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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 1, 236-238

https://doi.org/10.37358/RC.19.1.6890

Delia Hinganu, Cristinel Ionel Stan, Corina Ciupilan, Alexandru Grigorovici, Virgil Bulimar, Lucia Corina Dima Cozma, Marius Valeriu Hinganu

Anatomical and Immunohistochemical Evaluation of Colorectal Cancer

Abstract:

Colorectal cancer is a malignant disease with high morbidity and mortality. Ki-67 is a marker of cell proliferation associated with a low survival in colorectal cancer patients. Its expression is increased in patients with Dukes C or D colorectal cancer versus those in stage A or B. The purpose of the study is to evaluate the immunohistochemical expression of the Ki-67 marker in colorectal adenocarcinomas. The study was performed on a group of 28 patients diagnosed with rectal cancer. We made the histopathological and immunohistochemical evaluation of patients in the study group. The evaluation was performed on the sections stained with hematoxylin-eosin, and for mucinous forms, on sections stained with alcian blue. The topography of the Ki-67 reaction is strictly nuclear, evident in areas with intense proliferative activity. In cases with a strong positive response to Ki-67, the prognosis is worse, with invasion of the perirectal tissues and metastases. The lack of Ki-67 expression in nearby neoplastic tissues suggests that cancerous tissue proliferates in a pathway that it is not correlated with adjacent tissues. The Ki-67 could be useful in the prognosis of patients with colorectal cancer.
Keywords:
colorectal cancer; Ki-67 immunohistochemical expression; prognosis

Issue: 2019, Volume 70, Issue 1
Pages: 236-238
Publication date: 15/02/2019
https://doi.org/10.37358/RC.19.1.6890
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
HINGANU, D., STAN, C.I., CIUPILAN, C., GRIGOROVICI, A., BULIMAR, V., COZMA, L.C.D., HINGANU, M.V., Anatomical and Immunohistochemical Evaluation of Colorectal Cancer, Rev. Chim., 70(1), 2019, 236-238.

Vancouver
Hinganu D, Stan CI, Ciupilan C, Grigorovici A, Bulimar V, Cozma LCD, Hinganu MV. Anatomical and Immunohistochemical Evaluation of Colorectal Cancer. Rev. Chim.[internet]. 2019 Jan;70(1):236-238. Available from: https://doi.org/10.37358/RC.19.1.6890


APA 6th edition
Hinganu, D., Stan, C.I., Ciupilan, C., Grigorovici, A., Bulimar, V., Cozma, L.C.D. & Hinganu, M.V. (2019). Anatomical and Immunohistochemical Evaluation of Colorectal Cancer. Revista de Chimie, 70(1), 236-238. https://doi.org/10.37358/RC.19.1.6890


Harvard
Hinganu, D., Stan, C.I., Ciupilan, C., Grigorovici, A., Bulimar, V., Cozma, L.C.D., Hinganu, M.V. (2019). 'Anatomical and Immunohistochemical Evaluation of Colorectal Cancer', Revista de Chimie, 70(1), pp. 236-238. https://doi.org/10.37358/RC.19.1.6890


IEEE
D. Hinganu, C.I. Stan, C. Ciupilan, A. Grigorovici, V. Bulimar, L.C.D. Cozma, M.V. Hinganu, "Anatomical and Immunohistochemical Evaluation of Colorectal Cancer". Revista de Chimie, vol. 70, no. 1, pp. 236-238, 2019. [online]. https://doi.org/10.37358/RC.19.1.6890


Text
Delia Hinganu, Cristinel Ionel Stan, Corina Ciupilan, Alexandru Grigorovici, Virgil Bulimar, Lucia Corina Dima Cozma, Marius Valeriu Hinganu,
Anatomical and Immunohistochemical Evaluation of Colorectal Cancer,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 236-238,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6890.
(https://revistadechimie.ro/Articles.asp?ID=6890)
Keywords: colorectal cancer; Ki-67 immunohistochemical expression; prognosis


RIS
TY - JOUR
T1 - Anatomical and Immunohistochemical Evaluation of Colorectal Cancer
A1 - Hinganu, Delia
A2 - Stan, Cristinel Ionel
A3 - Ciupilan, Corina
A4 - Grigorovici, Alexandru
A5 - Bulimar, Virgil
A6 - Cozma, Lucia Corina Dima
A7 - Hinganu, Marius Valeriu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 236
EP - 238
UR - https://doi.org/10.37358/RC.19.1.6890
KW - colorectal cancer
KW - Ki-67 immunohistochemical expression
KW - prognosis
ER -


BibTex
@article{RevCh2019P236,
author = {Hinganu Delia and Stan Cristinel Ionel and Ciupilan Corina and Grigorovici Alexandru and Bulimar Virgil and Cozma Lucia Corina Dima and Hinganu Marius Valeriu},
title = {Anatomical and Immunohistochemical Evaluation of Colorectal Cancer},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {236-238},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6890},
url = {https://revistadechimie.ro/Articles.asp?ID=6890}
}
 
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