Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia

Singer, Cristina Elena; Dinescu, Sorin Nicolae; Tudorascu, Diana Rodica; Florescu, Cristina; Dinescu, Venera Cristina; Puiu, Ileana; Calborean, Veronica; Trasca, Diana-Maria

Cristina Elena Singer, Sorin Nicolae Dinescu, Diana Rodica Tudorascu, Cristina Florescu, Venera Cristina Dinescu, Ileana Puiu, Veronica Calborean, Diana-Maria Trasca

Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia

Abstract:

Acute lymphoblastic leukemia (ALL) is the most frequent malign hematologic disease in children. We studied the hematologic toxicity caused by the cytostatic treatment which was administered to the children diagnosed with ALL, according to the ALL-IC-BFM 2002/2009 protocol. The study included a number of 15 children with ALL who were treated from 2008 to 2018 within the Oncopediatrics Department of the 2nd Pediatric Clinic of the Emergency County Hospital in Craiova. We decided upon the level of toxicity in blood values, taking into account the severity level (G), according to the Common Terminology Criteria for Adverse Events 2010 guideline and we calculated the mean value of the hemoglobin, leukocytes, neutrophils, and thrombocytes in the children with ALL, for every phase of the cytostatic treatment. The most severe toxicity (grade 4 of severity) was registered in neutrophils (7/15 patients), during the induction and re-induction periods; 4 of these patients had severe infections.

Keywords:
hematological toxicity; polichemotherapy protocols; acute lymphoblastic leukemia; children

Issue: 2019, Volume 70, Issue 5

Pages: 1671-1675

Publication date: 2019/6/15

https://doi.org/10.37358/RC.19.5.7190

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SINGER, C.E., DINESCU, S.N., TUDORASCU, D.R., FLORESCU, C., DINESCU, V.C., PUIU, I., CALBOREAN, V., TRASCA, D., Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia, Rev. Chim., 70(5), 2019, 1671-1675.

Vancouver
Singer CE, Dinescu SN, Tudorascu DR, Florescu C, Dinescu VC, Puiu I, Calborean V, Trasca D. Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia. Rev. Chim.[internet]. 2019 May;70(5):1671-1675. Available from: https://doi.org/10.37358/RC.19.5.7190

APA 6th edition
Singer, C.E., Dinescu, S.N., Tudorascu, D.R., Florescu, C., Dinescu, V.C., Puiu, I., Calborean, V. & Trasca, D. (2019). Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia. Revista de Chimie, 70(5), 1671-1675. https://doi.org/10.37358/RC.19.5.7190

Harvard
Singer, C.E., Dinescu, S.N., Tudorascu, D.R., Florescu, C., Dinescu, V.C., Puiu, I., Calborean, V., Trasca, D. (2019). 'Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia', Revista de Chimie, 70(5), pp. 1671-1675. https://doi.org/10.37358/RC.19.5.7190

IEEE
C.E. Singer, S.N. Dinescu, D.R. Tudorascu, C. Florescu, V.C. Dinescu, I. Puiu, V. Calborean, D. Trasca, "Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia". Revista de Chimie, vol. 70, no. 5, pp. 1671-1675, 2019. [online]. https://doi.org/10.37358/RC.19.5.7190

Text
Cristina Elena Singer, Sorin Nicolae Dinescu, Diana Rodica Tudorascu, Cristina Florescu, Venera Cristina Dinescu, Ileana Puiu, Veronica Calborean, Diana-Maria Trasca,
Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia,
Revista de Chimie,
Volume 70, Issue 5,
2019,
Pages 1671-1675,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.5.7190.
(https://revistadechimie.ro/Articles.asp?ID=7190)
Keywords: hematological toxicity; polichemotherapy protocols; acute lymphoblastic leukemia; children

RIS
TY - JOUR
T1 - Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia
A1 - Singer, Cristina Elena
A2 - Dinescu, Sorin Nicolae
A3 - Tudorascu, Diana Rodica
A4 - Florescu, Cristina
A5 - Dinescu, Venera Cristina
A6 - Puiu, Ileana
A7 - Calborean, Veronica
A8 - Trasca, Diana-Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 5
SP - 1671
EP - 1675
UR - https://doi.org/10.37358/RC.19.5.7190
KW - hematological toxicity
KW - polichemotherapy protocols
KW - acute lymphoblastic leukemia
KW - children
ER -

BibTex
@article{RevCh2019P1671,
author = {Singer Cristina Elena and Dinescu Sorin Nicolae and Tudorascu Diana Rodica and Florescu Cristina and Dinescu Venera Cristina and Puiu Ileana and Calborean Veronica and Trasca Diana-Maria},
title = {Considerations on the Hematologic Toxicity of the all IC-BFM 2002/2009 Therapeutic Protocol in Children with Acute Lymphoblastic Leukemia},
journal = {Revista de Chimie},
volume = {70},
number = {5},
pages = {1671-1675},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.5.7190},
url = {https://revistadechimie.ro/Articles.asp?ID=7190}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)

News, Events

Gold Open Access | Source=http://www.plos.org/ | Author=art designer at PLoS

Conferences of Contemporary
Chemistry

Biblioteca Chimiei

Materiale Plastice

REVISTA DE CHIMIE

About

Board

Indexing