Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss

Erdelean, Dragos; Farcas, Simona Sorina; Poroch, Vladimir; Andreescu, Nicoleta Ioana; Erdelean, Izabella; Dobrescu, Andreea Iulia; Nussbaum, Laura Alexandra; Hogea, Lavinia Maria; Navolan, Dan; Tutac, Paul; Puiu, Maria

Dragos Erdelean, Simona Sorina Farcas, Vladimir Poroch, Nicoleta Ioana Andreescu, Izabella Erdelean, Andreea Iulia Dobrescu, Laura Alexandra Nussbaum, Lavinia Maria Hogea, Dan Navolan, Paul Tutac, Maria Puiu

Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss

Abstract:

Spontaneous miscarriage is reported in approximately 15% of the clinically recognized pregnancies. Several reports have showed an increased risk of miscarriage in patients with thrombophilia, but due to the heterogeneity of study design the role thrombophilic factors and the use of anticoagulant therapy in prevention of pregnancy loss is still unclear. The current study includes 55 patients for which we ran a screening of the most commonly inherited thrombophilia mutations (FVL, FII, MTHFR C677T/A1298, PAI 4G/5G mutations). We found that most of the patients (92.72%) associated mutation in at least 2 of the genes evaluated. Only a small number of patients (7.27%) had a single variant identified. We have found high prevalence of the studied variants in the pregnant patients that experience pregnancy loss, with risk allele frequencies increased from 2 to 11 times as compared to the general population. We consider that evaluation of the trombophilic variants should be indicated for patients with pregnancy loss in order to establish a possible cause for the miscarriage.

Keywords:
pregnancy; thrombophilia; chromosomal abnormalities; miscarriage; karyotype

Issue: 2018, Volume 69, Issue 11

Pages: 3122-3125

Publication date: 2018/12/15

https://doi.org/10.37358/RC.18.11.6696

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ERDELEAN, D., FARCAS, S.S., POROCH, V., ANDREESCU, N.I., ERDELEAN, I., DOBRESCU, A.I., NUSSBAUM, L.A., HOGEA, L.M., NAVOLAN, D., TUTAC, P., PUIU, M., Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss, Rev. Chim., 69(11), 2018, 3122-3125.

Vancouver
Erdelean D, Farcas SS, Poroch V, Andreescu NI, Erdelean I, Dobrescu AI, Nussbaum LA, Hogea LM, Navolan D, Tutac P, Puiu M. Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss. Rev. Chim.[internet]. 2018 Nov;69(11):3122-3125. Available from: https://doi.org/10.37358/RC.18.11.6696

APA 6th edition
Erdelean, D., Farcas, S.S., Poroch, V., Andreescu, N.I., Erdelean, I., Dobrescu, A.I.,... Puiu, M. (2018). Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss. Revista de Chimie, 69(11), 3122-3125. https://doi.org/10.37358/RC.18.11.6696

Harvard
Erdelean, D., Farcas, S.S., Poroch, V., Andreescu, N.I., Erdelean, I., Dobrescu, A.I., Nussbaum, L.A., Hogea, L.M., Navolan, D., Tutac, P., Puiu, M. (2018). 'Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss', Revista de Chimie, 69(11), pp. 3122-3125. https://doi.org/10.37358/RC.18.11.6696

IEEE
D. Erdelean, S.S. Farcas, V. Poroch, N.I. Andreescu, I. Erdelean, A.I. Dobrescu, L.A. Nussbaum, L.M. Hogea, D. Navolan, P. Tutac, M. Puiu, "Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss". Revista de Chimie, vol. 69, no. 11, pp. 3122-3125, 2018. [online]. https://doi.org/10.37358/RC.18.11.6696

Text
Dragos Erdelean, Simona Sorina Farcas, Vladimir Poroch, Nicoleta Ioana Andreescu, Izabella Erdelean, Andreea Iulia Dobrescu, Laura Alexandra Nussbaum, Lavinia Maria Hogea, Dan Navolan, Paul Tutac, Maria Puiu,
Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss,
Revista de Chimie,
Volume 69, Issue 11,
2018,
Pages 3122-3125,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.11.6696.
(https://revistadechimie.ro/Articles.asp?ID=6696)
Keywords: pregnancy; thrombophilia; chromosomal abnormalities; miscarriage; karyotype

RIS
TY - JOUR
T1 - Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss
A1 - Erdelean, Dragos
A2 - Farcas, Simona Sorina
A3 - Poroch, Vladimir
A4 - Andreescu, Nicoleta Ioana
A5 - Erdelean, Izabella
A6 - Dobrescu, Andreea Iulia
A7 - Nussbaum, Laura Alexandra
A8 - Hogea, Lavinia Maria
A9 - Navolan, Dan
A10 - Tutac, Paul
A11 - Puiu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 11
SP - 3122
EP - 3125
UR - https://doi.org/10.37358/RC.18.11.6696
KW - pregnancy
KW - thrombophilia
KW - chromosomal abnormalities
KW - miscarriage
KW - karyotype
ER -

BibTex
@article{RevCh2018P3122,
author = {Erdelean Dragos and Farcas Simona Sorina and Poroch Vladimir and Andreescu Nicoleta Ioana and Erdelean Izabella and Dobrescu Andreea Iulia and Nussbaum Laura Alexandra and Hogea Lavinia Maria and Navolan Dan and Tutac Paul and Puiu Maria},
title = {Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss},
journal = {Revista de Chimie},
volume = {69},
number = {11},
pages = {3122-3125},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.11.6696},
url = {https://revistadechimie.ro/Articles.asp?ID=6696}
}

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