Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level

Chiriac, Florentina Laura; Paun, Iuliana; Pirvu, Florinela; Cruceru, Liliana; Pascu, Luoana Florentina; Galaon, Toma

Florentina Laura Chiriac, Iuliana Paun, Florinela Pirvu, Liliana Cruceru, Luoana Florentina Pascu, Toma Galaon

Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level

Abstract:

The presence of acrylamide, a potential human carcinogen, in treated drinking water has been a long-time concern for public health agencies. Due to this, acrylamide is included among the substances to be monitored in drinking water with a stated maximum admissible level of 0.1 µg/L in Europe. The necessity for ultra-trace level detection of acrylamide has led to development of an Offline-SPE-LC-MS method that involves SPE extraction of acrylamide using a strong adsorbent like activated charcoal followed by concentration. Simultaneously, a simple and rapid large volume Direct Injection LC-MS method was optimized from the previous method to detect acrylamide without the resource and time-consuming SPE step. A comprehensive comparison between the efficiency and sensitivity of the two methods is made. Optimization of LC-MS parameters (column temperature, mobile phase composition and flow, collision energy, fragmentor voltage, capillary voltage or MRM transitions) allowed high detection sensitivity. Due to Acrylamide high polarity, a Synergi Fusion-RP column with amide polar embedded groups was chosen to achieve reasonable retention and peak shape for acrylamide with a short run-time of only 3 min. The two methods provided excellent sensitivity, with reasonably low LOQ values of 2 ng/L for the Offline-SPE-LC-MS method and 30 ng/L for the Direct Injection LC-MS method. Intra-day and inter-day precision (RSD%) were 7.3 and 10.3%, for the Offline-SPE-LC-MS method and 2.4% and 6.2%, respectively for the Direct Injection LC-MS method. The analysis of acrylamide was successfully performed in drinking water from different location consumers and water treatment plants in Romania. Acrylamide was found in drinking water samples with levels between 5.2 and 35.7 ng/L using the Offline-SPE-LC-MS method. The direct injection method can only be used for acrylamide levels higher than its LOQ value (30 ng/L).

Keywords:
acrylamide; offline-SPE-LC-MS; direct injection LC-MS; drinking water

Issue: 2018, Volume 69, Issue 11

Pages: 3229-3233

Publication date: 2018/12/15

https://doi.org/10.37358/RC.18.11.6719

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CHIRIAC, F.L., PAUN, I., PIRVU, F., CRUCERU, L., PASCU, L.F., GALAON, T., Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level, Rev. Chim., 69(11), 2018, 3229-3233.

Vancouver
Chiriac FL, Paun I, Pirvu F, Cruceru L, Pascu LF, Galaon T. Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level. Rev. Chim.[internet]. 2018 Nov;69(11):3229-3233. Available from: https://doi.org/10.37358/RC.18.11.6719

APA 6th edition
Chiriac, F.L., Paun, I., Pirvu, F., Cruceru, L., Pascu, L.F. & Galaon, T. (2018). Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level. Revista de Chimie, 69(11), 3229-3233. https://doi.org/10.37358/RC.18.11.6719

Harvard
Chiriac, F.L., Paun, I., Pirvu, F., Cruceru, L., Pascu, L.F., Galaon, T. (2018). 'Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level', Revista de Chimie, 69(11), pp. 3229-3233. https://doi.org/10.37358/RC.18.11.6719

IEEE
F.L. Chiriac, I. Paun, F. Pirvu, L. Cruceru, L.F. Pascu, T. Galaon, "Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level". Revista de Chimie, vol. 69, no. 11, pp. 3229-3233, 2018. [online]. https://doi.org/10.37358/RC.18.11.6719

Text
Florentina Laura Chiriac, Iuliana Paun, Florinela Pirvu, Liliana Cruceru, Luoana Florentina Pascu, Toma Galaon,
Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level,
Revista de Chimie,
Volume 69, Issue 11,
2018,
Pages 3229-3233,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.11.6719.
(https://revistadechimie.ro/Articles.asp?ID=6719)
Keywords: acrylamide; offline-SPE-LC-MS; direct injection LC-MS; drinking water

RIS
TY - JOUR
T1 - Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level
A1 - Chiriac, Florentina Laura
A2 - Paun, Iuliana
A3 - Pirvu, Florinela
A4 - Cruceru, Liliana
A5 - Pascu, Luoana Florentina
A6 - Galaon, Toma
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 11
SP - 3229
EP - 3233
UR - https://doi.org/10.37358/RC.18.11.6719
KW - acrylamide
KW - offline-SPE-LC-MS
KW - direct injection LC-MS
KW - drinking water
ER -

BibTex
@article{RevCh2018P3229,
author = {Chiriac Florentina Laura and Paun Iuliana and Pirvu Florinela and Cruceru Liliana and Pascu Luoana Florentina and Galaon Toma},
title = {Parallel between Offline-SPE-LC-MS and Direct Injection LC-MS Methods for Acrylamide Detection in Drinking Water at Parts Per Trillion Level},
journal = {Revista de Chimie},
volume = {69},
number = {11},
pages = {3229-3233},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.11.6719},
url = {https://revistadechimie.ro/Articles.asp?ID=6719}
}

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