The Biochemical Biomarkers Determination in  Alzheimer  Dementia

Birlutiu, Victoria; Stef, Laura; Mitariu, Sebastian Ioan Cernusca; Filip, Corina Roman; Duica, Lavinia; Antonescu, Elisabeta; Pirlog, Mihail; Purnichi, Traian; Silisteanu, Sinziana Calina; Manea, Marinela Minodora

Victoria Birlutiu, Laura Stef, Sebastian Ioan Cernusca Mitariu, Corina Roman Filip, Lavinia Duica, Elisabeta Antonescu, Mihail Pirlog, Traian Purnichi, Sinziana Calina Silisteanu, Marinela Minodora Manea

The Biochemical Biomarkers Determination in Alzheimer Dementia

Abstract:

Alzheimer’s disease (AD) is a complex neuropsychiatric condition characterized by progressive cognitive symptoms.The social and psychological costs associated with the care of AD patients are very high; therefore, significant funds for research in this field are being invested worldwide. The accuracy of medical methods for establishing the diagnosis of AD with specific neuropathology is very important. Biomarkers can detect AD in their pre-clinical stage, monitor the disease progression, and detectmore objectively the treatment response. We performed a retrospective study of 100 patients admitted to the Gheorghe Preda Psychiatric Hospital of Sibiu with the diagnosis of Mild Cognitive Impairment and Alzheimer’s Dementia. The diagnosis was established according to the Diagnostic and Statistical Manual Disorders-4th edition criteria and the severity of the condition was determined by the Mini Mental State Examination. Our retrospective study revealed that in a certain period of time, most hospitalized patients with AD had the most days of hospitalization; they were patients in severe stage, due to the needs of multidisciplinary care and the multiple possibilities offered by medical staff. At present, AD research, in addition to finding therapeutic remedies in the clinical stages of AD, also aims at primary and secondary prevention strategies, including the detection of biomarkers in the pre-clinical stage of AD.

Keywords:
Alzheimer’s disease; diagnosis; amyloidplaques; protein

Issue: 2018, Volume 69, Issue 11

Pages: 3155-3159

Publication date: 2018/12/15

https://doi.org/10.37358/RC.18.11.6702

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BIRLUTIU, V., STEF, L., MITARIU, S.I.C., FILIP, C.R., DUICA, L., ANTONESCU, E., PIRLOG, M., PURNICHI, T., SILISTEANU, S.C., MANEA, M.M., The Biochemical Biomarkers Determination in Alzheimer Dementia, Rev. Chim., 69(11), 2018, 3155-3159.

Vancouver
Birlutiu V, Stef L, Mitariu SIC, Filip CR, Duica L, Antonescu E, Pirlog M, Purnichi T, Silisteanu SC, Manea MM. The Biochemical Biomarkers Determination in Alzheimer Dementia. Rev. Chim.[internet]. 2018 Nov;69(11):3155-3159. Available from: https://doi.org/10.37358/RC.18.11.6702

APA 6th edition
Birlutiu, V., Stef, L., Mitariu, S.I.C., Filip, C.R., Duica, L., Antonescu, E.,... Manea, M.M. (2018). The Biochemical Biomarkers Determination in Alzheimer Dementia. Revista de Chimie, 69(11), 3155-3159. https://doi.org/10.37358/RC.18.11.6702

Harvard
Birlutiu, V., Stef, L., Mitariu, S.I.C., Filip, C.R., Duica, L., Antonescu, E., Pirlog, M., Purnichi, T., Silisteanu, S.C., Manea, M.M. (2018). 'The Biochemical Biomarkers Determination in Alzheimer Dementia', Revista de Chimie, 69(11), pp. 3155-3159. https://doi.org/10.37358/RC.18.11.6702

IEEE
V. Birlutiu, L. Stef, S.I.C. Mitariu, C.R. Filip, L. Duica, E. Antonescu, M. Pirlog, T. Purnichi, S.C. Silisteanu, M.M. Manea, "The Biochemical Biomarkers Determination in Alzheimer Dementia". Revista de Chimie, vol. 69, no. 11, pp. 3155-3159, 2018. [online]. https://doi.org/10.37358/RC.18.11.6702

Text
Victoria Birlutiu, Laura Stef, Sebastian Ioan Cernusca Mitariu, Corina Roman Filip, Lavinia Duica, Elisabeta Antonescu, Mihail Pirlog, Traian Purnichi, Sinziana Calina Silisteanu, Marinela Minodora Manea,
The Biochemical Biomarkers Determination in Alzheimer Dementia,
Revista de Chimie,
Volume 69, Issue 11,
2018,
Pages 3155-3159,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.11.6702.
(https://revistadechimie.ro/Articles.asp?ID=6702)
Keywords: Alzheimer’s disease; diagnosis; amyloidplaques; protein

RIS
TY - JOUR
T1 - The Biochemical Biomarkers Determination in Alzheimer Dementia
A1 - Birlutiu, Victoria
A2 - Stef, Laura
A3 - Mitariu, Sebastian Ioan Cernusca
A4 - Filip, Corina Roman
A5 - Duica, Lavinia
A6 - Antonescu, Elisabeta
A7 - Pirlog, Mihail
A8 - Purnichi, Traian
A9 - Silisteanu, Sinziana Calina
A10 - Manea, Marinela Minodora
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 11
SP - 3155
EP - 3159
UR - https://doi.org/10.37358/RC.18.11.6702
KW - Alzheimer’s disease
KW - diagnosis
KW - amyloidplaques
KW - protein
ER -

BibTex
@article{RevCh2018P3155,
author = {Birlutiu Victoria and Stef Laura and Mitariu Sebastian Ioan Cernusca and Filip Corina Roman and Duica Lavinia and Antonescu Elisabeta and Pirlog Mihail and Purnichi Traian and Silisteanu Sinziana Calina and Manea Marinela Minodora},
title = {The Biochemical Biomarkers Determination in Alzheimer Dementia},
journal = {Revista de Chimie},
volume = {69},
number = {11},
pages = {3155-3159},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.11.6702},
url = {https://revistadechimie.ro/Articles.asp?ID=6702}
}

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