The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4

Susan, Razvan; Corlan, Ion Virgil; Vaduva, Delia Berceanu; Popovici, Ramona; Radulescu, Matilda; Susan, Monica; Faur, Alin; Cheveresan, Adelina

Razvan Susan, Ion Virgil Corlan, Delia Berceanu Vaduva, Ramona Popovici, Matilda Radulescu, Monica Susan, Alin Faur, Adelina Cheveresan

The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4

Abstract:

This present study aimed to assess the influence of different chemical compounds which are commonly found in the composition of products used for oral hygiene on primary gingival keratinocyte, human gingival fibroblast and tongue squamous cell carcinoma behaviour. Chlorhexidine (Chx), aspartame (Asp), xylitol (Xyl) and sodium bicarbonate (NaB) were evaluated in an in vitroresearch regarding cells morphology and cytotoxicity. Primary gingival keratinocytes (PGK)and fibroblasts (HGF)treated with different concentration of the tested compounds did not show significant changes, nor related to morphology nor related to viability at the lowest concentrations used ([ 25µM). In contrast, the tumor cells were affected by the test compounds, especially xylitol and sodium bicarbonate, both in terms of morphology and cytotoxicity, at concentrations over 5µM.

Keywords:
chlorhexidine; aspartame; xylitol; sodium bicarbonate; oral cells

Issue: 2018, Volume 69, Issue 11

Pages: 3160-3163

Publication date: 2018/12/15

https://doi.org/10.37358/RC.18.11.6703

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SUSAN, R., CORLAN, I.V., VADUVA, D.B., POPOVICI, R., RADULESCU, M., SUSAN, M., FAUR, A., CHEVERESAN, A., The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4, Rev. Chim., 69(11), 2018, 3160-3163.

Vancouver
Susan R, Corlan IV, Vaduva DB, Popovici R, Radulescu M, Susan M, Faur A, Cheveresan A. The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4. Rev. Chim.[internet]. 2018 Nov;69(11):3160-3163. Available from: https://doi.org/10.37358/RC.18.11.6703

APA 6th edition
Susan, R., Corlan, I.V., Vaduva, D.B., Popovici, R., Radulescu, M., Susan, M., Faur, A. & Cheveresan, A. (2018). The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4. Revista de Chimie, 69(11), 3160-3163. https://doi.org/10.37358/RC.18.11.6703

Harvard
Susan, R., Corlan, I.V., Vaduva, D.B., Popovici, R., Radulescu, M., Susan, M., Faur, A., Cheveresan, A. (2018). 'The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4', Revista de Chimie, 69(11), pp. 3160-3163. https://doi.org/10.37358/RC.18.11.6703

IEEE
R. Susan, I.V. Corlan, D.B. Vaduva, R. Popovici, M. Radulescu, M. Susan, A. Faur, A. Cheveresan, "The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4". Revista de Chimie, vol. 69, no. 11, pp. 3160-3163, 2018. [online]. https://doi.org/10.37358/RC.18.11.6703

Text
Razvan Susan, Ion Virgil Corlan, Delia Berceanu Vaduva, Ramona Popovici, Matilda Radulescu, Monica Susan, Alin Faur, Adelina Cheveresan,
The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4,
Revista de Chimie,
Volume 69, Issue 11,
2018,
Pages 3160-3163,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.11.6703.
(https://revistadechimie.ro/Articles.asp?ID=6703)
Keywords: chlorhexidine; aspartame; xylitol; sodium bicarbonate; oral cells

RIS
TY - JOUR
T1 - The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4
A1 - Susan, Razvan
A2 - Corlan, Ion Virgil
A3 - Vaduva, Delia Berceanu
A4 - Popovici, Ramona
A5 - Radulescu, Matilda
A6 - Susan, Monica
A7 - Faur, Alin
A8 - Cheveresan, Adelina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 11
SP - 3160
EP - 3163
UR - https://doi.org/10.37358/RC.18.11.6703
KW - chlorhexidine
KW - aspartame
KW - xylitol
KW - sodium bicarbonate
KW - oral cells
ER -

BibTex
@article{RevCh2018P3160,
author = {Susan Razvan and Corlan Ion Virgil and Vaduva Delia Berceanu and Popovici Ramona and Radulescu Matilda and Susan Monica and Faur Alin and Cheveresan Adelina},
title = {The Influence of Some Synthesis Compounds on Healthy and Tumoral Oral Cell Lines: PGK, HGF and SCC4},
journal = {Revista de Chimie},
volume = {69},
number = {11},
pages = {3160-3163},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.11.6703},
url = {https://revistadechimie.ro/Articles.asp?ID=6703}
}

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