Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)

Parepa, Irinel Raluca; Stoian, Anca Pantea; Radulescu, Anca Mihaela; Tica, Irina; Mazilu, Laura; Stanculeanu, Dana Lucia; Suceveanu, Adrian Paul; Serafinceanu, Cristian; Suceveanu, Andra-Iulia

Irinel Raluca Parepa, Anca Pantea Stoian, Anca Mihaela Radulescu, Irina Tica, Laura Mazilu, Dana Lucia Stanculeanu, Adrian Paul Suceveanu, Cristian Serafinceanu, Andra-Iulia Suceveanu

Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)

Abstract:

Adiponectin is secreted by fatty tissue; it has a peptide biochemical structure and among other roles, it seems to inhibit endothelial inflammation. C-reactive protein has an essential role in host defense. Troponin is a protein that is part of cardiac and skeletal muscle contraction. Myocardial infarction is an acute event defined as myocardial cell necrosis, caused by sudden and sustained ischemia. The purpose of our search work was to analyze the connection between various biomarkers over the early phase of acute STEMI: adiponectin, high sensitive-C reactive protein (hs-CRP), high sensitive-Troponin T (hs-Troponin T), triglycerides, total -, LDL- and HDL-cholesterol. Our study included two groups of patients - one group of 30 patients diagnosed with STEMI in the first 12 h after onset, and the second group of 30 patients with unstable angina pectoris, normal hs-Troponin T, and normal findings at coronary angiography computed tomography (CT). Subjects in the STEMI-arm had a higher serum level of hs-CRP, hs-Troponin T, total cholesterol, LDL cholesterol, triglycerides, and decreased levels of HDL-cholesterol and adiponectin than those in the angina-arm. We identified diminished adiponectin plasma concentrations during the first hours of STEMI evolution. We also found out a directly proportional ratio among adiponectin and HDL-cholesterol and an inverse report between this hormone and all other studied biomarkers. Our results may support the anti-inflammatory and anti-atherogenic features of adiponectin.

Keywords:
adiponectin; hs-CRP; hs-Troponin T; STEMI

Issue: 2019, Volume 70, Issue 2

Pages: 522-526

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6948

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PAREPA, I.R., STOIAN, A.P., RADULESCU, A.M., TICA, I., MAZILU, L., STANCULEANU, D.L., SUCEVEANU, A.P., SERAFINCEANU, C., SUCEVEANU, A., Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI), Rev. Chim., 70(2), 2019, 522-526.

Vancouver
Parepa IR, Stoian AP, Radulescu AM, Tica I, Mazilu L, Stanculeanu DL, Suceveanu AP, Serafinceanu C, Suceveanu A. Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI). Rev. Chim.[internet]. 2019 Feb;70(2):522-526. Available from: https://doi.org/10.37358/RC.19.2.6948

APA 6th edition
Parepa, I.R., Stoian, A.P., Radulescu, A.M., Tica, I., Mazilu, L., Stanculeanu, D.L.,... Suceveanu, A. (2019). Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI). Revista de Chimie, 70(2), 522-526. https://doi.org/10.37358/RC.19.2.6948

Harvard
Parepa, I.R., Stoian, A.P., Radulescu, A.M., Tica, I., Mazilu, L., Stanculeanu, D.L., Suceveanu, A.P., Serafinceanu, C., Suceveanu, A. (2019). 'Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)', Revista de Chimie, 70(2), pp. 522-526. https://doi.org/10.37358/RC.19.2.6948

IEEE
I.R. Parepa, A.P. Stoian, A.M. Radulescu, I. Tica, L. Mazilu, D.L. Stanculeanu, A.P. Suceveanu, C. Serafinceanu, A. Suceveanu, "Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)". Revista de Chimie, vol. 70, no. 2, pp. 522-526, 2019. [online]. https://doi.org/10.37358/RC.19.2.6948

Text
Irinel Raluca Parepa, Anca Pantea Stoian, Anca Mihaela Radulescu, Irina Tica, Laura Mazilu, Dana Lucia Stanculeanu, Adrian Paul Suceveanu, Cristian Serafinceanu, Andra-Iulia Suceveanu,
Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI),
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 522-526,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6948.
(https://revistadechimie.ro/Articles.asp?ID=6948)
Keywords: adiponectin; hs-CRP; hs-Troponin T; STEMI

RIS
TY - JOUR
T1 - Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)
A1 - Parepa, Irinel Raluca
A2 - Stoian, Anca Pantea
A3 - Radulescu, Anca Mihaela
A4 - Tica, Irina
A5 - Mazilu, Laura
A6 - Stanculeanu, Dana Lucia
A7 - Suceveanu, Adrian Paul
A8 - Serafinceanu, Cristian
A9 - Suceveanu, Andra-Iulia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 522
EP - 526
UR - https://doi.org/10.37358/RC.19.2.6948
KW - adiponectin
KW - hs-CRP
KW - hs-Troponin T
KW - STEMI
ER -

BibTex
@article{RevCh2019P522,
author = {Parepa Irinel Raluca and Stoian Anca Pantea and Radulescu Anca Mihaela and Tica Irina and Mazilu Laura and Stanculeanu Dana Lucia and Suceveanu Adrian Paul and Serafinceanu Cristian and Suceveanu Andra-Iulia},
title = {Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {522-526},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6948},
url = {https://revistadechimie.ro/Articles.asp?ID=6948}
}

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