Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System

Taga (Sapunaru), Olga Valerica; Koncsag, Claudia Irina; Mares, Alina Monica; Jinescu, Gheorghita

Olga Valerica Taga (Sapunaru), Claudia Irina Koncsag, Alina Monica Mares, Gheorghita Jinescu

Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System

Abstract:

The reactive distillation is a way for the intensification of chemical processes by thermal integration into a single process of chemical reactions with products separation. Isopropyl lactate is an important intermediate for drug synthesis what can be synthesized through reactive distillation. Based on scientific studies in literature, a preliminary study was performed in a reactive distillation laboratory system, in order to obtain isopropyl lactate by esterification of lactic acid with isopropyl alcohol. The independent variables studied are: the alcohol/lactic acid molar ratio (R), the catalyst concentration (CA) and the number of theoretical trays in the fractionation zone (NTT). The experimental matrix was established for a 23 factorial experiment, by considering two levels for each variable: R=1 and 3 mole/mole; CA= 3 %wt and 5 %wt; NTT=1.9 and 2.9. A linear mathematical model was proposed to correlate the lactic acid conversion with the molar ratio of reactants, catalyst concentration and the number of theoretical plates in the column. The model shows that R and NTT are the important variables of the process while the acid concentration is less important, in the studied range. The correlation coefficient is R2=0.9978 and the statistical analysis ANOVA of the model’s coefficients proved they are significant at a confidence level of 95%, so the model is reliable.

Keywords:
reactive distillation; esterification; isopropyl lactate; mathematical modeling

Issue: 2018, Volume 69, Issue 12

Pages: 3423-3426

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6762

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TAGA (SAPUNARU), O.V., KONCSAG, C.I., MARES, A.M., JINESCU, G., Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System, Rev. Chim., 69(12), 2018, 3423-3426.

Vancouver
Taga (Sapunaru) OV, Koncsag CI, Mares AM, Jinescu G. Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System. Rev. Chim.[internet]. 2018 Dec;69(12):3423-3426. Available from: https://doi.org/10.37358/RC.18.12.6762

APA 6th edition
Taga (Sapunaru), O.V., Koncsag, C.I., Mares, A.M. & Jinescu, G. (2018). Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System. Revista de Chimie, 69(12), 3423-3426. https://doi.org/10.37358/RC.18.12.6762

Harvard
Taga (Sapunaru), O.V., Koncsag, C.I., Mares, A.M., Jinescu, G. (2018). 'Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System', Revista de Chimie, 69(12), pp. 3423-3426. https://doi.org/10.37358/RC.18.12.6762

IEEE
O.V. Taga(Sapunaru), C.I. Koncsag, A.M. Mares, G. Jinescu, "Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System". Revista de Chimie, vol. 69, no. 12, pp. 3423-3426, 2018. [online]. https://doi.org/10.37358/RC.18.12.6762

Text
Olga Valerica Taga(Sapunaru), Claudia Irina Koncsag, Alina Monica Mares, Gheorghita Jinescu,
Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3423-3426,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6762.
(https://revistadechimie.ro/Articles.asp?ID=6762)
Keywords: reactive distillation; esterification; isopropyl lactate; mathematical modeling

RIS
TY - JOUR
T1 - Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System
A1 - Taga (Sapunaru), Olga Valerica
A2 - Koncsag, Claudia Irina
A3 - Mares, Alina Monica
A4 - Jinescu, Gheorghita
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3423
EP - 3426
UR - https://doi.org/10.37358/RC.18.12.6762
KW - reactive distillation
KW - esterification
KW - isopropyl lactate
KW - mathematical modeling
ER -

BibTex
@article{RevCh2018P3423,
author = {Taga (Sapunaru) Olga Valerica and Koncsag Claudia Irina and Mares Alina Monica and Jinescu Gheorghita},
title = {Isopropyl Lactate Obtaining by Esterification in a Reactive Distillation System},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3423-3426},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6762},
url = {https://revistadechimie.ro/Articles.asp?ID=6762}
}

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