Noemi Meszaros, Nicoleta Ioana Andreescu, Simona Sorina Farcas, Andreea Iulia Dobrescu, Lavinia Elena Stelea, Endre Mathe, Anca Porumb, Maria Puiu
TERT Genotyping for Evaluation of Reproduction Failure
Abstract:
Reproduction failure was associated with advanced maternal age, but the mechanism underlying this events were still under debate. Telomere length of the oocytes has been correlated with the embryo quality, the chance of successful pregnancy and further development of the conception. The study included a total of 35 women with pregnancy loss and 35 fertile proven females. Cytogenetic analysis of the chorionic villi was done for all the women from the study lot that exhibit a pregnancy loss. The TERT rs2736100 genotyping was performed after enrollment of the last patient, and the laboratory staff was blinded to the patients’ data. Comparing the frequency of the genotypes in the study groups was found that in the study lot the AC genotypes was the most frequent (51.4%), while in the control lot the AA genotypes was the prevalent genotype (60%). The difference between genotypes frequencies in the study lot and the control lot were statistically significant. To our knowledge, this is the first study addressing the potential role of a single nucleotide variant in TERT gene in relation with miscarriage.
Cite this article as: MESZAROS, N., ANDREESCU, N.I., FARCAS, S.S., DOBRESCU, A.I., STELEA, L.E., MATHE, E., PORUMB, A., PUIU, M., TERT Genotyping for Evaluation of Reproduction Failure, Rev. Chim., 70(1), 2019, 195-198.
Vancouver Meszaros N, Andreescu NI, Farcas SS, Dobrescu AI, Stelea LE, Mathe E, Porumb A, Puiu M. TERT Genotyping for Evaluation of Reproduction Failure. Rev. Chim.[internet]. 2019 Jan;70(1):195-198. Available from: https://doi.org/10.37358/RC.19.1.6880
APA 6th edition Meszaros, N., Andreescu, N.I., Farcas, S.S., Dobrescu, A.I., Stelea, L.E., Mathe, E., Porumb, A. & Puiu, M. (2019). TERT Genotyping for Evaluation of Reproduction Failure. Revista de Chimie, 70(1), 195-198. https://doi.org/10.37358/RC.19.1.6880
Harvard Meszaros, N., Andreescu, N.I., Farcas, S.S., Dobrescu, A.I., Stelea, L.E., Mathe, E., Porumb, A., Puiu, M. (2019). 'TERT Genotyping for Evaluation of Reproduction Failure', Revista de Chimie, 70(1), pp. 195-198. https://doi.org/10.37358/RC.19.1.6880
IEEE N. Meszaros, N.I. Andreescu, S.S. Farcas, A.I. Dobrescu, L.E. Stelea, E. Mathe, A. Porumb, M. Puiu, "TERT Genotyping for Evaluation of Reproduction Failure". Revista de Chimie, vol. 70, no. 1, pp. 195-198, 2019. [online]. https://doi.org/10.37358/RC.19.1.6880
Text Noemi Meszaros, Nicoleta Ioana Andreescu, Simona Sorina Farcas, Andreea Iulia Dobrescu, Lavinia Elena Stelea, Endre Mathe, Anca Porumb, Maria Puiu, TERT Genotyping for Evaluation of Reproduction Failure, Revista de Chimie, Volume 70, Issue 1, 2019, Pages 195-198, ISSN 2668-8212, https://doi.org/10.37358/RC.19.1.6880. (https://revistadechimie.ro/Articles.asp?ID=6880) Keywords: TERT gene; miscarriage; rs2736100
RIS TY - JOUR T1 - TERT Genotyping for Evaluation of Reproduction Failure A1 - Meszaros, Noemi A2 - Andreescu, Nicoleta Ioana A3 - Farcas, Simona Sorina A4 - Dobrescu, Andreea Iulia A5 - Stelea, Lavinia Elena A6 - Mathe, Endre A7 - Porumb, Anca A8 - Puiu, Maria JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2019 VL - 70 IS - 1 SP - 195 EP - 198 UR - https://doi.org/10.37358/RC.19.1.6880 KW - TERT gene KW - miscarriage KW - rs2736100 ER -
BibTex @article{RevCh2019P195, author = {Meszaros Noemi and Andreescu Nicoleta Ioana and Farcas Simona Sorina and Dobrescu Andreea Iulia and Stelea Lavinia Elena and Mathe Endre and Porumb Anca and Puiu Maria}, title = {TERT Genotyping for Evaluation of Reproduction Failure}, journal = {Revista de Chimie}, volume = {70}, number = {1}, pages = {195-198}, year = {2019}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.19.1.6880}, url = {https://revistadechimie.ro/Articles.asp?ID=6880} }
