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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 7, 1838-1841

https://doi.org/10.37358/RC.18.7.6427

Hajnal Kelemen, Angella Csillag, Bela Noszal, Gabor Orgovan

NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins

Abstract:

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK[3). The least stable inclusion complex is formed with b-cyclodextrin, while the ezetimibe-methylated-b--cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.
Keywords:
ezetimibe; cyclodextrin; inclusion complex; Job plot; stoichiometry

Issue: 2018, Volume 69, Issue 7
Pages: 1838-1841
Publication date: 2018/8/15
https://doi.org/10.37358/RC.18.7.6427
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
KELEMEN, H., CSILLAG, A., NOSZAL, B., ORGOVAN, G., NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins, Rev. Chim., 69(7), 2018, 1838-1841.

Vancouver
Kelemen H, Csillag A, Noszal B, Orgovan G. NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins. Rev. Chim.[internet]. 2018 Jul;69(7):1838-1841. Available from: https://doi.org/10.37358/RC.18.7.6427


APA 6th edition
Kelemen, H., Csillag, A., Noszal, B. & Orgovan, G. (2018). NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins. Revista de Chimie, 69(7), 1838-1841. https://doi.org/10.37358/RC.18.7.6427


Harvard
Kelemen, H., Csillag, A., Noszal, B., Orgovan, G. (2018). 'NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins', Revista de Chimie, 69(7), pp. 1838-1841. https://doi.org/10.37358/RC.18.7.6427


IEEE
H. Kelemen, A. Csillag, B. Noszal, G. Orgovan, "NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins". Revista de Chimie, vol. 69, no. 7, pp. 1838-1841, 2018. [online]. https://doi.org/10.37358/RC.18.7.6427


Text
Hajnal Kelemen, Angella Csillag, Bela Noszal, Gabor Orgovan,
NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1838-1841,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6427.
(https://revistadechimie.ro/Articles.asp?ID=6427)
Keywords: ezetimibe; cyclodextrin; inclusion complex; Job plot; stoichiometry


RIS
TY - JOUR
T1 - NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins
A1 - Kelemen, Hajnal
A2 - Csillag, Angella
A3 - Noszal, Bela
A4 - Orgovan, Gabor
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1838
EP - 1841
UR - https://doi.org/10.37358/RC.18.7.6427
KW - ezetimibe
KW - cyclodextrin
KW - inclusion complex
KW - Job plot
KW - stoichiometry
ER -


BibTex
@article{RevCh2018P1838,
author = {Kelemen Hajnal and Csillag Angella and Noszal Bela and Orgovan Gabor},
title = {NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1838-1841},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6427},
url = {https://revistadechimie.ro/Articles.asp?ID=6427}
}
 
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