TERT Genotyping for Evaluation of Reproduction Failure

Meszaros, Noemi; Andreescu, Nicoleta Ioana; Farcas, Simona Sorina; Dobrescu, Andreea Iulia; Stelea, Lavinia Elena; Mathe, Endre; Porumb, Anca; Puiu, Maria

Noemi Meszaros, Nicoleta Ioana Andreescu, Simona Sorina Farcas, Andreea Iulia Dobrescu, Lavinia Elena Stelea, Endre Mathe, Anca Porumb, Maria Puiu

TERT Genotyping for Evaluation of Reproduction Failure

Abstract:

Reproduction failure was associated with advanced maternal age, but the mechanism underlying this events were still under debate. Telomere length of the oocytes has been correlated with the embryo quality, the chance of successful pregnancy and further development of the conception. The study included a total of 35 women with pregnancy loss and 35 fertile proven females. Cytogenetic analysis of the chorionic villi was done for all the women from the study lot that exhibit a pregnancy loss. The TERT rs2736100 genotyping was performed after enrollment of the last patient, and the laboratory staff was blinded to the patients’ data. Comparing the frequency of the genotypes in the study groups was found that in the study lot the AC genotypes was the most frequent (51.4%), while in the control lot the AA genotypes was the prevalent genotype (60%). The difference between genotypes frequencies in the study lot and the control lot were statistically significant. To our knowledge, this is the first study addressing the potential role of a single nucleotide variant in TERT gene in relation with miscarriage.

Keywords:
TERT gene; miscarriage; rs2736100

Issue: 2019, Volume 70, Issue 1

Pages: 195-198

Publication date: 2019/2/15

https://doi.org/10.37358/RC.19.1.6880

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MESZAROS, N., ANDREESCU, N.I., FARCAS, S.S., DOBRESCU, A.I., STELEA, L.E., MATHE, E., PORUMB, A., PUIU, M., TERT Genotyping for Evaluation of Reproduction Failure, Rev. Chim., 70(1), 2019, 195-198.

Vancouver
Meszaros N, Andreescu NI, Farcas SS, Dobrescu AI, Stelea LE, Mathe E, Porumb A, Puiu M. TERT Genotyping for Evaluation of Reproduction Failure. Rev. Chim.[internet]. 2019 Jan;70(1):195-198. Available from: https://doi.org/10.37358/RC.19.1.6880

APA 6th edition
Meszaros, N., Andreescu, N.I., Farcas, S.S., Dobrescu, A.I., Stelea, L.E., Mathe, E., Porumb, A. & Puiu, M. (2019). TERT Genotyping for Evaluation of Reproduction Failure. Revista de Chimie, 70(1), 195-198. https://doi.org/10.37358/RC.19.1.6880

Harvard
Meszaros, N., Andreescu, N.I., Farcas, S.S., Dobrescu, A.I., Stelea, L.E., Mathe, E., Porumb, A., Puiu, M. (2019). 'TERT Genotyping for Evaluation of Reproduction Failure', Revista de Chimie, 70(1), pp. 195-198. https://doi.org/10.37358/RC.19.1.6880

IEEE
N. Meszaros, N.I. Andreescu, S.S. Farcas, A.I. Dobrescu, L.E. Stelea, E. Mathe, A. Porumb, M. Puiu, "TERT Genotyping for Evaluation of Reproduction Failure". Revista de Chimie, vol. 70, no. 1, pp. 195-198, 2019. [online]. https://doi.org/10.37358/RC.19.1.6880

Text
Noemi Meszaros, Nicoleta Ioana Andreescu, Simona Sorina Farcas, Andreea Iulia Dobrescu, Lavinia Elena Stelea, Endre Mathe, Anca Porumb, Maria Puiu,
TERT Genotyping for Evaluation of Reproduction Failure,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 195-198,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6880.
(https://revistadechimie.ro/Articles.asp?ID=6880)
Keywords: TERT gene; miscarriage; rs2736100

RIS
TY - JOUR
T1 - TERT Genotyping for Evaluation of Reproduction Failure
A1 - Meszaros, Noemi
A2 - Andreescu, Nicoleta Ioana
A3 - Farcas, Simona Sorina
A4 - Dobrescu, Andreea Iulia
A5 - Stelea, Lavinia Elena
A6 - Mathe, Endre
A7 - Porumb, Anca
A8 - Puiu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 195
EP - 198
UR - https://doi.org/10.37358/RC.19.1.6880
KW - TERT gene
KW - miscarriage
KW - rs2736100
ER -

BibTex
@article{RevCh2019P195,
author = {Meszaros Noemi and Andreescu Nicoleta Ioana and Farcas Simona Sorina and Dobrescu Andreea Iulia and Stelea Lavinia Elena and Mathe Endre and Porumb Anca and Puiu Maria},
title = {TERT Genotyping for Evaluation of Reproduction Failure},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {195-198},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6880},
url = {https://revistadechimie.ro/Articles.asp?ID=6880}
}

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