In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue

Balean, Octavia Iulia; Galuscan, Atena; Jumanca, Daniela; Farcas, Claudia; Coricovac, Dorina; Chioran, Doina; Lazureanu, Voichita; Podariu, Angela Codruta

Octavia Iulia Balean, Atena Galuscan, Daniela Jumanca, Claudia Farcas, Dorina Coricovac, Doina Chioran, Voichita Lazureanu, Angela Codruta Podariu

In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue

Abstract:

The purpose of this in vitro study was to evaluate the efficacy of three different types of bisphosphonates: Actonel (risedronate sodium), Fosamax (alendronic acid) and Ossica (ibandronic acid) on a squamous carcinoma cell line (SCC-4) with tongue tissue origin. The cell viability was assessed after a stimulation period of 24h and the Alamar Blue test was performed. The assessment revealed that the viability of squamous cell carcinoma was slightly reduced after treatment with the smallest concentration of bisphosphonates, with a lowest rate (89%) recorded for Actonel. When a concentration of 2 and 2.5 mM was used, the cell viability was between 85-89% independently of the type of bisphosphonates used. The higher concentrations of 3 mM, 4 mM showed a significant reduction of 72% when using Fosamax, and 68% when using Ossica. We can state that the viability of tongue squamous cell carcinoma cells decreases as the concentration of bisphosphonates used increases.

Keywords:
bisphosphonates; tongue squamous cell carcinoma; cell viability

Issue: 2019, Volume 70, Issue 2

Pages: 663-666

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6980

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BALEAN, O.I., GALUSCAN, A., JUMANCA, D., FARCAS, C., CORICOVAC, D., CHIORAN, D., LAZUREANU, V., PODARIU, A.C., In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue, Rev. Chim., 70(2), 2019, 663-666.

Vancouver
Balean OI, Galuscan A, Jumanca D, Farcas C, Coricovac D, Chioran D, Lazureanu V, Podariu AC. In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue. Rev. Chim.[internet]. 2019 Feb;70(2):663-666. Available from: https://doi.org/10.37358/RC.19.2.6980

APA 6th edition
Balean, O.I., Galuscan, A., Jumanca, D., Farcas, C., Coricovac, D., Chioran, D., Lazureanu, V. & Podariu, A.C. (2019). In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue. Revista de Chimie, 70(2), 663-666. https://doi.org/10.37358/RC.19.2.6980

Harvard
Balean, O.I., Galuscan, A., Jumanca, D., Farcas, C., Coricovac, D., Chioran, D., Lazureanu, V., Podariu, A.C. (2019). 'In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue', Revista de Chimie, 70(2), pp. 663-666. https://doi.org/10.37358/RC.19.2.6980

IEEE
O.I. Balean, A. Galuscan, D. Jumanca, C. Farcas, D. Coricovac, D. Chioran, V. Lazureanu, A.C. Podariu, "In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue". Revista de Chimie, vol. 70, no. 2, pp. 663-666, 2019. [online]. https://doi.org/10.37358/RC.19.2.6980

Text
Octavia Iulia Balean, Atena Galuscan, Daniela Jumanca, Claudia Farcas, Dorina Coricovac, Doina Chioran, Voichita Lazureanu, Angela Codruta Podariu,
In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 663-666,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6980.
(https://revistadechimie.ro/Articles.asp?ID=6980)
Keywords: bisphosphonates; tongue squamous cell carcinoma; cell viability

RIS
TY - JOUR
T1 - In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue
A1 - Balean, Octavia Iulia
A2 - Galuscan, Atena
A3 - Jumanca, Daniela
A4 - Farcas, Claudia
A5 - Coricovac, Dorina
A6 - Chioran, Doina
A7 - Lazureanu, Voichita
A8 - Podariu, Angela Codruta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 663
EP - 666
UR - https://doi.org/10.37358/RC.19.2.6980
KW - bisphosphonates
KW - tongue squamous cell carcinoma
KW - cell viability
ER -

BibTex
@article{RevCh2019P663,
author = {Balean Octavia Iulia and Galuscan Atena and Jumanca Daniela and Farcas Claudia and Coricovac Dorina and Chioran Doina and Lazureanu Voichita and Podariu Angela Codruta},
title = {In vitro Effect of Bisphosphonates on Squamous Cell Carcinoma from Tongue Tissue},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {663-666},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6980},
url = {https://revistadechimie.ro/Articles.asp?ID=6980}
}

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