ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHORS'S PAGE NEWS, EVENTS
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Print 0034-7752
ISSN Online 2668-8212
Journal Metrics
* Impact Factor 2018-19: 1.605
* 5-Year IF: 1.34
* CiteScore: 1.23
* SNIP: 0.710
* SJR: 0.294
(academic-accelerator.com)

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
   Volume 57, 2006
   Volume 56, 2005
   Volume 55, 2004
   Volume 54, 2003
   Volume 53, 2002
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 1, 1-5

https://doi.org/10.37358/RC.19.1.6839

Andreea Creteanu, Alina Stefanache, Madalina Vieriu, Gladiola Tantaru, Lacramioara Ochiuz

Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate

Abstract:

The study is based on new oral matrix tablets based on Kollidon®SR and chitosan, formulated in order to optimize the low oral bioavailability of amiodarone, a class III antiarrhythmic drug. Pharmacotechnical characterization included the analysis of flowability and compressibility properties (flow time, friction coefficient, angle of repose, Hausner ratio, Carr Index), and of pharmaco-chemical characteristics (mass and dose uniformity, thickness, diameter, mechanical strength, friability, degree of softening, in vitro release profile) of the tablets obtained using direct compression method. The results obtained have shown that both Kollidon®SR and chitosan may be used as matrix forming agents when combined with amiodarone. In vitro dissolution tests revealed that the nine formulations studied provided a prolonged release of amiodarone when compared to an industrial pharmaceutical product formulated as conventional release tablets.
Keywords:
amiodarone; Kollidon®SR; chitosan; oral matrix tablets

Issue: 2019, Volume 70, Issue 1
Pages: 1-5
Publication date: 15/02/2019
https://doi.org/10.37358/RC.19.1.6839
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CRETEANU, A., STEFANACHE, A., VIERIU, M., TANTARU, G., OCHIUZ, L., Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate, Rev. Chim., 70(1), 2019, 1-5.

Vancouver
Creteanu A, Stefanache A, Vieriu M, Tantaru G, Ochiuz L. Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate. Rev. Chim.[internet]. 2019 Jan;70(1):1-5. Available from: https://doi.org/10.37358/RC.19.1.6839


APA 6th edition
Creteanu, A., Stefanache, A., Vieriu, M., Tantaru, G. & Ochiuz, L. (2019). Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate. Revista de Chimie, 70(1), 1-5. https://doi.org/10.37358/RC.19.1.6839


Harvard
Creteanu, A., Stefanache, A., Vieriu, M., Tantaru, G., Ochiuz, L. (2019). 'Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate', Revista de Chimie, 70(1), pp. 1-5. https://doi.org/10.37358/RC.19.1.6839


IEEE
A. Creteanu, A. Stefanache, M. Vieriu, G. Tantaru, L. Ochiuz, "Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate". Revista de Chimie, vol. 70, no. 1, pp. 1-5, 2019. [online]. https://doi.org/10.37358/RC.19.1.6839


Text
Andreea Creteanu, Alina Stefanache, Madalina Vieriu, Gladiola Tantaru, Lacramioara Ochiuz,
Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 1-5,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6839.
(https://revistadechimie.ro/Articles.asp?ID=6839)
Keywords: amiodarone; Kollidon®SR; chitosan; oral matrix tablets


RIS
TY - JOUR
T1 - Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate
A1 - Creteanu, Andreea
A2 - Stefanache, Alina
A3 - Vieriu, Madalina
A4 - Tantaru, Gladiola
A5 - Ochiuz, Lacramioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 1
EP - 5
UR - https://doi.org/10.37358/RC.19.1.6839
KW - amiodarone
KW - Kollidon®SR
KW - chitosan
KW - oral matrix tablets
ER -


BibTex
@article{RevCh2019P1,
author = {Creteanu Andreea and Stefanache Alina and Vieriu Madalina and Tantaru Gladiola and Ochiuz Lacramioara},
title = {Study on the Formulation and Pharmacotechnical Characterization of Hydrophilic Matrix Tables with Amiodarone Chlorhydrate},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {1-5},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6839},
url = {https://revistadechimie.ro/Articles.asp?ID=6839}
}
 
Views number: 693    |     Downloads number: 123  
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
 * Author Payments
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Open Access Policy
 Search Authors
 LATEST NEWS
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice