coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection

Taisescu, Citto Iulian; Demetrian, Alin; Biciusca, Viorel; Dricu, Anica; Artene, Stefan Alexandru; Cioc, Catalina; Taisescu, Oana

Citto Iulian Taisescu, Alin Demetrian, Viorel Biciusca, Anica Dricu, Stefan Alexandru Artene, Catalina Cioc, Oana Taisescu

coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection

Abstract:

Anemia associated with ribavirin (RBV) and interferon therapy in patients with chronic viral hepatitis C is a hemolytic, multifactorial adverse effect, in direct correlation with the RBV dose. Additionally, the anemic syndrome is worsened by the interferon-induced bone marrow suppression of erythroid precursors. The resulting anemia is associated with low production of erythropoietin, similar to anemia seen in HIV-infected patients or in those with cancer. Our study was performed on a group of 28 patients with viral hepatitis C treated with 3 MU interferon alfa 3 times a week and RBV 1000-1200 mg/day for 12 months. A normochromic normocytic anemia was observed, requiring a reduction of the RBV dose to 600 mg/day if the hemoglobin was below 10 g/dL and interrupted if the hemoglobin level was below 8.5 g/dL. In this case, reversibility can occur within a time interval of 4-8 weeks after discontinuation of treatment.

Keywords:
ribavirin; chronic viral hepatitis C; anemia

Issue: 2018, Volume 69, Issue 12

Pages: 3648-3652

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6811

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TAISESCU, C.I., DEMETRIAN, A., BICIUSCA, V., DRICU, A., ARTENE, S.A., CIOC, C., TAISESCU, O., coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection, Rev. Chim., 69(12), 2018, 3648-3652.

Vancouver
Taisescu CI, Demetrian A, Biciusca V, Dricu A, Artene SA, Cioc C, Taisescu O. coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection. Rev. Chim.[internet]. 2018 Dec;69(12):3648-3652. Available from: https://doi.org/10.37358/RC.18.12.6811

APA 6th edition
Taisescu, C.I., Demetrian, A., Biciusca, V., Dricu, A., Artene, S.A., Cioc, C. & Taisescu, O. (2018). coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection. Revista de Chimie, 69(12), 3648-3652. https://doi.org/10.37358/RC.18.12.6811

Harvard
Taisescu, C.I., Demetrian, A., Biciusca, V., Dricu, A., Artene, S.A., Cioc, C., Taisescu, O. (2018). 'coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection', Revista de Chimie, 69(12), pp. 3648-3652. https://doi.org/10.37358/RC.18.12.6811

IEEE
C.I. Taisescu, A. Demetrian, V. Biciusca, A. Dricu, S.A. Artene, C. Cioc, O. Taisescu, "coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection". Revista de Chimie, vol. 69, no. 12, pp. 3648-3652, 2018. [online]. https://doi.org/10.37358/RC.18.12.6811

Text
Citto Iulian Taisescu, Alin Demetrian, Viorel Biciusca, Anica Dricu, Stefan Alexandru Artene, Catalina Cioc, Oana Taisescu,
coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3648-3652,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6811.
(https://revistadechimie.ro/Articles.asp?ID=6811)
Keywords: ribavirin; chronic viral hepatitis C; anemia

RIS
TY - JOUR
T1 - coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection
A1 - Taisescu, Citto Iulian
A2 - Demetrian, Alin
A3 - Biciusca, Viorel
A4 - Dricu, Anica
A5 - Artene, Stefan Alexandru
A6 - Cioc, Catalina
A7 - Taisescu, Oana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3648
EP - 3652
UR - https://doi.org/10.37358/RC.18.12.6811
KW - ribavirin
KW - chronic viral hepatitis C
KW - anemia
ER -

BibTex
@article{RevCh2018P3648,
author = {Taisescu Citto Iulian and Demetrian Alin and Biciusca Viorel and Dricu Anica and Artene Stefan Alexandru and Cioc Catalina and Taisescu Oana},
title = {coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3648-3652},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6811},
url = {https://revistadechimie.ro/Articles.asp?ID=6811}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)