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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3400-3405

https://doi.org/10.37358/RC.18.12.6758

Mariana Mateescu, Sanda Maria Doncea, Iuliana Raut, Cristina Lavinia Nistor, Ioneta Codrina Bujanca

Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics

Abstract:

The hydroxyapatite (HA) nano and microparticles were synthesized by wet-chemical precipitation in order to use them as drug carriers for biomedical applications. Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) were performed to assess their size, external morphology and chemical composition. The properties of HA particles as drug carriers for antibiotics delivery were evaluated with doxycycline and chloramphenicol. The amount of drug loading and release was determined by UV-Visible spectrophotometry. The antibacterial properties of loaded HA particles were evaluated using gram-positive Bacillus subtilis bacteria and gram-negative Pseudomonas aeruginosa bacteria. The synthesized particles of HA exhibit a high adsorption capacity (around 99%) and good controlled release properties for doxycycline. The adsorption of chloramphenicol on HA was extremely low (about 2%). According to the results, the compatibility between the drug and substrate is an important factor in the absorption process, and the hydroxyapatite is a very promising carrier for controlled release of antibiotics.
Keywords:
hydroxyapatite synthesis; drug carrier; drug release; antibacterial activity; doxycycline; chloramphenicol

Issue: 2018, Volume 69, Issue 12
Pages: 3400-3405
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6758
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MATEESCU, M., DONCEA, S.M., RAUT, I., NISTOR, C.L., BUJANCA, I.C., Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics, Rev. Chim., 69(12), 2018, 3400-3405.

Vancouver
Mateescu M, Doncea SM, Raut I, Nistor CL, Bujanca IC. Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics. Rev. Chim.[internet]. 2018 Dec;69(12):3400-3405. Available from: https://doi.org/10.37358/RC.18.12.6758


APA 6th edition
Mateescu, M., Doncea, S.M., Raut, I., Nistor, C.L. & Bujanca, I.C. (2018). Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics. Revista de Chimie, 69(12), 3400-3405. https://doi.org/10.37358/RC.18.12.6758


Harvard
Mateescu, M., Doncea, S.M., Raut, I., Nistor, C.L., Bujanca, I.C. (2018). 'Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics', Revista de Chimie, 69(12), pp. 3400-3405. https://doi.org/10.37358/RC.18.12.6758


IEEE
M. Mateescu, S.M. Doncea, I. Raut, C.L. Nistor, I.C. Bujanca, "Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics". Revista de Chimie, vol. 69, no. 12, pp. 3400-3405, 2018. [online]. https://doi.org/10.37358/RC.18.12.6758


Text
Mariana Mateescu, Sanda Maria Doncea, Iuliana Raut, Cristina Lavinia Nistor, Ioneta Codrina Bujanca,
Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3400-3405,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6758.
(https://revistadechimie.ro/Articles.asp?ID=6758)
Keywords: hydroxyapatite synthesis; drug carrier; drug release; antibacterial activity; doxycycline; chloramphenicol


RIS
TY - JOUR
T1 - Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics
A1 - Mateescu, Mariana
A2 - Doncea, Sanda Maria
A3 - Raut, Iuliana
A4 - Nistor, Cristina Lavinia
A5 - Bujanca, Ioneta Codrina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3400
EP - 3405
UR - https://doi.org/10.37358/RC.18.12.6758
KW - hydroxyapatite synthesis
KW - drug carrier
KW - drug release
KW - antibacterial activity
KW - doxycycline
KW - chloramphenicol
ER -


BibTex
@article{RevCh2018P3400,
author = {Mateescu Mariana and Doncea Sanda Maria and Raut Iuliana and Nistor Cristina Lavinia and Bujanca Ioneta Codrina},
title = {Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3400-3405},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6758},
url = {https://revistadechimie.ro/Articles.asp?ID=6758}
}
 
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