Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice

Mazilu, Laura; Stanculeanu, Dana Lucia; Gheorghe, Andreea Daniela; Suceveanu, Adrian Paul; Hainarosie, Razvan; Parepa, Irinel Raluca; Bratu, Ovidiu; Diaconu, Camelia Cristina; Manuc, Daniela; Stoian, Anca Pantea; Suceveanu, Andra Iulia

Laura Mazilu, Dana Lucia Stanculeanu, Andreea Daniela Gheorghe, Adrian Paul Suceveanu, Razvan Hainarosie, Irinel Raluca Parepa, Ovidiu Bratu, Camelia Cristina Diaconu, Daniela Manuc, Anca Pantea Stoian, Andra Iulia Suceveanu

Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice

Abstract:

Lung cancer is the most common cause of cancer-related mortality, and non-small cell lung cancer (NSCLC) represents about 85% of all lung cancers. In the last years, novel targeted therapies have been developed and approved in the treatment of NSCLC. Angiogenesis is a very complex process, and cancer angiogenesis is the most important event concerning cancer growth, invasion and metastasis. VEGF signalling pathway plays a significant role in cancer angiogenesis, and it is demonstrated that VEGF levels are correlated with increased angiogenesis and with poor prognosis and metastasis in NSCLC patients. Bevacizumab is a recombinant humanised monoclonal IgG1 antibody, it is one of the first agent used for anti-angiogenic treatment, and it was approved for the treatment of non-squamous NSCLC in combination with chemotherapy.

Keywords:
lung cancer; bevacizumab; chemotherapy

Issue: 2018, Volume 69, Issue 12

Pages: 3644-3647

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6810

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MAZILU, L., STANCULEANU, D.L., GHEORGHE, A.D., SUCEVEANU, A.P., HAINAROSIE, R., PAREPA, I.R., BRATU, O., DIACONU, C.C., MANUC, D., STOIAN, A.P., SUCEVEANU, A.I., Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice, Rev. Chim., 69(12), 2018, 3644-3647.

Vancouver
Mazilu L, Stanculeanu DL, Gheorghe AD, Suceveanu AP, Hainarosie R, Parepa IR, Bratu O, Diaconu CC, Manuc D, Stoian AP, Suceveanu AI. Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice. Rev. Chim.[internet]. 2018 Dec;69(12):3644-3647. Available from: https://doi.org/10.37358/RC.18.12.6810

APA 6th edition
Mazilu, L., Stanculeanu, D.L., Gheorghe, A.D., Suceveanu, A.P., Hainarosie, R., Parepa, I.R.,... Suceveanu, A.I. (2018). Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice. Revista de Chimie, 69(12), 3644-3647. https://doi.org/10.37358/RC.18.12.6810

Harvard
Mazilu, L., Stanculeanu, D.L., Gheorghe, A.D., Suceveanu, A.P., Hainarosie, R., Parepa, I.R., Bratu, O., Diaconu, C.C., Manuc, D., Stoian, A.P., Suceveanu, A.I. (2018). 'Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice', Revista de Chimie, 69(12), pp. 3644-3647. https://doi.org/10.37358/RC.18.12.6810

IEEE
L. Mazilu, D.L. Stanculeanu, A.D. Gheorghe, A.P. Suceveanu, R. Hainarosie, I.R. Parepa, O. Bratu, C.C. Diaconu, D. Manuc, A.P. Stoian, A.I. Suceveanu, "Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice". Revista de Chimie, vol. 69, no. 12, pp. 3644-3647, 2018. [online]. https://doi.org/10.37358/RC.18.12.6810

Text
Laura Mazilu, Dana Lucia Stanculeanu, Andreea Daniela Gheorghe, Adrian Paul Suceveanu, Razvan Hainarosie, Irinel Raluca Parepa, Ovidiu Bratu, Camelia Cristina Diaconu, Daniela Manuc, Anca Pantea Stoian, Andra Iulia Suceveanu,
Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3644-3647,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6810.
(https://revistadechimie.ro/Articles.asp?ID=6810)
Keywords: lung cancer; bevacizumab; chemotherapy

RIS
TY - JOUR
T1 - Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice
A1 - Mazilu, Laura
A2 - Stanculeanu, Dana Lucia
A3 - Gheorghe, Andreea Daniela
A4 - Suceveanu, Adrian Paul
A5 - Hainarosie, Razvan
A6 - Parepa, Irinel Raluca
A7 - Bratu, Ovidiu
A8 - Diaconu, Camelia Cristina
A9 - Manuc, Daniela
A10 - Stoian, Anca Pantea
A11 - Suceveanu, Andra Iulia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3644
EP - 3647
UR - https://doi.org/10.37358/RC.18.12.6810
KW - lung cancer
KW - bevacizumab
KW - chemotherapy
ER -

BibTex
@article{RevCh2018P3644,
author = {Mazilu Laura and Stanculeanu Dana Lucia and Gheorghe Andreea Daniela and Suceveanu Adrian Paul and Hainarosie Razvan and Parepa Irinel Raluca and Bratu Ovidiu and Diaconu Camelia Cristina and Manuc Daniela and Stoian Anca Pantea and Suceveanu Andra Iulia},
title = {Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3644-3647},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6810},
url = {https://revistadechimie.ro/Articles.asp?ID=6810}
}

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