Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity<br>

Ienascu, Ioana Maria Carmen; Balaes, Tiberius; Petre, Cristiana Virginia; Pop, Raluca Oana; Cata, Adina; Stefanut, Mariana Nela; Albu, Paul; Poenaru, Marioara

Ioana Maria Carmen Ienascu, Tiberius Balaes, Cristiana Virginia Petre, Raluca Oana Pop, Adina Cata, Mariana Nela Stefanut, Paul Albu, Marioara Poenaru

Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity

Abstract:

In order to increase the biological activity, some novel molecules, esters, hydrazides, hydrazones of N-(2-bromo-phenyl)-2-hydroxy-benzamide, were obtained in good yields (86-93%), working at 150 °C, 500 W, 7-11 min, under microwave irradiation. All synthesized compounds were characterized using modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR and elemental analysis). Eight dilutions in dimethyl sulfoxide of these derivatives were tested against two phyto-pathogenic fungi, Fusarium oxysporum, Sclerotinia sclerotiorum and one common yeast, Saccharomyces cerevisiae. The antifungal activity was assessed using disc diffusion method, both negative, pure DMSO, and positive control, nystatin, were used. S. cerevisiae was slightly more sensitive than filamentous fungi, the strongest inhibition, MIC=0.3125g/L, was observed for N-(2-bromo-phenyl)-2-hydroxy-benzamide and N-(2-bromo-phenyl)-2-(4-dimethylamino-benzylidene-hydrazinocarbonylmethoxy)-benzamide. The most active compounds against F. oxysporum and S. sclerotiorum were N-(2-bromo-phenyl)-2-hydroxy-benzamide (MIC= 0.625g/L), N-(2-bromo-phenyl)-2-hydrazinocarbonylmethoxy-benzamide (MIC=1.25g/L) and N-(2-bromo-phenyl)-2-(4-dimethylamino-benzylidene-hydrazinocarbonyl-methoxy)-benzamide (MIC=0.625g/L), N-(2-bromo-phenyl)-2-hydrazinocarbonyl-methoxy-benzamide (MIC=1.25g/L), respectively.

Keywords:
N-(2-bromo-phenyl)-2-hydroxy-benzamide fungicides; Fusarium oxysporum; Sclerotinia sclerotiorum; Microwave-assisted synthesis; MIC

Issue: 2018, Volume 69, Issue 7

Pages: 1876-1880

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6435

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IENASCU, I.M.C., BALAES, T., PETRE, C.V., POP, R.O., CATA, A., STEFANUT, M.N., ALBU, P., POENARU, M., Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
, Rev. Chim., 69(7), 2018, 1876-1880.

Vancouver
Ienascu IMC, Balaes T, Petre CV, Pop RO, Cata A, Stefanut MN, Albu P, Poenaru M. Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
. Rev. Chim.[internet]. 2018 Jul;69(7):1876-1880. Available from: https://doi.org/10.37358/RC.18.7.6435

APA 6th edition
Ienascu, I.M.C., Balaes, T., Petre, C.V., Pop, R.O., Cata, A., Stefanut, M.N., Albu, P. & Poenaru, M. (2018). Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
. Revista de Chimie, 69(7), 1876-1880. https://doi.org/10.37358/RC.18.7.6435

Harvard
Ienascu, I.M.C., Balaes, T., Petre, C.V., Pop, R.O., Cata, A., Stefanut, M.N., Albu, P., Poenaru, M. (2018). 'Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
', Revista de Chimie, 69(7), pp. 1876-1880. https://doi.org/10.37358/RC.18.7.6435

IEEE
I.M.C. Ienascu, T. Balaes, C.V. Petre, R.O. Pop, A. Cata, M.N. Stefanut, P. Albu, M. Poenaru, "Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
". Revista de Chimie, vol. 69, no. 7, pp. 1876-1880, 2018. [online]. https://doi.org/10.37358/RC.18.7.6435

Text
Ioana Maria Carmen Ienascu, Tiberius Balaes, Cristiana Virginia Petre, Raluca Oana Pop, Adina Cata, Mariana Nela Stefanut, Paul Albu, Marioara Poenaru,
Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1876-1880,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6435.
(https://revistadechimie.ro/Articles.asp?ID=6435)
Keywords: N-(2-bromo-phenyl)-2-hydroxy-benzamide fungicides; Fusarium oxysporum; Sclerotinia sclerotiorum; Microwave-assisted synthesis; MIC

RIS
TY - JOUR
T1 - Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity

A1 - Ienascu, Ioana Maria Carmen
A2 - Balaes, Tiberius
A3 - Petre, Cristiana Virginia
A4 - Pop, Raluca Oana
A5 - Cata, Adina
A6 - Stefanut, Mariana Nela
A7 - Albu, Paul
A8 - Poenaru, Marioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1876
EP - 1880
UR - https://doi.org/10.37358/RC.18.7.6435
KW - N-(2-bromo-phenyl)-2-hydroxy-benzamide fungicides
KW - Fusarium oxysporum
KW - Sclerotinia sclerotiorum
KW - Microwave-assisted synthesis
KW - MIC
ER -

BibTex
@article{RevCh2018P1876,
author = {Ienascu Ioana Maria Carmen and Balaes Tiberius and Petre Cristiana Virginia and Pop Raluca Oana and Cata Adina and Stefanut Mariana Nela and Albu Paul and Poenaru Marioara},
title = {Novel N-(2-bromo-phenyl)-2-hydroxy-benzamide Derivatives with Antifugal Activity
},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1876-1880},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6435},
url = {https://revistadechimie.ro/Articles.asp?ID=6435}
}

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