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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 1, 13-17

https://doi.org/10.37358/RC.19.1.6841

Stefania-Felicia Barbuceanu, Octavian Tudorel Olaru, Laura-Ileana Socea, Constantin Draghici, Gabriel Saramet, Stelian Baraitareanu, Bogdan Socea, Florica Barbuceanu

S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation

Abstract:

This paper presents synthesis, characterization and cytotoxicity assessment of six S-alkylated 1,2,4-triazoles derivatives that were obtained by treatment of some 1,2,4-triazole-3-thiones containing in the molecule phenylsulfonylphenyl and propyl or 4-bromophenylsulfonylphenyl and 4-methoxyphenyl fragments with different alkylation agents (ethyl bromide, ethyl chloroacetate or phenacyl bromide) in basic media. The synthesized compounds were physico-chemically characterized and the IR, 1H-NMR, 13C-NMR spectra were consistent with the assigned structures. The cytotoxicity of S-alkylated derivatives was evaluated on Daphnia magna crustacean.
Keywords:
1;2;4-triazole-3-thione; alkylation; cytotoxic effect; Daphnia magna

Issue: 2019, Volume 70, Issue 1
Pages: 13-17
Publication date: 2019/2/15
https://doi.org/10.37358/RC.19.1.6841
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BARBUCEANU, S., OLARU, O.T., SOCEA, L., DRAGHICI, C., SARAMET, G., BARAITAREANU, S., SOCEA, B., BARBUCEANU, F., S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation, Rev. Chim., 70(1), 2019, 13-17.

Vancouver
Barbuceanu S, Olaru OT, Socea L, Draghici C, Saramet G, Baraitareanu S, Socea B, Barbuceanu F. S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation. Rev. Chim.[internet]. 2019 Jan;70(1):13-17. Available from: https://doi.org/10.37358/RC.19.1.6841


APA 6th edition
Barbuceanu, S., Olaru, O.T., Socea, L., Draghici, C., Saramet, G., Baraitareanu, S., Socea, B. & Barbuceanu, F. (2019). S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation. Revista de Chimie, 70(1), 13-17. https://doi.org/10.37358/RC.19.1.6841


Harvard
Barbuceanu, S., Olaru, O.T., Socea, L., Draghici, C., Saramet, G., Baraitareanu, S., Socea, B., Barbuceanu, F. (2019). 'S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation', Revista de Chimie, 70(1), pp. 13-17. https://doi.org/10.37358/RC.19.1.6841


IEEE
S. Barbuceanu, O.T. Olaru, L. Socea, C. Draghici, G. Saramet, S. Baraitareanu, B. Socea, F. Barbuceanu, "S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation". Revista de Chimie, vol. 70, no. 1, pp. 13-17, 2019. [online]. https://doi.org/10.37358/RC.19.1.6841


Text
Stefania-Felicia Barbuceanu, Octavian Tudorel Olaru, Laura-Ileana Socea, Constantin Draghici, Gabriel Saramet, Stelian Baraitareanu, Bogdan Socea, Florica Barbuceanu,
S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 13-17,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6841.
(https://revistadechimie.ro/Articles.asp?ID=6841)
Keywords: 1;2;4-triazole-3-thione; alkylation; cytotoxic effect; Daphnia magna


RIS
TY - JOUR
T1 - S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation
A1 - Barbuceanu, Stefania-Felicia
A2 - Olaru, Octavian Tudorel
A3 - Socea, Laura-Ileana
A4 - Draghici, Constantin
A5 - Saramet, Gabriel
A6 - Baraitareanu, Stelian
A7 - Socea, Bogdan
A8 - Barbuceanu, Florica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 13
EP - 17
UR - https://doi.org/10.37358/RC.19.1.6841
KW - 1
KW - 2
KW - 4-triazole-3-thione
KW - alkylation
KW - cytotoxic effect
KW - Daphnia magna
ER -


BibTex
@article{RevCh2019P13,
author = {Barbuceanu Stefania-Felicia and Olaru Octavian Tudorel and Socea Laura-Ileana and Draghici Constantin and Saramet Gabriel and Baraitareanu Stelian and Socea Bogdan and Barbuceanu Florica},
title = {S-Alkylated 1,2,4-Triazoles Derivatives Synthesis, spectral analysis and cytotoxicity evaluation},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {13-17},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6841},
url = {https://revistadechimie.ro/Articles.asp?ID=6841}
}
 
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