Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products

Serban, Ecaterina Anca; Diaconu, Ioana; Ruse, Elena; Batrinescu, Gheorghe; Nechifor, Gheorghe; Lazar, Mihai Nita

Ecaterina Anca Serban, Ioana Diaconu, Elena Ruse, Gheorghe Batrinescu, Gheorghe Nechifor, Mihai Nita Lazar

Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products

Abstract:

In this present paper the behavior of two important pharmaceutical compounds, namely: nicotinic acid (vitamin PP/B3) and para-aminobenzoic acid (vitamin B10) to the transport through a liquid membrane of chloroform containing Aliquat 336 have been studied. The influence of operational parameters such as: solute concentration in the feed phase, stripping agent concentration in the stripping phase, transport time was monitored. The assessment of the obtained results allowed establishing of optimal transport conditions as well as identification of a kinetic transport model for nicotinic acid corresponding to consecutive irreversible 1st order reactions. The maximum transport efficiency was 96% and it was obtained at a concentration of 10-4 mol/L nicotinic acid in the feed phase and a concentration of 1 mol/L sodium hydroxide in the stripping phase. The transport time necessary to achieve this efficiency was 6 h. The results obtained led to important conclusions regarding the possibility of separating these two compounds. Analytical control of the process was done spectrophotometrically. The maximum absorbance was obtained at their characteristic wavelengths, namely 262 nm for nicotinic acid and respectively 267 nm for para-aminobenzoic acid.

Keywords:
nicotinic acid; para-aminobenzoic acid; bulk liquid membrane transport; separation of pharmaceutical products

Issue: 2018, Volume 69, Issue 11

Pages: 3257-3260

Publication date: 2018/12/15

https://doi.org/10.37358/RC.18.11.6725

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SERBAN, E.A., DIACONU, I., RUSE, E., BATRINESCU, G., NECHIFOR, G., LAZAR, M.N., Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products, Rev. Chim., 69(11), 2018, 3257-3260.

Vancouver
Serban EA, Diaconu I, Ruse E, Batrinescu G, Nechifor G, Lazar MN. Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products. Rev. Chim.[internet]. 2018 Nov;69(11):3257-3260. Available from: https://doi.org/10.37358/RC.18.11.6725

APA 6th edition
Serban, E.A., Diaconu, I., Ruse, E., Batrinescu, G., Nechifor, G. & Lazar, M.N. (2018). Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products. Revista de Chimie, 69(11), 3257-3260. https://doi.org/10.37358/RC.18.11.6725

Harvard
Serban, E.A., Diaconu, I., Ruse, E., Batrinescu, G., Nechifor, G., Lazar, M.N. (2018). 'Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products', Revista de Chimie, 69(11), pp. 3257-3260. https://doi.org/10.37358/RC.18.11.6725

IEEE
E.A. Serban, I. Diaconu, E. Ruse, G. Batrinescu, G. Nechifor, M.N. Lazar, "Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products". Revista de Chimie, vol. 69, no. 11, pp. 3257-3260, 2018. [online]. https://doi.org/10.37358/RC.18.11.6725

Text
Ecaterina Anca Serban, Ioana Diaconu, Elena Ruse, Gheorghe Batrinescu, Gheorghe Nechifor, Mihai Nita Lazar,
Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products,
Revista de Chimie,
Volume 69, Issue 11,
2018,
Pages 3257-3260,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.11.6725.
(https://revistadechimie.ro/Articles.asp?ID=6725)
Keywords: nicotinic acid; para-aminobenzoic acid; bulk liquid membrane transport; separation of pharmaceutical products

RIS
TY - JOUR
T1 - Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products
A1 - Serban, Ecaterina Anca
A2 - Diaconu, Ioana
A3 - Ruse, Elena
A4 - Batrinescu, Gheorghe
A5 - Nechifor, Gheorghe
A6 - Lazar, Mihai Nita
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 11
SP - 3257
EP - 3260
UR - https://doi.org/10.37358/RC.18.11.6725
KW - nicotinic acid
KW - para-aminobenzoic acid
KW - bulk liquid membrane transport
KW - separation of pharmaceutical products
ER -

BibTex
@article{RevCh2018P3257,
author = {Serban Ecaterina Anca and Diaconu Ioana and Ruse Elena and Batrinescu Gheorghe and Nechifor Gheorghe and Lazar Mihai Nita},
title = {Bulk Liquid Membranes for Separation and Recovery of Pharmaceutical Products},
journal = {Revista de Chimie},
volume = {69},
number = {11},
pages = {3257-3260},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.11.6725},
url = {https://revistadechimie.ro/Articles.asp?ID=6725}
}

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