Free Radicals and Antioxidants in Ankylosing Spondylitis

Nechita, Aurel; Dinu, Ciprian; Ciubara, Alexandru Bogdan; Raftu, Gheorghe; Ancuta, Codrina

Aurel Nechita, Ciprian Dinu, Alexandru Bogdan Ciubara, Gheorghe Raftu, Codrina Ancuta

Free Radicals and Antioxidants in Ankylosing Spondylitis

Abstract:

Free radicals are widely recognized as overloaded atoms, molecules or compounds that become unstable when lacking an electron;they steal an electron from various macromolecules (e.g. DNA, RNA, proteins) to chemically stabilize, while preferred targets remains polyunsaturated fatty acids in their membranes. When electron theft produces a chain reaction, normal cell processes turn into a real chaos that ultimately degrades the normal functioning of the cell. Variance of free radicals existing or formed in nature as a result of many processes (ultraviolet radiation, gamma, action specific particles, etc.) makes extremely difficult their classification. A partof the oxygen molecules (O2) that have entered the body through breathing is divided and oxygen atoms become reactive (free radicals) damaging the cell wall by oxidation. Oxidative stress, a term widely used to characterise inflammatory disorders caused by destructive oxygen molecules called free radicals, may exacerbate inflammation and impair immune system response due to free radicals. Oxidative stress is defined as the imbalance between oxidants and antioxidants, in favour of oxidants, with destructive and pathogenic potential. Depending on intensity, oxidative stress can occur inside or outside the cell. Intracellular stress can lead to cell necrosis or a more or less marked disruption of the cell, and may be catastrophic in the case of a non-reproducible cell; the extracellular oxidative stress is cytotoxic. Although considered in the pathobiology of several inflammatory immune-mediated rheumatic conditions, the exact role of oxidative stress in ankylosing spondylitis is still debatable.

Keywords:
free radicals; oxidative stress; oxidation process; inflammation; ankylosing spondylitis

Issue: 2018, Volume 69, Issue 12

Pages: 3634-3637

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6808

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NECHITA, A., DINU, C., CIUBARA, A.B., RAFTU, G., ANCUTA, C., Free Radicals and Antioxidants in Ankylosing Spondylitis, Rev. Chim., 69(12), 2018, 3634-3637.

Vancouver
Nechita A, Dinu C, Ciubara AB, Raftu G, Ancuta C. Free Radicals and Antioxidants in Ankylosing Spondylitis. Rev. Chim.[internet]. 2018 Dec;69(12):3634-3637. Available from: https://doi.org/10.37358/RC.18.12.6808

APA 6th edition
Nechita, A., Dinu, C., Ciubara, A.B., Raftu, G. & Ancuta, C. (2018). Free Radicals and Antioxidants in Ankylosing Spondylitis. Revista de Chimie, 69(12), 3634-3637. https://doi.org/10.37358/RC.18.12.6808

Harvard
Nechita, A., Dinu, C., Ciubara, A.B., Raftu, G., Ancuta, C. (2018). 'Free Radicals and Antioxidants in Ankylosing Spondylitis', Revista de Chimie, 69(12), pp. 3634-3637. https://doi.org/10.37358/RC.18.12.6808

IEEE
A. Nechita, C. Dinu, A.B. Ciubara, G. Raftu, C. Ancuta, "Free Radicals and Antioxidants in Ankylosing Spondylitis". Revista de Chimie, vol. 69, no. 12, pp. 3634-3637, 2018. [online]. https://doi.org/10.37358/RC.18.12.6808

Text
Aurel Nechita, Ciprian Dinu, Alexandru Bogdan Ciubara, Gheorghe Raftu, Codrina Ancuta,
Free Radicals and Antioxidants in Ankylosing Spondylitis,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3634-3637,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6808.
(https://revistadechimie.ro/Articles.asp?ID=6808)
Keywords: free radicals; oxidative stress; oxidation process; inflammation; ankylosing spondylitis

RIS
TY - JOUR
T1 - Free Radicals and Antioxidants in Ankylosing Spondylitis
A1 - Nechita, Aurel
A2 - Dinu, Ciprian
A3 - Ciubara, Alexandru Bogdan
A4 - Raftu, Gheorghe
A5 - Ancuta, Codrina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3634
EP - 3637
UR - https://doi.org/10.37358/RC.18.12.6808
KW - free radicals
KW - oxidative stress
KW - oxidation process
KW - inflammation
KW - ankylosing spondylitis
ER -

BibTex
@article{RevCh2018P3634,
author = {Nechita Aurel and Dinu Ciprian and Ciubara Alexandru Bogdan and Raftu Gheorghe and Ancuta Codrina},
title = {Free Radicals and Antioxidants in Ankylosing Spondylitis},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3634-3637},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6808},
url = {https://revistadechimie.ro/Articles.asp?ID=6808}
}

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