Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration

Iorga, Raluca Eugenia; Danulescu, Razvana Sorina Munteanu; Ozturk, Manuela; Costin, Danut

Raluca Eugenia Iorga, Razvana Sorina Munteanu Danulescu, Manuela Ozturk, Danut Costin

Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration

Abstract:

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. Were monitored the evolution of oxidative stress markers before and after treatment. This is a case-control study, which included 59 patients diagnosed with AMD and 64 healthy controls. According to the AREDS classification, the patients were divided into two classes, moderate and severe form AMD and were treated with antioxidants, neurotrophic drugs, intravitreal injections with antiangiogenic factors. We followed the patients over a 12-month period and we evaluated the oxidative stress markers such as superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), glutathione peroxidase (GPx), before and after treatment. By comparing the mean values of SOD, TBARS in the two groups, we found that they were significantly higher in the study group compared to the control group, being higher in patients with severe disease. These values decreased after treatment, but they have remained higher than in controls. This research supports the role of oxidative stress in AMD. This paper opens the perspectives of possible elucidations of the AMD pathogenesis dilemma and supports the need to monitor the evolution by assessing the oxidative stress markers.

Keywords:
age related macular degeneration; oxidative stress; superoxide dismutase; thiobarbituric acid reactive substances; glutathione peroxidase

Issue: 2019, Volume 70, Issue 2

Pages: 483-486

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6939

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IORGA, R.E., DANULESCU, R.S.M., OZTURK, M., COSTIN, D., Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration, Rev. Chim., 70(2), 2019, 483-486.

Vancouver
Iorga RE, Danulescu RSM, Ozturk M, Costin D. Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration. Rev. Chim.[internet]. 2019 Feb;70(2):483-486. Available from: https://doi.org/10.37358/RC.19.2.6939

APA 6th edition
Iorga, R.E., Danulescu, R.S.M., Ozturk, M. & Costin, D. (2019). Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration. Revista de Chimie, 70(2), 483-486. https://doi.org/10.37358/RC.19.2.6939

Harvard
Iorga, R.E., Danulescu, R.S.M., Ozturk, M., Costin, D. (2019). 'Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration', Revista de Chimie, 70(2), pp. 483-486. https://doi.org/10.37358/RC.19.2.6939

IEEE
R.E. Iorga, R.S.M. Danulescu, M. Ozturk, D. Costin, "Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration". Revista de Chimie, vol. 70, no. 2, pp. 483-486, 2019. [online]. https://doi.org/10.37358/RC.19.2.6939

Text
Raluca Eugenia Iorga, Razvana Sorina Munteanu Danulescu, Manuela Ozturk, Danut Costin,
Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 483-486,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6939.
(https://revistadechimie.ro/Articles.asp?ID=6939)
Keywords: age related macular degeneration; oxidative stress; superoxide dismutase; thiobarbituric acid reactive substances; glutathione peroxidase

RIS
TY - JOUR
T1 - Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration
A1 - Iorga, Raluca Eugenia
A2 - Danulescu, Razvana Sorina Munteanu
A3 - Ozturk, Manuela
A4 - Costin, Danut
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 483
EP - 486
UR - https://doi.org/10.37358/RC.19.2.6939
KW - age related macular degeneration
KW - oxidative stress
KW - superoxide dismutase
KW - thiobarbituric acid reactive substances
KW - glutathione peroxidase
ER -

BibTex
@article{RevCh2019P483,
author = {Iorga Raluca Eugenia and Danulescu Razvana Sorina Munteanu and Ozturk Manuela and Costin Danut},
title = {Use of Oxidative Stress Markers in Diagnosis and Evolution of Age-Related Macular Degeneration},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {483-486},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6939},
url = {https://revistadechimie.ro/Articles.asp?ID=6939}
}

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