The Implications of E-cadherin Expression in Pancreatic Cancer

Trofin, Ana Maria; Lupascu, Cristian; Spiridon, Irene Cianga; Lupascu, Corina Ursulescu; Zabara, Mihai; Grigorean, Valentin; Brasoveanu, Vladislav

Ana Maria Trofin, Cristian Lupascu, Irene Cianga Spiridon, Corina Ursulescu Lupascu, Mihai Zabara, Valentin Grigorean, Vladislav Brasoveanu

The Implications of E-cadherin Expression in Pancreatic Cancer

Abstract:

Pancreatic cancer is an aggressive neoplasia and has a fatal prognosis, with approximately 85% of patients diagnosed in advanced stages of the disease. The purpose of this study was to determine if the loss of e-cadherin expression in pancreatic pancreatic is a predictor of the prognosis of this disease. This research is based on a retrospective study performed on a group of 81 patients who benefited from pancreatic resection in our Surgical Clinic, between January 2008 and December 2016 and assessing the positivity of e-cadherin. There were no correlations between e-cadherin expression and other clinic-pathological factors, including gender, age, tumor status, lymph node metastasis, microscopic vascular invasion, perineural invasion. Low-differentiated pancreatic cancer was more likely to exhibit e-cadherin expression loss than well-differentiated forms of cancer (p-0.07). The mean survival in e-cadherin positive patients (17.1 months) was significantly worse compared to those with E-cadherin absent (6.8 months).In conclusion, we found that partial loss of e-cadherin in primary pancreatic adenocarcinomas is an independent predictor of a negative outcome among patients with curative surgical resection of pancreatic lesions.

Keywords:
Pancreas; Adenocarcinoma; E-cadherin; Prognosis

Issue: 2018, Volume 69, Issue 8

Pages: 2291-2294

Publication date: 2018/9/15

https://doi.org/10.37358/RC.18.8.6518

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TROFIN, A.M., LUPASCU, C., SPIRIDON, I.C., LUPASCU, C.U., ZABARA, M., GRIGOREAN, V., BRASOVEANU, V., The Implications of E-cadherin Expression in Pancreatic Cancer, Rev. Chim., 69(8), 2018, 2291-2294.

Vancouver
Trofin AM, Lupascu C, Spiridon IC, Lupascu CU, Zabara M, Grigorean V, Brasoveanu V. The Implications of E-cadherin Expression in Pancreatic Cancer. Rev. Chim.[internet]. 2018 Aug;69(8):2291-2294. Available from: https://doi.org/10.37358/RC.18.8.6518

APA 6th edition
Trofin, A.M., Lupascu, C., Spiridon, I.C., Lupascu, C.U., Zabara, M., Grigorean, V. & Brasoveanu, V. (2018). The Implications of E-cadherin Expression in Pancreatic Cancer. Revista de Chimie, 69(8), 2291-2294. https://doi.org/10.37358/RC.18.8.6518

Harvard
Trofin, A.M., Lupascu, C., Spiridon, I.C., Lupascu, C.U., Zabara, M., Grigorean, V., Brasoveanu, V. (2018). 'The Implications of E-cadherin Expression in Pancreatic Cancer', Revista de Chimie, 69(8), pp. 2291-2294. https://doi.org/10.37358/RC.18.8.6518

IEEE
A.M. Trofin, C. Lupascu, I.C. Spiridon, C.U. Lupascu, M. Zabara, V. Grigorean, V. Brasoveanu, "The Implications of E-cadherin Expression in Pancreatic Cancer". Revista de Chimie, vol. 69, no. 8, pp. 2291-2294, 2018. [online]. https://doi.org/10.37358/RC.18.8.6518

Text
Ana Maria Trofin, Cristian Lupascu, Irene Cianga Spiridon, Corina Ursulescu Lupascu, Mihai Zabara, Valentin Grigorean, Vladislav Brasoveanu,
The Implications of E-cadherin Expression in Pancreatic Cancer,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2291-2294,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6518.
(https://revistadechimie.ro/Articles.asp?ID=6518)
Keywords: Pancreas; Adenocarcinoma; E-cadherin; Prognosis

RIS
TY - JOUR
T1 - The Implications of E-cadherin Expression in Pancreatic Cancer
A1 - Trofin, Ana Maria
A2 - Lupascu, Cristian
A3 - Spiridon, Irene Cianga
A4 - Lupascu, Corina Ursulescu
A5 - Zabara, Mihai
A6 - Grigorean, Valentin
A7 - Brasoveanu, Vladislav
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2291
EP - 2294
UR - https://doi.org/10.37358/RC.18.8.6518
KW - Pancreas
KW - Adenocarcinoma
KW - E-cadherin; Prognosis
ER -

BibTex
@article{RevCh2018P2291,
author = {Trofin Ana Maria and Lupascu Cristian and Spiridon Irene Cianga and Lupascu Corina Ursulescu and Zabara Mihai and Grigorean Valentin and Brasoveanu Vladislav},
title = {The Implications of E-cadherin Expression in Pancreatic Cancer},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2291-2294},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6518},
url = {https://revistadechimie.ro/Articles.asp?ID=6518}
}

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