Ionel A. Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study. Rev. Chim.[internet]. 2018 Jul;69(7):1785-1790. Available from: https://doi.org/10.37358/RC.18.7.6417

APA 6th edition
Lucaciu, O., Campian, R.S., Soritau, O., Berce, C., Mester, A., Apostu, D.,... Ionel, A. (2018). Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study. Revista de Chimie, 69(7), 1785-1790. https://doi.org/10.37358/RC.18.7.6417

Harvard
Lucaciu, O., Campian, R.S., Soritau, O., Berce, C., Mester, A., Apostu, D., Tabaran, F., Manole, M., Bordea, R., Ionel, D.C., Ionel, A. (2018). 'Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study', Revista de Chimie, 69(7), pp. 1785-1790. https://doi.org/10.37358/RC.18.7.6417

IEEE
O. Lucaciu, R.S. Campian, O. Soritau, C. Berce, A. Mester, D. Apostu, F. Tabaran, M. Manole, R. Bordea, D.C. Ionel, A. Ionel, "Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study". Revista de Chimie, vol. 69, no. 7, pp. 1785-1790, 2018. [online]. https://doi.org/10.37358/RC.18.7.6417

Text
Ondine Lucaciu, Radu Septimiu Campian, Olga Soritau, Cristian Berce, Alexandru Mester, Dragos Apostu, Flaviu Tabaran, Marius Manole, Roxana Bordea, Dan Cristian Ionel, Anca Ionel,
Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1785-1790,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6417.
(https://revistadechimie.ro/Articles.asp?ID=6417)
Keywords: biomaterial for periodontal regeneration; dental follicle stem cells

RIS
TY - JOUR
T1 - Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study
A1 - Lucaciu, Ondine
A2 - Campian, Radu Septimiu
A3 - Soritau, Olga
A4 - Berce, Cristian
A5 - Mester, Alexandru
A6 - Apostu, Dragos
A7 - Tabaran, Flaviu
A8 - Manole, Marius
A9 - Bordea, Roxana
A10 - Ionel, Dan Cristian
A11 - Ionel, Anca
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1785
EP - 1790
UR - https://doi.org/10.37358/RC.18.7.6417
KW - biomaterial for periodontal regeneration; dental follicle stem cells
ER -

BibTex
@article{RevCh2018P1785,
author = {Lucaciu Ondine and Campian Radu Septimiu and Soritau Olga and Berce Cristian and Mester Alexandru and Apostu Dragos and Tabaran Flaviu and Manole Marius and Bordea Roxana and Ionel Dan Cristian and Ionel Anca},
title = {Dental Follicle Stem Cells as a Biomaterial for Periodontal Regeneration A proof-of-concept study},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1785-1790},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6417},
url = {https://revistadechimie.ro/Articles.asp?ID=6417}
}

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