Aldolase - From Biochemistry to Laboratory Medicine

Creanga, Iulian; Totan, Alexandra; Lupescu, Olivera; Stanescu, Iulia-Ioana; Dumitru, Costin; Greabu, Maria

Iulian Creanga, Alexandra Totan, Olivera Lupescu, Iulia-Ioana Stanescu, Costin Dumitru, Maria Greabu

Aldolase - From Biochemistry to Laboratory Medicine

Abstract:

Aldolase (ALD) (fructose-1,6-bisphosphate aldolase ) is a 160 kDa, enzyme which catalyzes the conversion of fructose 1-6-biphosphate in glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic metabolic pathway. There are also experimental data suggesting that nuclear ALD isoenzyme A might play an important role in cell proliferation. At the present time, the most useful serum markers of muscle injury following intense, prolonged exercise are: creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase myoglobin and troponin. Although serum ALD is not usually measured yet, it may be used together with CK to evaluate the status of muscle adaptation to training. Recent studies offered ALD a new perspective, as a future valuable biomarker in monitoring the evolution of muscle crush injuries, in order to prevent silent, but progressiv muscle fibers necrosis after injury. It has also been shown that ALD was an independent clinical prognostic marker in many other human cancers, being involved in some well-known signaling pathways.

Keywords:
aldolase; crush syndrome; muscle injuries

Issue: 2019, Volume 70, Issue 2

Pages: 578-580

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6959

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CREANGA, I., TOTAN, A., LUPESCU, O., STANESCU, I., DUMITRU, C., GREABU, M., Aldolase - From Biochemistry to Laboratory Medicine, Rev. Chim., 70(2), 2019, 578-580.

Vancouver
Creanga I, Totan A, Lupescu O, Stanescu I, Dumitru C, Greabu M. Aldolase - From Biochemistry to Laboratory Medicine. Rev. Chim.[internet]. 2019 Feb;70(2):578-580. Available from: https://doi.org/10.37358/RC.19.2.6959

APA 6th edition
Creanga, I., Totan, A., Lupescu, O., Stanescu, I., Dumitru, C. & Greabu, M. (2019). Aldolase - From Biochemistry to Laboratory Medicine. Revista de Chimie, 70(2), 578-580. https://doi.org/10.37358/RC.19.2.6959

Harvard
Creanga, I., Totan, A., Lupescu, O., Stanescu, I., Dumitru, C., Greabu, M. (2019). 'Aldolase - From Biochemistry to Laboratory Medicine', Revista de Chimie, 70(2), pp. 578-580. https://doi.org/10.37358/RC.19.2.6959

IEEE
I. Creanga, A. Totan, O. Lupescu, I. Stanescu, C. Dumitru, M. Greabu, "Aldolase - From Biochemistry to Laboratory Medicine". Revista de Chimie, vol. 70, no. 2, pp. 578-580, 2019. [online]. https://doi.org/10.37358/RC.19.2.6959

Text
Iulian Creanga, Alexandra Totan, Olivera Lupescu, Iulia-Ioana Stanescu, Costin Dumitru, Maria Greabu,
Aldolase - From Biochemistry to Laboratory Medicine,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 578-580,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6959.
(https://revistadechimie.ro/Articles.asp?ID=6959)
Keywords: aldolase; crush syndrome; muscle injuries

RIS
TY - JOUR
T1 - Aldolase - From Biochemistry to Laboratory Medicine
A1 - Creanga, Iulian
A2 - Totan, Alexandra
A3 - Lupescu, Olivera
A4 - Stanescu, Iulia-Ioana
A5 - Dumitru, Costin
A6 - Greabu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 578
EP - 580
UR - https://doi.org/10.37358/RC.19.2.6959
KW - aldolase
KW - crush syndrome
KW - muscle injuries
ER -

BibTex
@article{RevCh2019P578,
author = {Creanga Iulian and Totan Alexandra and Lupescu Olivera and Stanescu Iulia-Ioana and Dumitru Costin and Greabu Maria},
title = {Aldolase - From Biochemistry to Laboratory Medicine},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {578-580},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6959},
url = {https://revistadechimie.ro/Articles.asp?ID=6959}
}

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