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REVISTA DE CHIMIE
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie, Volume 70, Issue 1, pp. 350-354 (2019)
https://doi.org/10.37358/RC.19.1.6914

Victor Vlad Costan, Anca Sava, Alexandru Carauleanu, Claudia Florida Costea, Andrei Ionut Cucu, Gabriela Dimitriu, Gabriela Florenta Dumitrescu, Nicoleta Dumitrescu, Maria Silvia Stoicescu, Gheorghe Raftu, Mihaela Dana Turliuc

Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit

Abstract:

Cavernous venous malformation (CVM) is the most common primary vascular lesion of the orbit. The aim of this study is to present authors ‘experience regarding fourteen patients with orbital CVM (so-called cavernous hemangioma) and identify their clinical and histopathological particular characteristics. From 2010 to 2017 a total of 14 patients were diagnosed with orbital cavernous hemangiomas and treated by the authors. Patients’ socio-demographic, clinical, radiological, and surgical findings were retrospectively retrieved from medical records and analyzed. Diagnosis of a cavernous hemangioma was confirmed histologically in all cases. Results: All 14 patients were females, with a mean age of 44.2 years old, ranging from 13 years to 57 years. The left orbit was affected in eleven (78.57%) cases. A painless, gradually progressive proptosis and visual disturbance were the main clinical signs. In four (28.57%) cases, the lesion was incidentally discovered at imaging evaluations for persistent headache. All patients were accurately diagnosed preoperatively based on computed tomography (CT) exam or magnetic resonance imaging (MRI). The tumors were removed successfully by anterior orbitotomy. Transconjunctival approach proved to be an important surgical procedure in their treatment, with excellent results and a low risk of complications. Histologically, all lesions revealed large vascular channels with endothelium lining and multilaminar smooth muscle layers in their walls, but also nests of small capillary channels in interstitium. No intravascular thrombosis or stromal lymphocytes could be seen. Orbital cavernous hemangiomas presented clinical, imaging and histological features of a benign lesion. Having to deal with extraconal lesions, we successfully used anterior orbitotomy, mainly the transconjuctival approach, with no complications or recurrences after a six-month follow-up period. Histologically, all lesions revealed images being most closely to dysplastic veins. So, we concluded that the so-called orbital cavernous hemangioma was rather a cavernous venous malformation.
Keywords:
orbit; cavernous hemangioma; cavernous venous malformation; histological examination

Issue: 2019 Volume 70, Number 1
Pages: 350-354
https://doi.org/10.37358/RC.19.1.6914
download pdf   Download Pdf Article
Citation Styles
Cite this article as:
COSTAN, V.V., SAVA, A., CARAULEANU, A., COSTEA, C.F., CUCU, A.I., DIMITRIU, G., DUMITRESCU, G.F., DUMITRESCU, N., STOICESCU, M.S., RAFTU, G., TURLIUC, M.D., Rev.Chim., 70, no. 1, 2019, p. 350

Vancouver
Costan VV, Sava A, Carauleanu A, Costea CF, Cucu AI, Dimitriu G, Dumitrescu GF, Dumitrescu N, Stoicescu MS, Raftu G, Turliuc MD. Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit. REV.CHIM.[internet]. 2019 Jan;70(1):350-354. Available from: https://doi.org/10.37358/RC.19.1.6914


APA 6th edition
Costan, V.V., Sava, A., Carauleanu, A., Costea, C.F., Cucu, A.I., Dimitriu, G.,... Turliuc, M.D. (2019). Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit. Revista de Chimie, 70(1), 350-354. https://doi.org/10.37358/RC.19.1.6914


Harvard
Costan, V.V., Sava, A., Carauleanu, A., Costea, C.F., Cucu, A.I., Dimitriu, G., Dumitrescu, G.F., Dumitrescu, N., Stoicescu, M.S., Raftu, G., Turliuc, M.D. (2019). 'Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit', Revista de Chimie, 70(1), pp. 350-354. https://doi.org/10.37358/RC.19.1.6914


IEEE
V.V. Costan, A. Sava, A. Carauleanu, C.F. Costea, A.I. Cucu, G. Dimitriu, G.F. Dumitrescu, N. Dumitrescu, M.S. Stoicescu, G. Raftu, M.D. Turliuc, "Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit". Revista de Chimie, vol. 70, no. 1, pp. 350-354, 2019. [online]. https://doi.org/10.37358/RC.19.1.6914


Text
Victor Vlad Costan, Anca Sava, Alexandru Carauleanu, Claudia Florida Costea, Andrei Ionut Cucu, Gabriela Dimitriu, Gabriela Florenta Dumitrescu, Nicoleta Dumitrescu, Maria Silvia Stoicescu, Gheorghe Raftu, Mihaela Dana Turliuc,
Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 350-354,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6914.
(https://revistadechimie.ro/Articles.asp?ID=6914)
Keywords: orbit; cavernous hemangioma; cavernous venous malformation; histological examination


RIS
TY - JOUR
T1 - Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit
A1 - Costan, Victor Vlad
A2 - Sava, Anca
A3 - Carauleanu, Alexandru
A4 - Costea, Claudia Florida
A5 - Cucu, Andrei Ionut
A6 - Dimitriu, Gabriela
A7 - Dumitrescu, Gabriela Florenta
A8 - Dumitrescu, Nicoleta
A9 - Stoicescu, Maria Silvia
A10 - Raftu, Gheorghe
A11 - Turliuc, Mihaela Dana
JF - Revista de Chimie
JO - Rev.Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 350
EP - 354
UR - https://doi.org/10.37358/RC.19.1.6914
KW - orbit
KW - cavernous hemangioma
KW - cavernous venous malformation
KW - histological examination
ER -


BibTex
@article{RevCh2019P350,
author = {Costan Victor Vlad and Sava Anca and Carauleanu Alexandru and Costea Claudia Florida and Cucu Andrei Ionut and Dimitriu Gabriela and Dumitrescu Gabriela Florenta and Dumitrescu Nicoleta and Stoicescu Maria Silvia and Raftu Gheorghe and Turliuc Mihaela Dana},
title = {Histopathological and Clinical Characteristics of Surgically Removed Cavernous Venous Malformations (so-called Cavernous Hemangiomas) of the Orbit},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {350-354},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6914},
url = {https://revistadechimie.ro/Articles.asp?ID=6914}
}
 
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