Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

Trambitas, Cristian; Pop, Anca Maria; Miron, Alina Dia Trambitas; Dorobantu, Dorin Constantin; Tabaran, Flaviu; Cordos, Bogdan; Suciu, Bogdan Andrei; Brinzaniuc, Klara

Cristian Trambitas, Anca Maria Pop, Alina Dia Trambitas Miron, Dorin Constantin Dorobantu, Flaviu Tabaran, Bogdan Cordos, Bogdan Andrei Suciu, Klara Brinzaniuc

Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

Abstract:

Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We used 16 male Wistar rats subjected to a specific protocol based on which 2 calvarial bone defects were created in each animal, one was filled with Bon Alive S53P4 bioactive glass and adipose-derived stem cells and the other one was considered control. At intervals of one week during the following month, the animals were euthanized and the specimens from bone defects were histologically examined and compared. The results showed that this biomaterial was biocompatible and the first signs of osseous healing appeared in the third week. Bone Alive S53P4 bioactive glass could be an excellent bone substitute, reducing the need of bone grafts.

Keywords:
bioactive glass; regeneration of bone defects; adipose-derived stem cells; osteogenic differentiation

Issue: 2019, Volume 70, Issue 6

Pages: 1983-1987

Publication date: 2019/7/15

https://doi.org/10.37358/RC.19.6.7259

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TRAMBITAS, C., POP, A.M., MIRON, A.D.T., DOROBANTU, D.C., TABARAN, F., CORDOS, B., SUCIU, B.A., BRINZANIUC, K., Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study, Rev. Chim., 70(6), 2019, 1983-1987.

Vancouver
Trambitas C, Pop AM, Miron ADT, Dorobantu DC, Tabaran F, Cordos B, Suciu BA, Brinzaniuc K. Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study. Rev. Chim.[internet]. 2019 Jun;70(6):1983-1987. Available from: https://doi.org/10.37358/RC.19.6.7259

APA 6th edition
Trambitas, C., Pop, A.M., Miron, A.D.T., Dorobantu, D.C., Tabaran, F., Cordos, B., Suciu, B.A. & Brinzaniuc, K. (2019). Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study. Revista de Chimie, 70(6), 1983-1987. https://doi.org/10.37358/RC.19.6.7259

Harvard
Trambitas, C., Pop, A.M., Miron, A.D.T., Dorobantu, D.C., Tabaran, F., Cordos, B., Suciu, B.A., Brinzaniuc, K. (2019). 'Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study', Revista de Chimie, 70(6), pp. 1983-1987. https://doi.org/10.37358/RC.19.6.7259

IEEE
C. Trambitas, A.M. Pop, A.D.T. Miron, D.C. Dorobantu, F. Tabaran, B. Cordos, B.A. Suciu, K. Brinzaniuc, "Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study". Revista de Chimie, vol. 70, no. 6, pp. 1983-1987, 2019. [online]. https://doi.org/10.37358/RC.19.6.7259

Text
Cristian Trambitas, Anca Maria Pop, Alina Dia Trambitas Miron, Dorin Constantin Dorobantu, Flaviu Tabaran, Bogdan Cordos, Bogdan Andrei Suciu, Klara Brinzaniuc,
Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study,
Revista de Chimie,
Volume 70, Issue 6,
2019,
Pages 1983-1987,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.6.7259.
(https://revistadechimie.ro/Articles.asp?ID=7259)
Keywords: bioactive glass; regeneration of bone defects; adipose-derived stem cells; osteogenic differentiation

RIS
TY - JOUR
T1 - Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study
A1 - Trambitas, Cristian
A2 - Pop, Anca Maria
A3 - Miron, Alina Dia Trambitas
A4 - Dorobantu, Dorin Constantin
A5 - Tabaran, Flaviu
A6 - Cordos, Bogdan
A7 - Suciu, Bogdan Andrei
A8 - Brinzaniuc, Klara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 6
SP - 1983
EP - 1987
UR - https://doi.org/10.37358/RC.19.6.7259
KW - bioactive glass
KW - regeneration of bone defects
KW - adipose-derived stem cells
KW - osteogenic differentiation
ER -

BibTex
@article{RevCh2019P1983,
author = {Trambitas Cristian and Pop Anca Maria and Miron Alina Dia Trambitas and Dorobantu Dorin Constantin and Tabaran Flaviu and Cordos Bogdan and Suciu Bogdan Andrei and Brinzaniuc Klara},
title = {Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study},
journal = {Revista de Chimie},
volume = {70},
number = {6},
pages = {1983-1987},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.6.7259},
url = {https://revistadechimie.ro/Articles.asp?ID=7259}
}

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