The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion

Cojocaru, Viorica; Dantes, Elena; Novac, Mariana Gabriela; Ionescu, Alexandra Maria; Ianosi, Edith Simona; Rusu, Elena; Nemes, Roxana Maria

Viorica Cojocaru, Elena Dantes, Mariana Gabriela Novac, Alexandra Maria Ionescu, Edith Simona Ianosi, Elena Rusu, Roxana Maria Nemes

The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion

Abstract:

The etiologic diagnosis of pleural effusion is often difficult, requiring invasive investigations to determine it. In Romania, tuberculosis is a frequent cause of pleural effusion, with the diagnosis of certainty being based on the bacteriological or histopathological examination. Adenosine deaminase (ADA) is an enzyme found in T lymphocytes, stimulated by Mycobacterium tuberculosis, which is why it is considered to be an essential marker of etiologic diagnosis in countries where the TB endemic is elevated. A case-control study was conducted in the Clinical Pneumophthisiology Hospital of Constanta, Romania, in patients diagnosed with tuberculous pleural effusion. The primary endpoint was to establish the cut-off value for ADA in supporting the positive diagnosis of TB pleural effusion, and the secondary objective was to identify the differences between TB pleural effusion and other etiologic types of pleural effusion. A cut-off of 55 UI has a good specificity (80%) and good sensitivity (85%). The study confirms other features of tuberculous pleural effusion as younger age, lower levels of white blood cells and neutrophils, increased number of lymphocytes in pleural fluid, low protein serum level, increased values of pleural lactic dehydrogenase (LDH) and pleural ADA.

Keywords:
adenosin deaminase (ADA); pleural effusion; tuberculosis

Issue: 2018, Volume 69, Issue 12

Pages: 3688-3691

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6820

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
COJOCARU, V., DANTES, E., NOVAC, M.G., IONESCU, A.M., IANOSI, E.S., RUSU, E., NEMES, R.M., The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion, Rev. Chim., 69(12), 2018, 3688-3691.

Vancouver
Cojocaru V, Dantes E, Novac MG, Ionescu AM, Ianosi ES, Rusu E, Nemes RM. The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion. Rev. Chim.[internet]. 2018 Dec;69(12):3688-3691. Available from: https://doi.org/10.37358/RC.18.12.6820

APA 6th edition
Cojocaru, V., Dantes, E., Novac, M.G., Ionescu, A.M., Ianosi, E.S., Rusu, E. & Nemes, R.M. (2018). The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion. Revista de Chimie, 69(12), 3688-3691. https://doi.org/10.37358/RC.18.12.6820

Harvard
Cojocaru, V., Dantes, E., Novac, M.G., Ionescu, A.M., Ianosi, E.S., Rusu, E., Nemes, R.M. (2018). 'The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion', Revista de Chimie, 69(12), pp. 3688-3691. https://doi.org/10.37358/RC.18.12.6820

IEEE
V. Cojocaru, E. Dantes, M.G. Novac, A.M. Ionescu, E.S. Ianosi, E. Rusu, R.M. Nemes, "The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion". Revista de Chimie, vol. 69, no. 12, pp. 3688-3691, 2018. [online]. https://doi.org/10.37358/RC.18.12.6820

Text
Viorica Cojocaru, Elena Dantes, Mariana Gabriela Novac, Alexandra Maria Ionescu, Edith Simona Ianosi, Elena Rusu, Roxana Maria Nemes,
The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3688-3691,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6820.
(https://revistadechimie.ro/Articles.asp?ID=6820)
Keywords: adenosin deaminase (ADA); pleural effusion; tuberculosis

RIS
TY - JOUR
T1 - The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion
A1 - Cojocaru, Viorica
A2 - Dantes, Elena
A3 - Novac, Mariana Gabriela
A4 - Ionescu, Alexandra Maria
A5 - Ianosi, Edith Simona
A6 - Rusu, Elena
A7 - Nemes, Roxana Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3688
EP - 3691
UR - https://doi.org/10.37358/RC.18.12.6820
KW - adenosin deaminase (ADA)
KW - pleural effusion
KW - tuberculosis
ER -

BibTex
@article{RevCh2018P3688,
author = {Cojocaru Viorica and Dantes Elena and Novac Mariana Gabriela and Ionescu Alexandra Maria and Ianosi Edith Simona and Rusu Elena and Nemes Roxana Maria},
title = {The Value of Adenosine Deaminase Enzime Level in the Positive Diagnosis of Tuberculous Pleural Effusion},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3688-3691},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6820},
url = {https://revistadechimie.ro/Articles.asp?ID=6820}
}

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