Effects of Berberis vulgaris  Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia

Neag, Maria Adriana; Bocsan, Ioana Corina; Catinean, Adrian; Vesa, Stefan Cristian; Balan, Gheorghe G.; Parvu, Marcel; Muntean, Dana Maria; Vlase, Laurian; Melincovici, Carmen Stanca; Pop, Raluca; Buzoianu, Anca Dana

Maria Adriana Neag, Ioana Corina Bocsan, Adrian Catinean, Stefan Cristian Vesa, Gheorghe G. Balan, Marcel Parvu, Dana Maria Muntean, Laurian Vlase, Carmen Stanca Melincovici, Raluca Pop, Anca Dana Buzoianu

Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia

Abstract:

The ability of Berberis vulgaris bark extract (BVE) to improve the lipid profile was evaluated in an experimental model of dyslipidemia, along with its effects on liver and kidney functions. Fifty rats divided into five groups of ten animals each were fed with normal or lard-based diet and orally treated with 0.9% saline solution, atorvastatin (2.5 mg/kg per body weight) or extract of BVE (300 and 500 mg/kg/day) for eight weeks. Lipid profile, liver and renal functions were assessed in normal and diet-induced hypercholesterolemic rats. The results were compared between the groups treated with Berberis extract and the group without treatment, respectively that one treated with the standard drug (atorvastatin). Administration of BVE or atorvastatin significantly decreases the elevated serum lipid profile (p [0.05). The extract also protects against dyslipidemia-induced non-alcoholic fatty liver disease (NAFLD). The activities of the plant extract are dose dependent and it compares favorably with the standard drug atorvastatin. Variations in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and urea level measurements were neither different between the two determinations nor between groups, but creatinine values decreased in rats in the BVE or atorvastatin-treated groups. The findings of the current study have suggested that BVE intake suppresses the accumulation of hepatic lipids and lipid parameters and reduce the risk of NAFLD. So, BVE can be useful in hypercholesterolemia.

Keywords:
non-alcoholic fatty liver disease; extract; statins; transaminases; hypercholesterolemia

Issue: 2019, Volume 70, Issue 2

Pages: 614-618

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6968

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NEAG, M.A., BOCSAN, I.C., CATINEAN, A., VESA, S.C., BALAN, G.G., PARVU, M., MUNTEAN, D.M., VLASE, L., MELINCOVICI, C.S., POP, R., BUZOIANU, A.D., Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia, Rev. Chim., 70(2), 2019, 614-618.

Vancouver
Neag MA, Bocsan IC, Catinean A, Vesa SC, Balan GG, Parvu M, Muntean DM, Vlase L, Melincovici CS, Pop R, Buzoianu AD. Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia. Rev. Chim.[internet]. 2019 Feb;70(2):614-618. Available from: https://doi.org/10.37358/RC.19.2.6968

APA 6th edition
Neag, M.A., Bocsan, I.C., Catinean, A., Vesa, S.C., Balan, G.G., Parvu, M.,... Buzoianu, A.D. (2019). Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia. Revista de Chimie, 70(2), 614-618. https://doi.org/10.37358/RC.19.2.6968

Harvard
Neag, M.A., Bocsan, I.C., Catinean, A., Vesa, S.C., Balan, G.G., Parvu, M., Muntean, D.M., Vlase, L., Melincovici, C.S., Pop, R., Buzoianu, A.D. (2019). 'Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia', Revista de Chimie, 70(2), pp. 614-618. https://doi.org/10.37358/RC.19.2.6968

IEEE
M.A. Neag, I.C. Bocsan, A. Catinean, S.C. Vesa, G.G. Balan, M. Parvu, D.M. Muntean, L. Vlase, C.S. Melincovici, R. Pop, A.D. Buzoianu, "Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia". Revista de Chimie, vol. 70, no. 2, pp. 614-618, 2019. [online]. https://doi.org/10.37358/RC.19.2.6968

Text
Maria Adriana Neag, Ioana Corina Bocsan, Adrian Catinean, Stefan Cristian Vesa, Gheorghe G. Balan, Marcel Parvu, Dana Maria Muntean, Laurian Vlase, Carmen Stanca Melincovici, Raluca Pop, Anca Dana Buzoianu,
Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 614-618,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6968.
(https://revistadechimie.ro/Articles.asp?ID=6968)
Keywords: non-alcoholic fatty liver disease; extract; statins; transaminases; hypercholesterolemia

RIS
TY - JOUR
T1 - Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia
A1 - Neag, Maria Adriana
A2 - Bocsan, Ioana Corina
A3 - Catinean, Adrian
A4 - Vesa, Stefan Cristian
A5 - Balan, Gheorghe G.
A6 - Parvu, Marcel
A7 - Muntean, Dana Maria
A8 - Vlase, Laurian
A9 - Melincovici, Carmen Stanca
A10 - Pop, Raluca
A11 - Buzoianu, Anca Dana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 614
EP - 618
UR - https://doi.org/10.37358/RC.19.2.6968
KW - non-alcoholic fatty liver disease
KW - extract
KW - statins
KW - transaminases
KW - hypercholesterolemia
ER -

BibTex
@article{RevCh2019P614,
author = {Neag Maria Adriana and Bocsan Ioana Corina and Catinean Adrian and Vesa Stefan Cristian and Balan Gheorghe G. and Parvu Marcel and Muntean Dana Maria and Vlase Laurian and Melincovici Carmen Stanca and Pop Raluca and Buzoianu Anca Dana},
title = {Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {614-618},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6968},
url = {https://revistadechimie.ro/Articles.asp?ID=6968}
}

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