New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity

Araniciu, Catalin; Oniga, Smaranda Dafina; Benedec, Daniela; Crisan, Ovidiu; Vlase, Laurian; Palage, Mariana; Oniga, Ovidiu

Catalin Araniciu, Smaranda Dafina Oniga, Daniela Benedec, Ovidiu Crisan, Laurian Vlase, Mariana Palage, Ovidiu Oniga

New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity

Abstract:

In an effort to obtain new NSAIDs, that act as COX-2 selective inhibitors with simultaneous iNOS inhibition properties and direct antioxidant activity, we designed a series of 8 new compounds bearing the 5-thiazolyl-carbohydrazon-N-allyl-thiazoline scaffold. The synthesized compounds were physicochemically characterized by: 1H-NMR, MS and elemental analysis. An initial, in vitro, free radical scavenging assay (DPPH bleaching) test showed that most compounds are superior to standard antioxidants Trolox and BHT.

Keywords:
thiazole; antioxidant; NSAIDs; iNOS; DPPH

Issue: 2019, Volume 70, Issue 7

Pages: 2340-2343

Publication date: 2019/8/15

https://doi.org/10.37358/RC.19.7.7335

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ARANICIU, C., ONIGA, S.D., BENEDEC, D., CRISAN, O., VLASE, L., PALAGE, M., ONIGA, O., New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity, Rev. Chim., 70(7), 2019, 2340-2343.

Vancouver
Araniciu C, Oniga SD, Benedec D, Crisan O, Vlase L, Palage M, Oniga O. New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity. Rev. Chim.[internet]. 2019 Jul;70(7):2340-2343. Available from: https://doi.org/10.37358/RC.19.7.7335

APA 6th edition
Araniciu, C., Oniga, S.D., Benedec, D., Crisan, O., Vlase, L., Palage, M. & Oniga, O. (2019). New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity. Revista de Chimie, 70(7), 2340-2343. https://doi.org/10.37358/RC.19.7.7335

Harvard
Araniciu, C., Oniga, S.D., Benedec, D., Crisan, O., Vlase, L., Palage, M., Oniga, O. (2019). 'New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity', Revista de Chimie, 70(7), pp. 2340-2343. https://doi.org/10.37358/RC.19.7.7335

IEEE
C. Araniciu, S.D. Oniga, D. Benedec, O. Crisan, L. Vlase, M. Palage, O. Oniga, "New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity". Revista de Chimie, vol. 70, no. 7, pp. 2340-2343, 2019. [online]. https://doi.org/10.37358/RC.19.7.7335

Text
Catalin Araniciu, Smaranda Dafina Oniga, Daniela Benedec, Ovidiu Crisan, Laurian Vlase, Mariana Palage, Ovidiu Oniga,
New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2340-2343,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7335.
(https://revistadechimie.ro/Articles.asp?ID=7335)
Keywords: thiazole; antioxidant; NSAIDs; iNOS; DPPH

RIS
TY - JOUR
T1 - New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity
A1 - Araniciu, Catalin
A2 - Oniga, Smaranda Dafina
A3 - Benedec, Daniela
A4 - Crisan, Ovidiu
A5 - Vlase, Laurian
A6 - Palage, Mariana
A7 - Oniga, Ovidiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2340
EP - 2343
UR - https://doi.org/10.37358/RC.19.7.7335
KW - thiazole
KW - antioxidant
KW - NSAIDs
KW - iNOS
KW - DPPH
ER -

BibTex
@article{RevCh2019P2340,
author = {Araniciu Catalin and Oniga Smaranda Dafina and Benedec Daniela and Crisan Ovidiu and Vlase Laurian and Palage Mariana and Oniga Ovidiu},
title = {New 5-Thiazolyl-carbohydrazon-n-allyl-thiazolines Synthesis, characterization and antioxidant activity},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2340-2343},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7335},
url = {https://revistadechimie.ro/Articles.asp?ID=7335}
}

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