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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 1, 259-262

https://doi.org/10.37358/RC.19.1.6895

Afrodita Doina Marculescu, Cristian-Catalin Gavat, Aurel Nechita, Gabi Topor, Leonard Vasile Vasilescu, Mihaela Debita, Elena Roxana Axente, Carmen Lucia Trinca, Lucretia Anghel

Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets

Abstract:

The aim of this research was to exactly quantify pure sodium metamizole from tablets , using a spectrophotometric analysis in Visible range. The method applied has been subjected to a validation protocal which consisted in analyzing the following parameters: linearity of the method, detection limit (LD) , quantitation limit (LQ). Following actual dosing, pure sodium metamizole amount in tablet of pharmaceutical was found to be 477.477 mg assigned to a percentage content of 95.495 %, very close to official declared amount (500 mg), with an maximum average percentage deviation of only 4.505 % from the official declared active substance content. This value was situated below the maximum admissible percentage deviation from stated active substance content (± 5%), established by Romanian Pharmacopoeia, X-th Edition rules.
Keywords:
sodium metamizole; detection limit; quantitation limit

Issue: 2019, Volume 70, Issue 1
Pages: 259-262
Publication date: 15/02/2019
https://doi.org/10.37358/RC.19.1.6895
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MARCULESCU, A.D., GAVAT, C., NECHITA, A., TOPOR, G., VASILESCU, L.V., DEBITA, M., AXENTE, E.R., TRINCA, C.L., ANGHEL, L., Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets, Rev. Chim., 70(1), 2019, 259-262.

Vancouver
Marculescu AD, Gavat C, Nechita A, Topor G, Vasilescu LV, Debita M, Axente ER, Trinca CL, Anghel L. Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets. Rev. Chim.[internet]. 2019 Jan;70(1):259-262. Available from: https://doi.org/10.37358/RC.19.1.6895


APA 6th edition
Marculescu, A.D., Gavat, C., Nechita, A., Topor, G., Vasilescu, L.V., Debita, M.,... Anghel, L. (2019). Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets. Revista de Chimie, 70(1), 259-262. https://doi.org/10.37358/RC.19.1.6895


Harvard
Marculescu, A.D., Gavat, C., Nechita, A., Topor, G., Vasilescu, L.V., Debita, M., Axente, E.R., Trinca, C.L., Anghel, L. (2019). 'Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets', Revista de Chimie, 70(1), pp. 259-262. https://doi.org/10.37358/RC.19.1.6895


IEEE
A.D. Marculescu, C. Gavat, A. Nechita, G. Topor, L.V. Vasilescu, M. Debita, E.R. Axente, C.L. Trinca, L. Anghel, "Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets". Revista de Chimie, vol. 70, no. 1, pp. 259-262, 2019. [online]. https://doi.org/10.37358/RC.19.1.6895


Text
Afrodita Doina Marculescu, Cristian-Catalin Gavat, Aurel Nechita, Gabi Topor, Leonard Vasile Vasilescu, Mihaela Debita, Elena Roxana Axente, Carmen Lucia Trinca, Lucretia Anghel,
Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 259-262,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6895.
(https://revistadechimie.ro/Articles.asp?ID=6895)
Keywords: sodium metamizole; detection limit; quantitation limit


RIS
TY - JOUR
T1 - Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets
A1 - Marculescu, Afrodita Doina
A2 - Gavat, Cristian-Catalin
A3 - Nechita, Aurel
A4 - Topor, Gabi
A5 - Vasilescu, Leonard Vasile
A6 - Debita, Mihaela
A7 - Axente, Elena Roxana
A8 - Trinca, Carmen Lucia
A9 - Anghel, Lucretia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 259
EP - 262
UR - https://doi.org/10.37358/RC.19.1.6895
KW - sodium metamizole
KW - detection limit
KW - quantitation limit
ER -


BibTex
@article{RevCh2019P259,
author = {Marculescu Afrodita Doina and Gavat Cristian-Catalin and Nechita Aurel and Topor Gabi and Vasilescu Leonard Vasile and Debita Mihaela and Axente Elena Roxana and Trinca Carmen Lucia and Anghel Lucretia},
title = {Investigation of linearity, detection limit (LD) and quantitation limit(LQ) of active substance from pharmaceutical tablets},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {259-262},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6895},
url = {https://revistadechimie.ro/Articles.asp?ID=6895}
}
 
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