A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite

Stiolica, Adina Turcu; Bubulica, Maria Viorica; Nicolaescu, Oana Elena; Croitoru, Octavian; Popescu, Mariana; Manda, Valentin Costel; Simionescu, Andreea; Neamtu, Johny

Adina Turcu Stiolica, Maria Viorica Bubulica, Oana Elena Nicolaescu, Octavian Croitoru, Mariana Popescu, Valentin Costel Manda, Andreea Simionescu, Johny Neamtu

A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite

Abstract:

A design of experiment (DoE) approach is presented for the optimization of Alendronate-hydroxyapatite nanoparticles’ synthesis. The synthesis was performed using the chemical precipitation technique from calcium nitrate, diammonium hydrogen phosphate and alendronate. Synthesis temperature, reactant addition rate and ripening time were chosen as the most relevant experimental factors for our synthesis. Design of Experiments was used in order to measure these conclusive process parameters and their effect on controlling some final nanoparticles parameters, such us: alendronate incorporation efficiency (IncorporationEfficiency, %), hydroxyapatite crystallite size (Size_XRD, nm), hydroxyapatite particle size distribution (Size_DLS, Å). Our study found that better HA-AL incorporation efficiency and small nonoparticles can be obtained using the following chemical process parameters: reaction temperature 30oC or smaller, ripening time 108h and addition rate 0.1mol/min. The analysis of more than one nanoparticles characteristics was possible using DoE software, MODDE 9.1. Thus, hydroxyapatite-alendronate incorporation efficiency should be expected to increase with decreasing temperature below 300C, increasing the maturate time at least 108h, at an addition rate of 0.1mol/min, in an N2 atmosphere. The same conditions will ensure nanoparticles small size that would be more desirable for the application of implants.

Keywords:
Design of Experiment - DoE; MODDE; hydroxyapatite-alendronate nanoparticles

Issue: 2018, Volume 69, Issue 8

Pages: 1944-1948

Publication date: 2018/9/15

https://doi.org/10.37358/RC.18.8.6451

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STIOLICA, A.T., BUBULICA, M.V., NICOLAESCU, O.E., CROITORU, O., POPESCU, M., MANDA, V.C., SIMIONESCU, A., NEAMTU, J., A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite, Rev. Chim., 69(8), 2018, 1944-1948.

Vancouver
Stiolica AT, Bubulica MV, Nicolaescu OE, Croitoru O, Popescu M, Manda VC, Simionescu A, Neamtu J. A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite. Rev. Chim.[internet]. 2018 Aug;69(8):1944-1948. Available from: https://doi.org/10.37358/RC.18.8.6451

APA 6th edition
Stiolica, A.T., Bubulica, M.V., Nicolaescu, O.E., Croitoru, O., Popescu, M., Manda, V.C., Simionescu, A. & Neamtu, J. (2018). A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite. Revista de Chimie, 69(8), 1944-1948. https://doi.org/10.37358/RC.18.8.6451

Harvard
Stiolica, A.T., Bubulica, M.V., Nicolaescu, O.E., Croitoru, O., Popescu, M., Manda, V.C., Simionescu, A., Neamtu, J. (2018). 'A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite', Revista de Chimie, 69(8), pp. 1944-1948. https://doi.org/10.37358/RC.18.8.6451

IEEE
A.T. Stiolica, M.V. Bubulica, O.E. Nicolaescu, O. Croitoru, M. Popescu, V.C. Manda, A. Simionescu, J. Neamtu, "A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite". Revista de Chimie, vol. 69, no. 8, pp. 1944-1948, 2018. [online]. https://doi.org/10.37358/RC.18.8.6451

Text
Adina Turcu Stiolica, Maria Viorica Bubulica, Oana Elena Nicolaescu, Octavian Croitoru, Mariana Popescu, Valentin Costel Manda, Andreea Simionescu, Johny Neamtu,
A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 1944-1948,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6451.
(https://revistadechimie.ro/Articles.asp?ID=6451)
Keywords: Design of Experiment - DoE; MODDE; hydroxyapatite-alendronate nanoparticles

RIS
TY - JOUR
T1 - A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite
A1 - Stiolica, Adina Turcu
A2 - Bubulica, Maria Viorica
A3 - Nicolaescu, Oana Elena
A4 - Croitoru, Octavian
A5 - Popescu, Mariana
A6 - Manda, Valentin Costel
A7 - Simionescu, Andreea
A8 - Neamtu, Johny
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 1944
EP - 1948
UR - https://doi.org/10.37358/RC.18.8.6451
KW - Design of Experiment - DoE
KW - MODDE
KW - hydroxyapatite-alendronate nanoparticles
ER -

BibTex
@article{RevCh2018P1944,
author = {Stiolica Adina Turcu and Bubulica Maria Viorica and Nicolaescu Oana Elena and Croitoru Octavian and Popescu Mariana and Manda Valentin Costel and Simionescu Andreea and Neamtu Johny},
title = {A Design of Experiment Approach to the Synthesis of Alendronate-incorporated Hydroxyapatite},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {1944-1948},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6451},
url = {https://revistadechimie.ro/Articles.asp?ID=6451}
}

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