Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies

Sakthikumar, Karunganathan; Sankarganesh, Murugesan; Raja, Jeyaraj Dhaveethu; Mitu, Liviu

Karunganathan Sakthikumar, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Liviu Mitu

Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies

Abstract:

A new series of water soluble mixed ligand complexes [MII(L)(bpy)AcO].nH2O M = Cu, (n=1) (1); Co (2), Mn (3), Ni (4) (n=4) and Zn (5) (n=2) have been synthesized from 2-(2-Morpholinoethylimino)methyl)phenol Schiff base ligand (HL) and 2,2¹-bipyridine in a 1:1:1 molar ratio. The resulting complexes were characterized by spectral techniques. The spectral data of these complexes suggest an octahedral geometry. In vitro antioxidant activity results of DPPH assay, hydroxyl radical, super oxide and nitric oxide for complexes (1-5) were compared with ligand (HL) and in vitro antimicrobial activities of all compounds were examined against selected bacterial and fungal strains which indicate that the complexes exhibit higher antimicrobial activity than free ligand (HL). Gel electrophoresis results indicated that, complexes (1) and (2) have exhibited more DNA cleavage efficiency than others. The intrinsic binding constant (Kb) values for the complexes (1-5) observed by electronic absorption technique were in the order of (1) ] (4) ] (5) ] (2) ] (3) and DNA binding affinity values for these complexes obtained by viscosity measurements were in the order of ethidium bromide ] (1) ] (2) ] (3) ] (4) ] (5).

Keywords:
Schiff base; bipyridine; octahedral; DNA interactions

Issue: 2018, Volume 69, Issue 11

Pages: 3169-3177

Publication date: 2018/12/15

https://doi.org/10.37358/RC.18.11.6705

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SAKTHIKUMAR, K., SANKARGANESH, M., RAJA, J.D., MITU, L., Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies, Rev. Chim., 69(11), 2018, 3169-3177.

Vancouver
Sakthikumar K, Sankarganesh M, Raja JD, Mitu L. Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies. Rev. Chim.[internet]. 2018 Nov;69(11):3169-3177. Available from: https://doi.org/10.37358/RC.18.11.6705

APA 6th edition
Sakthikumar, K., Sankarganesh, M., Raja, J.D. & Mitu, L. (2018). Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies. Revista de Chimie, 69(11), 3169-3177. https://doi.org/10.37358/RC.18.11.6705

Harvard
Sakthikumar, K., Sankarganesh, M., Raja, J.D., Mitu, L. (2018). 'Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies', Revista de Chimie, 69(11), pp. 3169-3177. https://doi.org/10.37358/RC.18.11.6705

IEEE
K. Sakthikumar, M. Sankarganesh, J.D. Raja, L. Mitu, "Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies". Revista de Chimie, vol. 69, no. 11, pp. 3169-3177, 2018. [online]. https://doi.org/10.37358/RC.18.11.6705

Text
Karunganathan Sakthikumar, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Liviu Mitu,
Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies,
Revista de Chimie,
Volume 69, Issue 11,
2018,
Pages 3169-3177,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.11.6705.
(https://revistadechimie.ro/Articles.asp?ID=6705)
Keywords: Schiff base; bipyridine; octahedral; DNA interactions

RIS
TY - JOUR
T1 - Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies
A1 - Sakthikumar, Karunganathan
A2 - Sankarganesh, Murugesan
A3 - Raja, Jeyaraj Dhaveethu
A4 - Mitu, Liviu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 11
SP - 3169
EP - 3177
UR - https://doi.org/10.37358/RC.18.11.6705
KW - Schiff base
KW - bipyridine
KW - octahedral
KW - DNA interactions
ER -

BibTex
@article{RevCh2018P3169,
author = {Sakthikumar Karunganathan and Sankarganesh Murugesan and Raja Jeyaraj Dhaveethu and Mitu Liviu},
title = {Water Soluble Mixed Ligand Complexes Spectral, antioxidant, antimicrobial and DNA interaction studies},
journal = {Revista de Chimie},
volume = {69},
number = {11},
pages = {3169-3177},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.11.6705},
url = {https://revistadechimie.ro/Articles.asp?ID=6705}
}

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